提示...

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗(来源：A44B8787C论文网www.abclunwen.com)功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

Furthormore, xNorrin can not activate canonical Wnt signaling in the endomesoderm, suggesting additional mechanisms to restrict xNorrin activity in the ectoderm besides of its RNA localization in the animal pole..

进一步的体内实验表明，xNorrin协同xFrizzled4及xLrp5/6只能在外胚层激活经典Wnt信号通路，而在内中胚层中这种活性则很低，提示除了其RNA定位在动物极细胞之外，还存在着另外一种分子机制将xNorrin的活性限制在背部外胚层。

The appearance of increased poikilocytosis, anisocytosis, and RBC inclusions suggests that a spleen is not present.

异形红细胞增多、红细胞大小不等以及红细胞内容物的出现均提示脾已不存在。

My Way - Wikipedia, the free encyclopedia-"My Way" is an English versionof a French song. The English lyrics were written by Paul Anka and popularized by Frank Sinatra on his 1969 album My Way....

2009年8月11日。。。我是个全球卫星导航系统装置的大粉丝，其实我相当依赖它，所以在我的iPhone 3GS里你会同时看到两款最新的有路口转弯提示的GPS导航程式，70美元。。。

The 5 SLE patients, however, displayed anomalous proliferation and oligoclonal expansion of the T cells was observed in different TCR BV families with different CDR3 sequences.

SLE活动期外周血T细胞TCRβ链CDR3谱系出现明显漂移，提示CDR3的选择性表达可能与SLE的免疫发病机理有关。

There was an obvious increase of insulin receptor gene and protein in the cerebral ischemia reperfusion tissues in rats. The positive cells such as neuron, neuroglia cells, vascular endothelium cells possibly participated in regulating the processes of energy metabolism of cells and neovascularization. It implied that the high expressions of insulin receptors in vascular endothelium cells in ischemic zones possibly participated in regulating the pathophysiological changes of the blood vessels in ischemic zones; The higher expressions of insulin receptors in different cells were possibly one of the self-protective machanisms in which the ischemic tissues confront the anoxemia injury.

脑缺血再灌注大鼠脑组织胰岛素受体基因和蛋白水平表达增加；半暗带区神经元、部分神经胶质细胞及血管内皮细胞等阳染细胞可能参与脑缺血后组织细胞的能量代谢、促新生细胞形成等病理生理调节过程；胰岛素受体在缺血区血管内皮细胞高表达提示其可能在缺血区血管的病理生理变化中起某种调节作用；胰岛素受体在不同细胞中表达增高可能是缺血脑组织对抗缺血缺氧损伤的自身保护机制之一。

In the survival group, patients' blood dynamics were stable gradually, DO2 and VO2 increased obviously, the blood lactic acid level was low, after complex therapy the patients were survival, however, in the death group the data demonstrated that patients' blood dynamics were unstable, the DO2 and VO2 was difficult to increase, and the blood lactic acid kept at high level, it showed that the tissues were seriously inthe condition of ischemia and anoxemia, the cell function failure was irreversible, although many kinds of complex therapy were carried on, the patient still died finally.

生存组中，患者血液动力学逐渐平稳，DO2和VO2均明显升高，血乳酸水平较低，经综合治疗后患者得于存活，而死亡组数据显示，患者血液动力学不稳定，DO2和VO2的提高非常困难，且血乳酸水平持续较高，提示组织缺血缺氧严重，细胞功能衰竭不可逆，虽采取多种措施进行综合治疗，但患者最终仍然死亡。

Results There were obvious mandible changes such as the increase of SNB angle and decrease of ANB angle and overjet after treatment with Twinblock, suggestive of mandible growth, increase of facial angle, reduction of mandible process angle, mild adduction of upper incisors, and mild anteversion of lower incisors.

结果 矫治前后下颌骨的变化具有统计学意义，表现在SNB角的增大和ANB角、OJ的减小，提示下颌骨的生长、面角增加和颌突角减小，上前牙轻度内收和下前牙少量前倾。

The results of a phase II study suggest that a new drug candidate is an effective and convenient anticoagulant.

一项II期临床研究的结果提示，一种新型候选药物是有效而便利的抗凝剂。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。