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The distress of the people, the laborers without bread, the last Prince de Conde engulfed in the shadows, Brussels expelling the Nassaus as Paris did the Bourbons, Belgium offering herself to a French Prince and giving herself to an English Prince, the Russian hatred of Nicolas, behind us the demons of the South, Ferdinand in Spain, Miguel in Portugal, the earth quaking in Italy, Metternich extending his hand over Bologna, France treating Austria sharply at Ancona, at the North no one knew what sinister sound of the hammer nailing up Poland in her coffin, irritated glances watching France narrowly all over Europe, England, a suspected ally, ready to give a push to that which was tottering and to hurl herself on that which should fall, the peerage sheltering itself behind Beccaria to refuse four heads to the law, the fleurs -de -lys erased from the King's carriage, the cross torn from Notre Dame, Lafayette lessened, Laffitte ruined, Benjamin Constant dead in indigence, Casimir Perier dead in the exhaustion of his power; political and social malady breaking out simultaneously in the two capitals of the kingdom, the one in the city of thought, the other in the city of toil; at Paris civil war, at Lyons servile war; in the two cities, the same glare of the furnace; a crater-like crimson on the brow of the people; the South rendered fanatic, the West troubled, the Duchesse de Berry in la Vendee, plots, conspiracies, risings, cholera, added the sombre roar of tumult of events to the sombre roar of ideas.

人民的疾苦,没有面包的劳动人民,最后一个孔代亲王的横死②,仿效驱逐波旁家族的巴黎而驱逐纳索家族的布鲁塞尔,自愿归附一个法兰西亲王而终被交给一个英格兰亲王的比利时,尼古拉的俄罗斯仇恨,站在我们背后的两个南方魔鬼西班牙的斐迪南和葡萄牙的米格尔,意大利的地震,把手伸向博洛尼亚的梅特涅,在安科纳以强硬手段对付奥地利的法兰西,从北方传来把波兰钉进棺材的那阵无限悲凉的锤子声音,整个欧洲瞪眼望着法国的那种愤激目光,随时准备趁火打劫、落井下石的不可靠的盟国英格兰,躲在贝卡里亚背后拒绝向法律交出四颗人头的贵族院,从国王车子上刮掉的百合花,从圣母院拔去的十字架,物化了的拉斐德,破产了的拉菲特,死于贫困的班加曼·贡斯当,死于力竭的卡齐米尔·佩里埃,在这王国的两个都市中棗一个思想的城市,一个劳动的城市棗同时发生的政治病和社会病,巴黎的民权战争,里昂的奴役战争,两个城市中的同一种烈焰,出现在人民额头上的那种类似火山爆发的紫光,狂烈的南方,动荡的西方,待在旺代的德·贝里公爵夫人,阴谋,颠覆活动,暴乱,霍乱,这些都在种种思潮的纷争之上增添了种种事变的纷起。①在法国一八三○年革命中,拉斐德是自由保王派,波林尼雅克是被推翻的查理十世王朝的内阁大臣。②孔代,波旁家族的一个支系,一八三○年孔代亲王被人吊死在野外,未破案。

PART 1 UNIT 1 B Electrical and Electronic Engineering Basics A Electrical Networks ———————————— 3 Three-phase Circuits A The Operational Amplifier ——————————— 5 UNIT 2 B Transistors A Logical Variables and Flip-flop —————————— 8 UNIT 3 B Binary Number System A Power Semiconductor Devices —————————— 11 UNIT 4 B Power Electronic Converters A Types of DC Motors —————————————15 UNIT 5 B Closed-loop Control of DC Drivers A AC Machines ———————————————19 UNIT 6 B Induction Motor Drive A Electric Power System ————————————22 UNIT 7 B PART 2 UNIT 1 B Power System Automation Control Theory A The World of Control ————————————27 —————29 The Transfer Function and the Laplace Transformation UNIT 2 B A Stability and the Time Response ————————— 30 Steady State————————————————— 31 A The Root Locus ————————————— 32 ————— 33 UNIT 3 B The Frequency Response Methods: Nyquist Diagrams UNIT 4 A The Frequency Response Methods: Bode Piots ————— 34 B Nonlinear Control System 37 UNIT 5 A Introduction to Modern Control Theory B State Equations 40 38 UNIT 6 A Controllability, Observability, and Stability B Optimum Control Systems UNIT 7 A Conventional and Intelligent Control B Artificial Neural Network Computer Control Technology A Computer Structure and Function 42 B Fundamentals of Computer and Networks 43 44 PART 3 UNIT 1 UNIT 2 A Interfaces to External Signals and Devices B The Applications of Computers 46 UNIT 3 A PLC Overview B PACs for Industrial Control, the Future of Control UNIT 4 A Fundamentals of Single-chip Microcomputer 49 B Understanding DSP and Its Uses 1 UNIT 5 A A First Look at Embedded Systems B Embedded Systems Design Process Control A A Process Control System B 50 PART 4 UNIT 1 Fundamentals of Process Control 52 53 UNIT 2 A Sensors and Transmitters B Final Control Elements and Controllers UNIT 3 A P Controllers and PI Controllers B PID Controllers and Other Controllers UNIT 4 A Indicating Instruments B Control Panels Control Based on Network and Information A Automation Networking Application Areas B Evolution of Control System Architecture PART 5 UNIT 1 UNIT 2 A Fundamental Issues in Networked Control Systems B Stability of NCSs with Network-induced Delay UNIT 3 A Fundamentals of the Database System B Virtual Manufacturing—A Growing Trend in Automation UNIT 4 A Concepts of Computer Integrated Manufacturing B Enterprise Resources Planning and Beyond Synthetic Applications of Automatic Technology A Recent Advances and Future Trends in Electrical Machine Drivers B System Evolution in Intelligent Buildings PART 6 UNIT 1 UNIT 2 A Industrial Robot B A General Introduction to Pattern Recognition UNIT 3 A Renewable Energy B Electric Vehicles UNIT 1 A

电路 2 电路或电网络由以某种方式连接的电阻器,电感器和电容器等元件组成。如果网络不包含能源,如电池或发电机,那么就被称作无源网络。换句话说,如果存在一个或多个能源,那么组合的结果为有源网络。在研究电网络的特性时,我们感兴趣的是确定电路中的电压和电流。因为网络由无源电路元件组成,所以必须首先定义这些元件的电特性。就电阻来说,电压-电流的关系由欧姆定律给出,欧姆定律指出:电阻两端的电压等于电阻上流过的电流乘以电阻值。在数学上表达为: u=iR (1-1A-1)式中 u=电压,伏特;i =电流,安培;R =电阻,欧姆。纯电感电压由法拉第定律定义,法拉第定律指出:电感两端的电压正比于流过电感的电流随时间的变化率。因此可得到:U=Ldi/dt 式中 di/dt =电流变化率,安培/秒; L =感应系数,享利。电容两端建立的电压正比于电容两极板上积累的电荷 q 。因为电荷的积累可表示为电荷增量 dq 的和或积分,因此得到的等式为 u=,式中电容量 C 是与电压和电荷相关的比例常数。由定义可知,电流等于电荷随时间的变化率,可表示为 i = dq/dt。因此电荷增量 dq 等于电流乘以相应的时间增量,或 dq = i dt,那么等式(1-1A-3)可写为式中 C =电容量,法拉。

PART 1 Electrical and Electronic Engineering Basics UNIT 1 A Electrical Networks B Three-phase Circuits UNIT 2 A The Operational Amplifier ——————————— 5 B Transistors UNIT 3 A Logical Variables and Flip-flop —————————— 8 ———————————— 3 B Binary Number System UNIT 4 A Power Semiconductor Devices —————————— 11 B Power Electronic Converters UNIT 5 A Types of DC Motors —————————————15 B Closed-loop Control of DC Drivers UNIT 6 A AC Machines ———————————————19 B Induction Motor Drive UNIT 7 A Electric Power System ————————————22 B Power System Automation PART 2 Control Theory UNIT 1 A The World of Control ————————————27 B The Transfer Function and the Laplace Transformation UNIT 2 A B —————29 Stability and the Time Response ————————— 30 ————————————— 32 Steady State————————————————— 31 UNIT 3 A The Root Locus B The Frequency Response Methods: Nyquist Diagrams ————— 33 UNIT 4 A The Frequency Response Methods: Bode Piots ————— 34 B Nonlinear Control System 37 UNIT 5 A Introduction to Modern Control Theory B UNIT 6 State Equations 40 38 A Controllability, Observability, and Stability B Optimum Control Systems UNIT 7 A Conventional and Intelligent Control B Artificial Neural Network PART 3 UNIT 1 Computer Control Technology A Computer Structure and Function B 42 43 44 Fundamentals of Computer and Networks UNIT 2 A Interfaces to External Signals and Devices B The Applications of Computers 46 UNIT 3 A PLC Overview B PACs for Industrial Control, the Future of Control 1 UNIT 4 A Fundamentals of Single-chip Microcomputer B Understanding DSP and Its Uses 49 UNIT 5 A A First Look at Embedded Systems B Embedded Systems Design PART 4 UNIT 1 Process Control A A Process Control System 50 B Fundamentals of Process Control 53 52 UNIT 2 A Sensors and Transmitters B Final Control Elements and Controllers UNIT 3 A P Controllers and PI Controllers B PID Controllers and Other Controllers UNIT 4 A Indicating Instruments B Control Panels PART 5 UNIT 1 Control Based on Network and Information A Automation Networking Application Areas B Evolution of Control System Architecture UNIT 2 A Fundamental Issues in Networked Control Systems B Stability of NCSs with Network-induced Delay UNIT 3 A Fundamentals of the Database System B Virtual Manufacturing—A Growing Trend in Automation UNIT 4 A Concepts of Computer Integrated Manufacturing B Enterprise Resources Planning and Beyond PART 6 UNIT 1 Synthetic Applications of Automatic Technology A Recent Advances and Future Trends in Electrical Machine Drivers B System Evolution in Intelligent Buildings UNIT 2 A Industrial Robot B A General Introduction to Pattern Recognition UNIT 3 A Renewable Energy B Electric Vehicles 2 UNIT 1 A

电路 电路或电网络由以某种方式连接的电阻器,电感器和电容器等元件组成。如果网络不包含能源,如电池或发电机,那么就被称作无源网络。换句话说,如果存在一个或多个能源,那么组合的结果为有源网络。在研究电网络的特性时,我们感兴趣的是确定电路中的电压和电流。因为网络由无源电路元件组成,所以必须首先定义这些元件的电特性。就电阻来说,电压-电流的关系由欧姆定律给出,欧姆定律指出:电阻两端的电压等于电阻上流过的电流乘以电阻值。在数学上表达为: u=iR (1-1A-1)式中 u=电压,伏特;i =电流,安培;R =电阻,欧姆。纯电感电压由法拉第定律定义,法拉第定律指出:电感两端的电压正比于流过电感的电流随时间的变化率。因此可得到:U=Ldi/dt 式中 di/dt =电流变化率,安培/秒; L =感应系数,享利。电容两端建立的电压正比于电容两极板上积累的电荷 q 。因为电荷的积累可表示为电荷增量 dq 的和或积分,因此得到的等式为 u=,式中电容量 C 是与电压和电荷相关的比例常数。由定义可知,电流等于电荷随时间的变化率,可表示为 i = dq/dt。因此电荷增量 dq 等于电流乘以相应的时间增量,或 dq = i dt,那么等式(1-1A-3)可写为式中 C =电容量,法拉。

PART 1 Electrical and Electronic Engineering Basics UNIT 1 A UNIT 2 A UNIT 3 A UNIT 4 A UNIT 5 A UNIT 6 A UNIT 7 A Electrical Networks ———————————— 3 B Three-phase Circuits The Operational Amplifier ——————————— 5 Logical Variables and Flip-flop —————————— 8 Power Semiconductor Devices —————————— 11 Types of DC Motors —————————————15 AC Machines ———————————————19 Electric Power System ————————————22 B Transistors B Binary Number System B Power Electronic Converters B Closed-loop Control of DC Drivers B Induction Motor Drive B Power System Automation PART 2 Control Theory UNIT 1 A B UNIT 2 A UNIT 3 A UNIT 4 A The World of Control ————————————27 Stability and the Time Response ————————— 30 The Root Locus ————————————— 32 The Transfer Function and the Laplace Transformation —————29 B Steady State————————————————— 31 B The Frequency Response Methods: Nyquist Diagrams ————— 33 The Frequency Response Methods: Bode Piots ————— 34 B Nonlinear Control System 37 UNIT 5 A Introduction to Modern Control Theory B B B PART 3 B B B State Equations Optimum Control Systems Artificial Neural Network Computer Control Technology 42 43 44 Fundamentals of Computer and Networks The Applications of Computers 46 40 38 UNIT 6 A Controllability, Observability, and Stability UNIT 7 A Conventional and Intelligent Control UNIT 1 A Computer Structure and Function UNIT 2 A Interfaces to External Signals and Devices UNIT 3 A PLC Overview PACs for Industrial Control, the Future of Control 1 UNIT 4 A Fundamentals of Single-chip Microcomputer 49 B B PART 4 B B B B PART 5 B B B B PART 6 Understanding DSP and Its Uses Embedded Systems Design Process Control 50 52 53 Fundamentals of Process Control UNIT 5 A A First Look at Embedded Systems UNIT 1 A A Process Control System UNIT 2 A Sensors and Transmitters Final Control Elements and Controllers PID Controllers and Other Controllers Control Panels Control Based on Network and Information Evolution of Control System Architecture Stability of NCSs with Network-induced Delay Virtual Manufacturing—A Growing Trend in Automation Enterprise Resources Planning and Beyond Synthetic Applications of Automatic Technology UNIT 3 A P Controllers and PI Controllers UNIT 4 A Indicating Instruments UNIT 1 A Automation Networking Application Areas UNIT 2 A Fundamental Issues in Networked Control Systems UNIT 3 A Fundamentals of the Database System UNIT 4 A Concepts of Computer Integrated Manufacturing UNIT 1 A Recent Advances and Future Trends in Electrical Machine Drivers B B B System Evolution in Intelligent Buildings A General Introduction to Pattern Recognition Electric Vehicles UNIT 2 A Industrial Robot UNIT 3 A Renewable Energy 2 UNIT 1 A

电路 电路或电网络由以某种方式连接的电阻器,电感器和电容器等元件组成。如果网络不包含能源,如电池或发电机,那么就被称作无源网络。换句话说,如果存在一个或多个能源,那么组合的结果为有源网络。在研究电网络的特性时,我们感兴趣的是确定电路中的电压和电流。因为网络由无源电路元件组成,所以必须首先定义这些元件的电特性。就电阻来说,电压-电流的关系由欧姆定律给出,欧姆定律指出:电阻两端的电压等于电阻上流过的电流乘以电阻值。在数学上表达为: u=iR (1-1A-1)式中 u=电压,伏特;i =电流,安培;R =电阻,欧姆。纯电感电压由法拉第定律定义,法拉第定律指出:电感两端的电压正比于流过电感的电流随时间的变化率。因此可得到:U=Ldi/dt 式中 di/dt =电流变化率,安培/秒; L =感应系数,享利。电容两端建立的电压正比于电容两极板上积累的电荷 q 。因为电荷的积累可表示为电荷增量 dq 的和或积分,因此得到的等式为 u=,式中电容量 C 是与电压和电荷相关的比例常数。由定义可知,电流等于电荷随时间的变化率,可表示为 i = dq/dt。因此电荷增量 dq 等于电流乘以相应的时间增量,或 dq = i dt,那么等式(1-1A-3)可写为式中 C =电容量,法拉。

In Alma it states,"Yea, he had been strengthening the armies of the Nephites, and erecting small forts, or places of resort: throwing up banks of earth round about to enclose his armies…the Nephites were taught…never to raise the sword except it were against an enemy… they had cast up dirtround to shield them from the arrows…the chief captains of the Lamanites were astonished exceedingly, because of the wisdom of the Nephites in preparing their places of security…they knew not that Moroni had fortified, or had built forts of security in all the land roundabout …the Lamanites could not get into their forts of security…because of the highness of the bank which had been thrown up, and the depth of the ditch which had been dug round about…they began to dig down their banks of earth…that they might have an equalchance to fight…instead of filling up their ditches by pulling down banks of earth, they were filled up in a measure with their dead…And caused them to erect fortifications that they should commence laboring in digging a ditch round about the land…And he caused that they should build a breastwork of timbers upon the inner bank of the ditch: and they did cast up dirt out of the ditch against the breastwork of timbers".

在阿尔玛书说:『他加强了尼腓人的军队,建造了小型堡垒,或凭藉处所;在周围筑起了堤岸来拱卫他的军队……尼腓人已被教导……除非抵抗敌人,决不举起剑来……他们在周围堆上了污泥来防避拉曼人的箭……这时拉曼人的总队长们非常的吃惊,由於尼腓人在准备他们的安全处所上所表现的智慧……因为他们不知摩罗乃已在周围各地的每一个城巿建筑了防御工事,或防御堡垒……拉曼人除了经由入囗处外,无法进入他们的防御堡垒,因为那土岸已堆得很高,那周围的壕沟已掘得很深……他们就开始去掘他们的土岸,使他们也能得到一条通往他们军队的小路,使他们能有一个均等的作战机会……非但没有推倒土岸来垫没他们的壕沟,反而将他们死者和伤者的身体垫进了不少……并吩咐他们建筑防御工事……他吩咐他们在濠沟的内堤上建造一道木头的胸墙;他们从濠沟中挖出污泥来,靠著木头胸墙堆起来

MOSTLY ,DONATED AT WILL OF EMINENT MONKS ,THIS PIECE OF KAPALA BOWL IS LIGHTLY INCISED WITH IMAGES OF THE SUN ,MOON ,RITUAL CONCH AND A SIX-SYLLABLE INVOCATION IN TIBETAN ,THE BASE IS TRIANGULAR AND THE CORVED WITH LOTUS PETALS ,COILING FOLIATE DESIGN AND EIGHT TREASURES ,THE RIM IS INLAND WITH TURQUOISE AND GEMS ,THE HANDLE IS IN THE SHAPE OF VAJRA ,ON EACH SIDE OF THE BASE ,THERE IS AN IMAGE OF A HUMAN HEAD AND THE REMAINING SURFACE IS MATERIAL WITH OPENWORK COILING LEAF DESIGNS ,MADE OF REFINED MATERIAL AND EXQUISITE CRAFTSMANSHIP ,THIS PIECE IS PERFECT MASTERPICEC.

这件嘎巴拉碗的颅骨外面隐现日、月、法螺和藏文六字真言。碗的托座为三角形,碗盖为椭圆形,都是用纯金制作。金盖上刻有莲瓣,缠枝花卉和八宝纹,盖口边缘上嵌绿松石和珠宝,把手做成金刚杵形。托座上的每一面都有一个人首,其余部分通体镂雕卷叶纹图案。整个嘎巴拉碗选材精细、制作精美、工艺考究、是嘎巴拉碗中的极品之作。

Therapontigonus Miles could walk arm in arm with Vadeboncoeur the grenadier, Damasippus the second-hand dealer would be happy among bric-a-brac merchants, Vincennes could grasp Socrates in its fist as just as Agora could imprison Diderot, Grimod de la Reyniere discovered larded roast beef, as Curtillus invented roast hedgehog, we see the trapeze which figures in Plautus reappear under the vault of the Arc of l'Etoile, the sword-eater of Poecilus encountered by Apuleius is a sword-swallower on the PontNeuf, the nephew of Rameau and Curculio the parasite make a pair, Ergasilus could get himself presented to Cambaceres by d'Aigrefeuille; the four dandies of Rome: Alcesimarchus, Phoedromus, Diabolus, and Argyrippus, descend from Courtille in Labatut's posting-chaise; Aulus Gellius would halt no longer in front of Congrio than would Charles Nodier in front of Punchinello; Marto is not a tigress, but Pardalisca was not a dragon; Pantolabus the wag jeers in the Cafe Anglais at Nomentanus the fast liver, Hermogenus is a tenor in the Champs-Elysees, and round him, Thracius the beggar, clad like Bobeche, takes up a collection; the bore who stops you by the button of your coat in the Tuileries makes you repeat after a lapse of two thousand years Thesprion's apostrophe: Quis properantem me prehendit pallio?

米勒会挽着侍卫华德朋克尔的胳膊,达马西普会在旧货店里流连忘返,万森刺杀苏格拉底正如阿戈拉囚禁狄德罗,格利木·德·拉雷尼埃尔会做油脂牛排正如古尔第吕斯发明烤刺猬。我们见到普劳图斯著作中的高架秋千重现在明星门的气球下面,阿普列乌斯在普西勒遇见的吞剑人便是新桥上的吞刀人,拉穆的侄儿和寄生虫古尔古里翁是一对,埃尔加齐尔请爱格尔弗依把他介绍给康巴色勒斯,罗马的四个纨袴子弟阿尔色西马尔古斯、费德洛木斯、狄阿波吕斯和阿尔吉里帕乘着拉巴突的邮车从拉古尔第①出发,奥吕·热尔在孔格利奥面前没有比查理·诺缔埃在波里希内儿面前待得更长久,马尔东不是母老虎,但是巴尔达里斯卡也绝不是一条龙,滑稽人潘多拉布斯在英格兰咖啡馆里嘲弄享乐人诺曼达纽斯,埃尔摩仁是爱丽舍广场的男高音,并且在他周围有无赖特拉西乌斯扮成波白什②向人募捐,在杜伊勒里广场上掐住你的衣扣、不让你走的那个讨厌人让你在两千年以后还重复着忒斯卜利翁的那句话:&在我有急事时谁突然抓住了我的衣襟?&

For this reason, a novel PPOP was designed and prepared using two side drilling technology and water-insoluble drug gliclazide was employed as model drug. Influencing factors from six aspects were studied which was drug layer formulation, push layer formulation, coating formulation, orifice properties, tableting art and dissolution conditions, respectively, and the difference between the dissolution profiles of novel PPOP and conventional PPOP was also evaluated by similarity factor (f_2). Through determination of the viscosity of drug layer and push layer of the novel PPOP, the mechanism of drug release from novel PPOP was discussed by the help of Poiseuilles law of laminar flow.

因此,本文以难溶性的格列齐特为模型药物,在传统型推拉式渗透泵的基础上,设计并制备了双面打孔型推拉式渗透泵;通过单因素研究从含药层处方、助推层处方、衣膜处方、释药孔性质、压片工艺以及体外释药条件六个方面,对影响双面打孔格列齐特推拉式渗透泵片释药行为的因素进行了详细的考察,同时,应用相似因子法对以上各种因素下双面打孔型推拉式渗透泵和传统型推拉式渗透泵释药特点的异同进行了系统的研究;在此基础上,通过对双面打孔型推拉式渗透泵含药层和助推层黏度的测定,结合流体力学中的Poiseuille层流定律方程,对双面打孔格列齐特推拉式渗透泵片的释药机理进行了较为深入的探讨。

For this reason, a novel PPOP was designed and prepared using two side drilling technology and water-insoluble drug gliclazide was employed as model drug. Influencing factors from six aspects were studied which was drug layer formulation, push layer formulation, coating formulation, orifice properties, tableting art and dissolution conditions, respectively, and the difference between the dissolution profiles of novel PPOP and conventional PPOP was also evaluated by similarity factor (f2). Through determination of the viscosity of drug layer and push layer of the novel PPOP, the mechanism of drug release from novel PPOP was discussed by the help of Poiseuille's law of laminar flow.

因此,本文以难溶性的格列齐特为模型药物,在传统型推拉式渗透泵的基础上,设计并制备了双面打孔型推拉式渗透泵;通过单因素研究从含药层处方、助推层处方、衣膜处方、释药孔性质、压片工艺以及体外释药条件六个方面,对影响双面打孔格列齐特推拉式渗透泵片释药行为的因素进行了详细的考察,同时,应用相似因子法对以上各种因素下双面打孔型推拉式渗透泵和传统型推拉式渗透泵释药特点的异同进行了系统的研究;在此基础上,通·药学论文过对双面打孔型推拉式渗透泵含药层和助推层黏度的测定,结合流体力学中的Poiseuille层流定律方程,对双面打孔格列齐特推拉式渗透泵片的释药机理进行了较为深入的探讨。

For this reason, a novel PPOP was designed and prepared using two side drilling technology and water-insoluble drug gliclazide was employed as model drug. Influencing factors from six aspects were studied which was drug layer formulation, push layer formulation, coating formulation, orifice properties, tableting art and dissolution conditions, respectively, and the difference between the dissolution profiles of novel PPOP and conventional PPOP was also evaluated by similarity factor (f2). Through determination of the viscosity of drug layer and push layer of the novel PPOP, the mechanism of drug release from novel PPOP was discussed by the help of Poiseuille's law of laminar flow.

因此,本文以难溶性的格列齐特为模型药物,在传统型推拉式渗透泵的基础上,设计并制备了双面打孔型推拉式渗透泵;通过单因素研究从含药层处方、助推层处方、衣膜处方、释药孔性质、压片工艺以及体外释药条件六个方面,对影响双面打孔格列齐特推拉式渗透泵片释药行为的因素进行了详细的考察,同时,应用相似因子法对以上各种因素下双面打孔型推拉式渗透泵和传统型推拉式渗透泵释药特点的异同进行了系统的研究;在此基础上,通过对双面打孔型推拉式渗透泵含药层和助推层黏度的测定,结合流体力学中的Poiseuille层流定律方程,对双面打孔格列齐特推拉式渗透泵片的释药机理进行了较为深入的探讨。

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