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Abstract] Objective To explore the relationship between epicardial adipose tissue and insulin resistance in overweight and obesity population.

目的 研究超重和肥胖成人胰岛素敏感性、胰岛素抵抗及心外膜脂肪组织和胰岛素抵抗的关系。

Objective To establish obesity model of rats and study the effect of astragalus polysaccharides on insulin resistance in vivo.

目的 建立肥胖胰岛素抵抗大鼠模型,观察黄芪多糖对肥胖大鼠胰岛素抵抗的影响。

Objective To evaluate whether the homeostasis model assessment is a reliable index in Chinese type 2 diabetic patients.

目的评价HOMA法胰岛素抵抗指数是否适合于中国 2型糖尿病胰岛素抵抗的临床应用。

However, the reports on target tissue of myoblast in insulin resistance skeletal muscle cell models are few.

背景:在胰岛素抵抗的细胞模型中,以游离脂肪酸诱导3T3-L1脂肪细胞和高胰岛素诱导的HepG2肝癌细胞最为常见,对分布最为广泛靶组织骨骼肌的胰岛素抵抗模型报道较少。

Resistless hostages; No other colony showed such supine, selfish helplessness in allowing her own border citizens to be mercilessly harried- Theodore Roosevelt.

没有抵抗能力的人质;没有哪一个殖民地表现出如此不抵抗的、自私的无能,听任她自己的国民遭受残忍的掠夺——瑟尔多·罗斯福。

The Relationship between Epicardial Adipose Tissue and Insulin Resistance in Overweight and Obesity Adults.

目的 研究超重和肥胖成人胰岛素敏感性、胰岛素抵抗及心外膜脂肪组织和胰岛素抵抗的关系。

So hyperinsulinemia may step up blood pressure.These explain IR have some invariable effect in pathogenesis of eclampsism. Sex hormone binding globulin is a species of sterin haptoglobulin which is form from liver.The level of SHBG is an indirect index of balanate between androgen and estrogen.Not only hyperinsulinemia but also IR have intimate relationship with blood serum SHBG level.

高胰岛素血症、胰岛素抵抗与血清SHBG水平均有着密切关系,胰岛素对调节SHBG的代谢具有重要意义,胰岛素水平升高使SHBG生成减少,造成体内性激素水平紊乱,导致糖、脂肪、胰岛素代谢障碍,提示SHBG是高胰岛素血症、胰岛素抵抗的一个特有标志。

Conclution The researches on the diabetic mice of insulin resistant shew that CLA could improve the insulin resistant.The mechanism may be related to deceasing TNF α and FFA.

对实验性胰岛素抵抗小鼠的研究证明CLA有改善胰岛素抵抗的作用,其作用机制之可能是通过抑制机体FFA及TNF-α水平而发挥作用。

Methods Thirty male rats were divided into 3 groups:control, high-fat fed, swimming group.The control rats were fed with common diet for 24 weeks.The high fat-fed group and swimming group were fed with high fat diet containing 55% saturated free fatty acid for 24 weeks . The swimming group began swimming for 50-60 minutes from 17th week to 24th week .The change of insulin sensitivity was valued by euglycomic-hyperinsulin clamp.

通过长期高脂高热量饮食喂养使大鼠具有胰岛素抵抗的特征,进行游泳干预治疗8周,高胰岛素正葡萄糖钳夹技术评价大鼠外周胰岛素抵抗程度,用RT-PCR检测大鼠骨骼肌肌肉素和GLUT4 mRNA表达的变化以及肌肉甘油三酯沉积度、胰岛素、血脂等代谢指标的差异。

OBJECTIVE: Intrauterine growth retardation is associated with insulin resistance in later life but the mechanism remains unclear. To explore the molecular mechanism of insulin resistance, we determined the expression of gluconeogenic enzymes as well as the expression of transcription factor which promotes gluconeogenesis in the liver of IUGR rats.

目的:宫内生长受限(IUGR和成年胰岛素抵抗密切相关,但其发生机制不清楚,该研究通过检测IUGR子鼠肝脏中糖异生关键酶及可促进糖异生的转录因子的表达,探讨IUGR个体发生胰岛素抵抗的分子机制。

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