排泄药

In the present study, the new sensitive and specific LC/MS/MS method was developed for the simultaneous determination of magnesium lithospermate B, rosmarinic acid and lithospermic acid and their major metabolites in biological samples. The pharmacokinetics of S. miltiorrhiza depside salts in dogs, rats, and humans conducted the developed LC/MS/MS method, and they would be useful for new drug development and design.

在此基础上，系统研究了创新中药丹参多酚酸盐多个成分在Beagle犬及大鼠体内的药物代谢动力学特征，包括多剂量、多种给药方式的影响，及吸收、分布、代谢、排泄特征；同时进行人体药物代谢动力学研究，为设计合理给药方案和临床安全有效用药提供了理论依据，对传统中药的现代化研究具有显著的示范作用。

Results: For CRF rats which made by fed with feedingstuff contains 0.75% of adenine for 4 weeks, the weight of model control group rats were lighter than that of Yi Shen Granule groups rats. The water wastage of Yi Shen Granule groups rats were less than that of model control group rats. Compared urine volume, the ejectable quantity of Na, K, Cl and proteinuria in 12 hours , the data of Yi Shen Granule groups rats were less than that of model control rats. The specific gravity of Yi Shen Granule groups rats was higher than that of model control rats. The numerical value of RBC, HGB, HCT, MCV, MCH in model control group was lower than that in Yi Shen Granule groups. The content of BUN and Cre in serum of model control groups rats were higher than that of Yi Shen Granule groups. The results of excretion test of phenolsulfonphthalein showed that the RPF of Yi Shen Granule groups rats was larger than that of model control group rats.

结果： 益肾颗粒可以使0.75%腺嘌呤饲喂法致大鼠慢性肾衰模型动物体重增长加快；给药后观察，给药组动物饮水量较少，12小时尿量、12小时钠、氯、尿蛋白排泄总量均显著低于模型组动物，尿液比重值较大；模型组动物的RBC、HGB、HCT、MCV、MCH等指标的数值较给药组动物的数值小；给药组动物血清中BUN和Cre的含量较低；给药组动物酚红排泄率均高于模型组动物；给药30天，处死各组动物，尸解观察，模型对照组动物肾脏呈灰白色，各给药组动物肾脏表面均出现不同程度的红、白相兼的颗粒状纹理，各组动物肾脏均肿大，切面可见不同程度的腺嘌呤结晶沉积。

AIM: To study the pharmacokinetics of astragaloside Ⅳ in rabbits and its excretion in rats.

目的 ：研究黄芪甲苷在家兔体内的药动学和在大鼠的排泄。

Then,the accumulated excretion rate of luteolin and apigenin in the three courses were calculated.

与此同时，在胆汁中两者也有一定的累积排泄量，分别占给药剂量的2.05%和6.34%。

It must be cautiously used for animals with renal dysfunction because of delay of sulfanilamide excretion.

肾功能障碍时，磺胺药排泄延缓，应慎用。

Objective: A HPLC-ECD method was established to determine scutellarin in rat bile.

中文摘要：目的：建立大鼠胆汁中灯盏花乙素的高效液相-电化学色谱测定方法，研究灌胃给药灯盏花乙素苷元200 mg·kg-1后，代谢产物在胆汁中的排泄方式。

In order to investigate the profile of absorption, excretion and retainment of As〓S〓, and to estimate the influence of Semen platycladi and other excipient in As〓S〓 absorption, we studied the pharmacokinetics in humans and mice respectively.

为了了解As〓S〓复方胶囊在人体内吸收、排泄、蓄积等规律，我们进行了临床药代动力学研究，同时，为了比较复方制剂及不同赋形剂对As〓S〓吸收的影响，进行了动物药代动力学实验。

Because elderly patients with a lower basal metabolism, body reserve capacity is poor, and drug metabolism in liver and kidney functions closely related to the poor so that a reduced ability to excrete drugs, high blood concentration, and therefore need to take full advantage of the process of medication dosage, to ensure the safety of the treatment.

由于老年患者基础代谢较低，机体储备能力差，与药物代谢关系密切的肝肾功能不佳，从而使药物排泄能力下降，血药浓度偏高，因此在用药过程中需要充分把握药物的剂量，保证治疗的安全性。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。