损害的

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗(来源：A44B8787C论文网www.abclunwen.com)功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

But while the performance and reliability of Spring certainly doesn't hurt, the primary driving force behind Spring adoption is still the simplified programming model it provides.

但是在Spring的效率和可靠性确定没有损害的同时，推动Spring使用的主要驱动力依然是它提供的简化的编程模型。

It also should take the labor relation between the act agent of direct rights violation and responsibility coverers.

要求造成他人损害的行为是雇员从事雇佣活动的行为或者说是雇员的职务行为，这种职务行为有判断的标准，根据判断来制定雇主的职责。

The worst frost damage occurs in areas that are usually frost-free, where exposed mature tropical trees, such as mango, or indigenous plants, such as tree ferns and eucalypts, can be set back or even killed.

霜冻造成的最大的损害的地区是那些几乎没有霜的，有成熟芒果热带树，有当地的桉树植物和椤的地方。霜冻能致使这些热带植物暂缓生长并致死亡。

Through the use for reference of the experience of developed country, and linking explicit case, the author analyzes the ratio to Contributory negligence from the two facets of character explain and mathematics explains. We may conclude that the ratio of Contributory negligence is no more then 50% of total liability in compensation responsibilities on mobile vehicles road traffic accident. Namely, whether the victim is in fault or not, the inflictor' liability is no less than 50% of total liability.

在此基础上，通过借鉴发达国家先进立法经验，结合具体案例，从文意解释、数理分析两个方面对过失相抵的比率进行了分析论证，得出结论：在交通事故赔偿责任中过失相抵的比率不得超过50%，即无论机动车一方是否有过错，在受害方对损害的发生有过错因此而减轻机动车一方的责任时，减轻的程度不得超过全部损失的50%。

In research that could be harnessed to speed recovery from stroke or blunt-force trauma to the head, scientists at the University of California, San Francisco, report that mice genetically engineered to have holes in a region of their brain recovered due to the work of stem cells in the area.

这个研究可以利用来加速恢复中风或是外力损害的大脑伤口，三番市的加州大学科学家提出，老鼠的基因遗传规划中，使得大脑部位的损伤恢复归功於大脑干细胞的作用。

In severely multiple injured patients who are in an 'unstable' or 'in extremis' clinical condition, damage control orthopaedics is the current treatment of choice.

对于处于&不稳定&或&濒死&的临床状况的严重多发伤的患者，进行控制损害的骨科手术时目前治疗上的一个选择。

Section 10. No state shall enter into any treaty, alliance, or confederation; grant letters of marque and reprisal; coin money; emit bills of credit; make anything but gold and silver coin a tender in payment of debts; pass any bill of attainder, ex post facto 1.事后的(地,追溯的 law, or law impairing the obligation of contracts, or grant any title of nobility.

任何一州都不得：缔结任何条约，参加任何同盟或邦联；颁发捕获敌船许可状；铸造货币；发行纸币；使用金银币以外的任何物品作为偿还债务的货币；通过任何公民权利剥夺法案、追溯既往的法律或损害契约义务的法律；或授予任何贵族爵位。

Meanwhile, Falkner and LX are while revealing and criticizing clear founder's justice and slaughtering to women of feudal thought, not merely express sympathy to women who are insulted and damaged, but the calm one points out the thought limitation of women while sympathizing with.

与此同时，福克纳和LX在揭露和批判清教主义和封建思想对女性的残害时，并不仅仅对被侮辱和被损害的女性表示同情，而是在同情的同时冷静的指出了女性的思想局限。

I am accused of being overreligious," she said in her quiet, frank manner,"but that does not prevent me thinking the children very cruel who obstinately commit such suicide.""

客人们在卡罗利娜·埃凯家里，举止就文雅一些，因为卡罗利娜的母亲治家很严厉。

Designed by French fashion house Herm è s, this elegant uniform was manufactured in our home, Hong Kong, and was the first without a hat.

由著名品牌 Herm è s 设计，这件高贵的制服是香港本土制造，是我们第一套不配帽子的制服。