抵抗的

The peroxisome proliferator-activated receptors play an important role in adipocyte differentiation and fatty acid metabolism, activation of PPAR may induce the differentiation of adipocyte,influence the expression of genes involved in lipogenesis and fatty acid oxidation,eventually lessen ectopic fat accumulation and improve the impaired insulin signaling,so the medicine which targets to the control point of FFA metabolism would be hopeful in the treatment of a cluster of metabolic abnormalities resulted from insulin resistance.

过氧化物酶体增殖物激活受体在脂肪细胞分化、脂肪酸代谢中起重要作用，PPAR及其所调控基因的激活可促进脂肪细胞分化、减少脂质产生、增加脂肪酸氧化，从而减少脂质的异位沉积，进一步改善损伤的胰岛素信号转导通路，逆转胰岛素抵抗。针对脂肪酸合成及氧化的关键调控点的药物可能是今后治疗胰岛素抵抗引发的一系列代谢异常的新的靶点。关键词过氧化物酶体增殖物激活受体；脂肪酸代谢；胰岛素抵抗

Against that time, if ever that time come, When I shall see thee frown on my defects, When as thy love hath cast his utmost sum, Call'd to that audit by advised respects; Against that time when thou shalt strangely pass And scarcely greet me with that sun thine eye, When love, converted from the thing it was, Shall reasons find of settled gravity,-- Against that time do I ensconce me here Within the knowledge of mine own desert, And this my hand against myself uprear, To guard the lawful reasons on thy part: To leave poor me thou hast the strength of laws, Since why to love I can allege no cause.

为抵抗那一天，要是终有那一天，当我看见你对我的缺点蹙额，当你的爱已花完最后一文钱，被周详的顾虑催去清算账目；为抵抗那一天，当你像生客走过，不用那太阳--你眼睛--向我致候，当爱情，已改变了面目，要搜罗种种必须决绝的庄重的理由；为抵抗那一天我就躲在这里，在对自己的恰当评价内安身，并且高举我这只手当众宣誓，为你的种种合法的理由保证：抛弃可怜的我，你有法律保障，既然为什么爱，我无理由可讲。

Against that time, if ever that time come,When I shall see thee frown on my defects,When as thy love hath cast his utmost sum,Call'd to that audit by advised respects;Against that time when thou shalt strangely passAnd scarcely greet me with that sun thine eye,When love, converted from the thing it was,Shall reasons find of settled gravity,--Against that time do I ensconce me hereWithin the knowledge of mine own desert,And this my hand against myself uprear,To guard the lawful reasons on thy part: To leave poor me thou hast the strength of laws, Since why to love I can allege no cause.

为抵抗那一天，要是终有那一天，当我看见你对我的缺点蹙额，当你的爱已花完最后一文钱，被周详的顾虑催去清算账目；为抵抗那一天，当你像生客走过，不用那太阳--你眼睛--向我致候，当爱情，已改变了面目，要搜罗种种必须决绝的庄重的理由；为抵抗那一天我就躲在这里，在对自己的恰当评价内安身，并且高举我这只手当众宣誓，为你的种种合法的理由保证：抛弃可怜的我，你有法律保障，既然为什么爱，我无理由可讲。

Some researches show the resistin is an important incretion related to fatness,insulin resist...

有研究显示抵抗素是一种与肥胖、胰岛素抵抗和糖尿病有关的重要激素，现就抵抗素与胰岛素抵抗及2型糖尿病的关系简要综述。

O Lord our God, help us to tear their soldiers to bloody shreds with our shells; help us to cover their smiling fields with the pale forms of their patriot dead; help us to drown the thunder of the guns with the shrieks of their wounded, writhing in pain; help us to lay waste their humble homes with a hurricane of fire; help us to wring the hearts of their unoffending widows with unavailing grief; help us to turn them out roofless with little children to wander unfriended the wastes of their desolated land in rags and hunger and thirst, sports of the sun flames of summer and the icy winds of winter, broken in spirit, worn with travail, imploring Thee for the refuge of the grave and denied it – for our sakes who adore Thee, Lord, blast their hopes, blight their lives, protract their bitter pilgrimage, make heavy their steps, water their way with their tears, stain the white snow with the blood of their wounded feet!

主啊我们的上帝，帮我们用炮弹将对方的士兵撕裂成血淋淋的碎片，让他们美好的战场上覆盖著他们爱国者的苍白尸骸，让他们因疼痛而扭曲的伤者所发出的尖叫，盖过我们如雷的枪炮声。协助我们以狂焰摧毁他们卑微的家园，帮我们用无助的忧伤让他们未参与抵抗的寡妇心痛不止，协助我们逼迫她们带著小孩无家可归，褴褛饥渴，不受欢迎地流浪在荒芜土地的废墟当中。受到夏阳的光焰与冬季冰冷寒风的嘲弄，心灵破碎，因艰苦而憔悴，向汝恳求死亡之庇护而不可得。因为我们敬重主的缘故，所以您摧毁他们的希望，抹杀他们的生灵，拖延他们苦涩的行程，让他们步履沉重，泪水洒满行经之路，让白雪因受伤的双足而沾染血迹！

Aim To establish an in vitro insulin resistant model of HepG2 cells and 3T3-L1 adipocyte and to screen drug in vitro.

目的 在体外建立肝胰岛素抵抗细胞模型和脂肪细胞胰岛素抵抗模型，并初步应用于中药有效成分的胰岛素抵抗活性筛选中。

the coronary heart disease exist the insulin resistance, hyperinsulinism and lipin metabolism abnormity, they are all the dangerous factor which the coronary heart disease occurs, the insulin resist and the coronary heart disease clinical symptom serious degree are related.

冠心病存在胰岛素抵抗、高胰岛素血症及脂质代谢的异常，它们都是冠心病发生的危险因素，胰岛素抵抗与冠心病临床症状的严重程度相关。关键词：冠心病；胰岛素抵抗；血脂

The results showed as:(1)Gegen decreases fasting insulin and insulin resistance index and increases insulin sensitive index of rats of insulin resistance induced by dexamethasone significantly;(2)Gegen can improve glucose tolerance of rats of insulin resistance but not to alloxan indued diabetes mice;(3)Gegen increases glucose intake of 3T3-L1 adipocytes and improves the insulin resistance of 3T3-L1 adipocytes induced by dexamethasone significantly;(4)Gegen can activate peroxisome proliferator- activated receptor gamma, make it bind to PPAR response elements;(5)Gegen can up-regulate mRNA expression of PPAR v ,aP2 and adiponectin.

结果表明：①葛根显著降低地塞米松诱导的胰岛素抵抗大鼠血清胰岛素水平和胰岛素抵抗指数，升高胰岛素敏感指数，改善大鼠的胰岛素抵抗；②葛根显著改善胰岛素抵抗大鼠的糖耐量，但对四氧嘧啶糖尿病小鼠的糖耐量没有明显的作用；③葛根显著增加胰岛素抵抗3T3-L1脂肪细胞对葡萄糖的摄取，改善地塞米松诱导的3T3-L1脂肪细胞的胰岛素抵抗；④葛根能促进HepG2肝癌细胞过氧化物酶体增殖物激活受体γ与靶基因的特异DNA序列结合，对PPARγ及其下游基因的转录具有激活作用；⑤葛根能够促进PPARγ及其下游基因脂肪酸结合蛋白(aP2)、脂联素mRNA的表达。

But how far the seizing on countries already peopled, and driving out or massacring the innocent and defenseless natives, merely because they differed from their invaders in language, in religion, in customs, in government, or in color; how far such a conduct was consonant to nature, to reason, or to Christianity, deserved well to be considered by those, who have rendered their names immortal by thus civilizing mankind.

但是，究竟能够在多大的范围内，在已经有人定居的国家中获取财产，并驱赶或猎杀那些无罪和毫无抵抗的原居民，仅仅因为他们在语言，宗教，习俗，政府或肤色上不同于入侵者；这样的行为究竟在多大的程度上能够与自然，理性或基督教相一致，这些问题应当很好的根据先人——这些人的名字已经被文明的人类视为不朽——加以考虑。

The structure of the utility model is that the brush holder(1) is connected with the metal connector(3)on which the stainless brush bristl(4) is moulded .The utility model has the advantages of corrosion-resistance, rust-resistance, unhairing-resistance, no loosing,long service life, clean, beautiful appearance, economy and practicability.

实用新型的结构是炭刷架(1)用(3)连接不锈的刷子bristl的金属连接器(4)被铸造实用新型有腐蚀抵抗、铁锈抵抗， unhairing抵抗，没有疏松，长的产品使用期限，干净，美好的出现、经济和可实行性的好处。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。