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Furthermore, in the system, the function of speech cue offers a favorable interface for human-computer interaction.

并且，本系统的语音提示功能为人机交流提供了一个良好界面。

A humdinger of a tale about the animal is often a clue that this is a wine to avoid.

对动物的大肆渲染，往往是提示我们不要买这样的酒。

On the contrary, there were no significant alternation in the levels of PKCδ and PKCε after HupA treatment, indicating no contribution of these two subtypes.

同时还观察到，石杉碱甲对PKC另外两个亚型PKC与PKC的蛋白水平没有明显的影响，提示石杉碱甲增加sAPPα分泌的作用与PKC、PKC没有关联。

In general, we conclude that HupA can regulate the metabolism of APP in addition to improving the cholinergic neurotransmission and protecting neuronal cells against multiple injuries.

综上所述，本论文的研究提示，石杉碱甲除改善胆碱能传递功能、对抗多因素诱发的细胞损伤外，还对β-淀粉样蛋白的代谢过程具有调节作用。

Atropine and Carbacol had no effect on the inhibition of 〓 and 〓 by HupA, indicating that the inhibition was unrelated to the cholinergic signaling pathway.

这提示，HupA可能是作为开放阻断剂，堵塞于K通道的开口，HupA通过影响C-型失活机制而使电流衰减的速度变慢了。

Secretion of sAPPα and expression of PKCα were found to increase after cells were incubated with HupA, suggesting a possible correlation between these two changes.

Western blotting结果显示sAPPα和PKCα蛋白水平均随着与石杉碱甲孵育的时间增加而增高。sAPPα的显著上升出现于PKCα上升之前，提示石杉碱甲对sAPPα分泌的调节可能与提高PKCα表达水平有关。

Meanwhile, HupA produced significant reversal of Aβ-induced deficit in memory and learning assayed by water maze performance, indicating that regulation of APP processing might contribute to the cognitive improving effect of HupA.

水迷宫行为学检测结果显示，皮层和海马中sAPPα分泌的变化与大鼠学习记忆能力呈良好的相关性，提示石杉碱甲对sAPPα的调节可能有利于学习记忆的改善。

HupA reversibly slowed down the decay of 〓, in addition to causing a reduction in its amplitude. So HupA may block the 〓 also as an open channel blocker at the out mouth of the channels.

这提示，HupA可能是作为开放阻断剂，堵塞于K通道的开口，HupA通过影响C-型失活机制而使电流衰减的速度变慢了。

Increases of APP transcript and expression by HupA also contribute to the up-regulation of sAPPα secretion. Meanwhile, Aβ secretion was observed to decrease 2 h after HupA treatment, and after 24 h incubation, HupA can significantly inhibit the secretion of Aβ.

Real-time PCR和Western blotting结果提示石杉碱甲能增加APP的转录和表达，该作用也将有助于对sAPPα分泌的上调；同时Aβ的生成并未相应增加，ELISA检测结果显示石杉碱甲孵育2 h后即能对Aβ分泌产生抑制作用，孵育24 h后能显著降低Aβ水平。

The above results suggests that the hydrolase and FMO in microsomes are involved in the formation of M1 and M2 respectively.

黄素单氧化酶的特异性抑制剂甲巯咪唑可以显著地抑制M2的形成，但对M1的形成无明显的抑制作用，且M1在肝微粒体中的形成为NADPH非依赖性，上述结果提示参与M1和M2代谢的酶分别为肝微粒体中的水解酶和黄素单氧化酶。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失