支气管哮喘

The simultaneity use of Xiao Er Chuan Ke Ye and Cang Er Zi San intervening asthma and allergic rhinitis,comparing simply use Xiao Er Chuan Ke Ye,has the predominance in prolonging time of introducing asthma and reducing the frequency of nodding breathe,which indicated that the treatment of allergic rhinitis has great importance in asthma control and lessen the degree of asthma(frequency of rat nodding breath).3,The combination high-dose group has better therapeutic effect than dexamethasone group,all Chuan Ke Ye groups and combination low,medium group in the prevention and control of allergic rhinitis symptoms,reduced airway hyper responsiveness,while in improving breath difficulties combination high-dose group has similar effect with western medicine group,and better effect than all Chuan Ke Ye groups and combination low,medium group.Its efficacy increased with the prolonging of treatment time,but fewer side effects,which makes the application safer and more reliable.4,Xiao Er Chuan Ke Ye combining with Cang Er Zi San can obviously improve the pathological changes in rats with bronchial airway remodeling,reducing the serum TGF-β1,IL-4,ECP levels,increasing the level of serum IFN-γand the imbalance IFN-γ/ IL-4 ratio.

而运用小儿喘咳液合苍耳子散同时干预哮喘与过敏性鼻炎，较之单纯使用小儿喘咳液治疗哮喘，其在延长引喘时间、减少点头呼吸频度等方面有明显的优势，说明过敏性鼻炎的治疗，对于控制哮喘发生，减轻哮喘发作的程度，有着重要的意义。3、大剂量的合方在预防和控制过敏性鼻炎症状、降低哮喘气道高反应性方面疗效较地塞米松对照组、喘咳液各剂量组及合方小、中剂量组更优，而改善呼吸困难方面则与西药组相当，优于喘咳液各剂量组及合方小、中剂量组，且其疗效随着治疗时间的延长而增加，但副作用更少，使用更加安全可靠。4、小儿喘咳液合苍耳子散能明显改善气道重塑大鼠支气管的病理改变，同时降低血清TGF-β1、IL-4、ECP水平，提高血清IFN-γ水平及失衡的IFN-γ/IL-4比值。

Results There was no apparent gender difference among 14 patients. 9 patients were younger than 30 years old. Pathological examination showed that bronchial infiltration of eosinophils in 14 patient (100%), thickened basement membrane of the bronchial mucosa in 12 patients (85.7%), proliferation of smooth muscle cells in 11 patients (78.6%), proliferative mucous gland in 9 patients (64.3%), mucous plug in bronchiole in 8 patients (57.1%), and cicatvization of left ventricle in 10 patients (71.4%).

结果哮喘猝死患者无性别差异，年龄30岁以下者9例(64.3%)；病理改变的特点为支气管管壁嗜酸细胞浸润14例(100%)，粘膜基底膜增厚12例(85.7%)，支气管平滑肌细胞增生11例(78.6%)，粘液腺增生、肥大9例(64.3%)，细支气管内粘液栓形成8例(57.1%)；左心室壁瘢痕形成10例(71.4%)，病变主要位于左心室侧壁和心尖部。

The result showed a thick and dense distribution of bronchus and bronchiole of asthma group; a sparse distribution in respiratory bronchiole and pulmonary alveoli; some positive fibers extrude the epithelium mucosae into the alveoli.

结果发现哮喘组肺内支气管及细支气管阳性纤维增粗、分布密集度显著增加；在呼吸性细支气管及肺泡亦偶有分布；有部分阳性纤维经粘膜上皮内伸出并暴露于管腔内。

Methods 24 SD rats were randomly divided into normal group,model group,aminophylline treatment group(35 mg/kg), 8 rats in each group. The bronchial asthma model in rats was built by egg protein sensibilization and longterm inhalation provocation. The rats in treatment group were lavaged each day from the first time of provocation.After 4week treatment, the rats were killed to obtain lung tissue for staining with HE.

24只SD大鼠随机分为正常组、模型组、治疗组，每组8只，除正常组外以卵蛋白致敏并吸入激发法制备大鼠哮喘模型，治疗组、模型组从第1次哮喘激发开始(造模第3周)分别给予氨茶碱、0.9%氯化钠溶液灌胃给药，1次/d，用药4周处死大鼠，取肺组织HE染色，用彩色图像分析仪测量支气管壁面积、支气管平滑肌面积，用ELISA双抗体夹心法测定肺组织MMP9和TIMP1含量。

BE1 monoclonal antibody can be used to detect basophils in tissue.

BB1单克隆抗体可有效地用于支气管肺组织标本的嗜碱性粒细胞免疫组织化学检测，同时急性发作的致死性哮喘患者气道中嗜碱性粒细胞明显增加，可能与哮喘病情恶化、甚至死亡有关，而非致死性的慢性哮喘患者气道中嗜碱性粒细胞与对照组无异，说明嗜碱性粒细胞可能主要参与哮喘的急性病程。

In this study, We typed the the gene of β〓-AR from genomic DNA of asthmatic patients and made the further analysis: The distributing condition of genetic polymorphisms at positions 16 and 27 in β〓 AR coding region and at position 19 in 5'Leader Cistron (5'LC) among southwest Chinese asthmatic population; The relationship between the each polymorphisms at the above three positions and the asthmatic phenotypes (FEV〓 or nocturnal asthma); The effect of each polymorphisms at the above three positions on bronchodilator responsiveness induced by β〓- agonists(initial bronchodilator response, pharmaco-dynamic); The relationship between the haplotypes of polymorphisms in the 5'LC or in positions 16, 27 of β〓AR coding block and asthmatic phenotypes or bronchodilator responsiveness induced by β〓-agonists.

实验通过对哮喘人群的β〓-AR基因进行分型，探讨：β〓-AR编码区16、27位点及5'前导肽(5'LeaderCistron，5'LC)19位点遗传多态性在中国西南地区哮喘人群中的分布情况；三个位点多态性与哮喘临床表现型的关系；三个位点多态性对β〓受体激动剂反应性(支气管舒张反应，舒张反应动力学)的影响；16、27位点及5'前导肽19位点遗传多态性单倍型与哮喘临床表现型及β〓受体激动剂反应性的关系。

Methods Divides into two groups 77 example bronchial tube asthma,control group convention use aminophylline,dexamethasone;Treatment group in conventional treatment foundation,adds with 26% magnesium sulfate 10 ml+5% glucose inoculation fluid 250 ml static drop,30 drops of minutes, daily one time.

将77例支气管哮喘分为两组，对照组常规使用氨茶碱，地塞米松；治疗组在常规治疗的基础上，加用26%硫酸镁10 ml+5%葡萄糖注射液250 ml静滴，30滴/min，每日一次。

the atomization inhales bolley connie and pu the mick command extends the treatment bronchial tube asthma ute attack safe effective, is worth the clinical promotion.

雾化吸入博利康尼及普米克令舒治疗支气管哮喘急性发作安全有效，值得临床推广。

The choice bronchial tube asthma acute attack patient 64 examples, stochastically divide into the treatment group 32 examples and the comparison group 32 examples; Two groups give the conventional anti- inflammation, the spasmolysis treatment, treatment group Canada add xqljsg decoction to take orally, the observation clinical symptom, the body draft andthe physics and chemistry inspection.

选择支气管哮喘急性发作期患者64例，随机分为治疗组32例、对照组32例；两组均予常规抗炎、解痉治疗，治疗组给予小青龙加石膏汤口服，观察临床症状、体征及理化检查。

Bee venom is a body of a toxic liquid, adrenocorticotropic hormone, helps treat bronchial asthma and other allergic diseases; second, honey contains a certain amount of pollen grains inside, often drink can have a certain immunity to pollen allergies.

蜂毒是蜜蜂体内的一种有毒液体，促肾上腺皮质激素，有助于治疗支气管哮喘等过敏性疾病；二是蜂蜜里面含有一定的花粉粒，经常喝可以对花粉过敏产生一定的免疫力。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。