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So, Z-1 was named IEM106 and regarded as a live oral cholera vaccine candidate eliciting both antibacterial and antitoxic immunity.

以上结果表明,Z-1无毒,免疫家兔可诱导抗菌抗毒免疫,具有很好的保护作用,可以作为霍乱弧菌抗菌抗毒口服活菌苗候选株,命名为IEM106。

Essential oil was extracted from the petroleum ether-soluble fraction of the leaves showed having antibacterial activity. It was demonstrated that the essential oil has significant antibacterial activity and the activity of the petroleum ether-soluble fraction is attributed to it. The constituents of the essential oil were analysized by GC-MS.10 relatively abundant components were identified on the basis of MS, among which Geranlgeraniol was found in the essential oil of Perilla frutescens leaves for the first time.

对具有抗菌活性的紫苏叶石油醚萃取物进一步精制,从中提取出挥发油,通过抗菌测试证明紫苏叶挥发油具有良好的抗革兰氏阳性菌和革兰氏阴性菌活性,是紫苏叶石油醚萃取物抗菌活性的来源;采用GC-MS对紫苏叶挥发油进行了成分分析,得到10种含量较高的主要化合物,其中的牻牛儿基牻牛儿醇首次在该植物挥发油中被发现。

Since the establishment of the company, we have adhered to the management concept of "Take quality as the foremost, regard people as the soul". With the advanced imported equipment, well-chosen material, professional production management and sincere after-sales service, we have grown rapidly in the competitive market and developed into a key enterprise with an annual output of over one million square meters in laminated floor production. Our products now include flooring of crystal surface, macro-embossed surface, mirror surface, solid wood, clone solid wood as well as the new generation of light catalyst antibiotic series, among which are feature silk series, tree bark-like series, water-resistant series and our latest innovation, the fantasy series. Over 100 varieties are available. Our products have already been exported to the United States, Canada and some European countries. In China,"Shan Shan Lubao" is becoming a well-known brand among the consumers.

本公司是一家专业生产高档强化复合地板厂家,自公司成立伊始,一直秉持"以质为本,以人为魂"的经营理念,依靠先进的进口设备,精选的优等材料,专业的生产管理和完善的售后服务在竞争激烈的市场里脱颖而出,在短短几年中迅速发展成为一家年产强化地板百余万平方的国力强化地板生产骨干企业:目前公司产品已拥有水晶面、浮雕面、镜面、赛实木、克隆实木、新一代的光触媒抗菌羽丝面系列、光触媒抗菌树皮纹系列、光触媒抗菌防水系列、光触媒抗菌静音系列和最新科技创新产品、光触媒抗菌梦幻系列等,百余种花色,产品远销美国、加拿大、欧洲等国家,在国内,"杉杉绿宝"亦逐渐成为业内及消费者心目当中较知名的品牌。

The minimum inhibitory concentration of the eight fishery antibacterial drugs are determined and its inhibitory action and bactericidal effects on the Aeromonas hydrophila used respectively and combinedly are compared by using double dilution method and inhibition zone method.

采用二倍稀释法及抑菌圈法测定了目前常用的8种抗菌渔药对嗜水气单胞菌的最低抑菌浓度,比较了这8种抗菌渔药单独用药与联合用药对嗜水气单胞菌的抗菌效果。

Com-pound 11 showed best antifungal activity with broad antifungal spectrum and proved to be more active against Cryptococcus neo-formans, C andida albicans, Microsporum lanosum and Trichophyton rubrum than ketoconazole.

化合物11的抗菌谱最广,抗真菌活性最高,对新型隐球菌、白色念珠菌、羊毛状小孢子菌和红色毛癣菌的抗菌活性比酮康唑高,有进一步开发的价值。

objective to study the risk factors on esbl producing strains of k.pneumoniae and e.coli.methods aprospective survey on esbl producing strainsof k.pneumoniae and e.coli for a36-month period.results the resistance rates ofe.coli were:98.08%for ctx,73.08%for amc.the resistance rates of k.pneuˉmonialwere;95.74%for ctx,97.87%for amc.the use rate of third generation cephalosporins was much higher than those of esbls nonproducing strains(p.05).it induce esbls that3rd generation cephalosporins were used extensive.after strenghtening the antibiotic controls,esbls detection rate has gone down.conclusion the factors of infection of esbl-producing strains were the severity diseases,cellular immunological condition,improper medical manipulations.to prevent esbl-producing strains,reasonable antibiotics usage may be the effective measure.

目的 分析临床大肠埃希菌及肺炎克雷伯菌产esbls的危险因素,并加以控制。方法前瞻性监测产esbls菌的情况,并对感染者进行临床调查。结果产esbls的大肠埃希菌、肺炎克雷伯菌的耐药率头孢噻肟钠为98.08%和95.74%,阿莫西林+棒酸为73.08%和97.87%,产esbls菌感染者头孢第三代的使用率(70.21%)显著高于非产esbls菌感染者(39.47%)(p.05);第三代头孢的大量使用诱导esbls的产生。通过加强抗感染药物的使用管理esbls检出率开始下降。结论严重的基础病、高龄、机体免疫力低下,长期住院者是esbls菌感染的易感宿主,皮质激素、化疗及介入性疗法是esbls感染的高危因素。滥用抗感染药是产生esbls的重要因素,合理使用抗感染药是防止esbls产生的主要措施。

New antifungal agents have been developed over the past years based on the discovery of many new target sites of Candida albicands. For example, Echinocandins, aiming at the cell wall of Candida albicands, showed strong antifungal activities to fluconazole resistant candidas and fungal biofilm. Moreover, because β-glucan synthase does not exist on the cell membrane of mammalian cells, Echinocandins has a low toxicity and a promising clinical future. Though the mechanism of Histatin is not clear, it has strong activity not only on candida resistant of polyene and azole, but also to Candida parapsilosis, Candida krusei and Cry ptococcus neoformans. Berberine and Ocimum gratissimum L. were also found to have prominent anti-fungi activities.

近年来相继提出了许多抗白念珠菌药物作用的新靶点并成功开发出一些活性强大,疗效确切的抗真菌药,如以真菌细胞壁为靶点开发出棘白菌素类药物卡泊芬净、米卡芬净等,该类药物主要抑制β-葡聚糖合成酶,体外对氟康唑耐药的念珠菌属及真菌生物被膜表现出强大的抗菌活性,又由于β-葡聚糖合成酶在哺乳类动物细胞内不存在,故具有高效低毒的临床效果,是一极具前途的新型抗真菌药;以真菌细胞膜为靶点开发出Histatin类药物,虽然作用机制目前还不完全明了,但其作用不同于临床常用的多烯类和氮唑类,并已经发现Histatin5对两性霉素B和氮唑类耐药的念珠菌有效,并且对非白念珠菌如光滑念珠菌、克柔氏念株菌、隐球菌等也有杀灭作用;通过对植物药物的研究发现黄连素和丁香罗勒Ocimum gratissimum L。

Have been finished with physical germ-resistant finish agent of WS-8810, flax fabric can acquire satisfactory antibacterial effect. This treatment can not only make this fabric keep antibacterial effect for a long time, but also avoid generating new kinds of bacteria disserving human ecology environment; therefore it will not come into conflict with its ""green consumption "" concept, so it can be used safely .

4麻织物经物理抗菌卫生整理剂WS-8810处理后能取得较理想的抗菌效果;这种处理不仅可使抗菌织物长期保持抗菌效果,还可避免产生新的菌种危害人类的生态环境;因此,不会与其&绿色消费&产生冲突,可以放心地使用。

Through measuring MIC and bacteriostasis diameter, the inhibited abilityof antimicrobials to bacterium and funguses is assessed. Through measuring optical density, inhibited ability of single antimicrobials to algaes si assessed. And, the variation law of antibacterical effect of antimicrobials is researched with variation of time and pH.

通过测定最低抑菌浓度MIC值和抑菌圈直径考察单体抗菌剂对菌类的抑制能力,通过对水样光密度的测定考察单体抗菌剂对藻类的抑制能力,并研究抗菌剂抗菌效果随时间及pH值的变化规律。

On the basis of ecologic balance, developing the complex biological preparation as a goal, we first explored two compatibly antagonists to control the leaf disease of forest plant and hoped this two antagonistic fungi could play a cooperative role in controlling the pine needle blight. The main research results were as follows: 1 , The dual test showed the two antagonistic fungi(Gliocladiutm virens ,Bacillus firmus)had some differences to Pestalotia funerea in the inhibition mode. The role of G virens to the P.funerea, mainly displayed the competition in the nutrition and space, but the B. firmus had the distinct inhibition zone to the P.

本研究以生态平衡为理论基础,开发复合生物制剂为目标,首次将两种亲和拮抗菌用于森林植物叶部病害,以期两种复合拮抗菌在松属植物赤枯病防治中发挥协同作用,其主要研究结果如下: 1、对峙培养显示两种颉抗菌(Gliocladium virens、Bacillus firmus)对赤枯病菌的抗生方式有一些差异。G.virens对P.funerea的作用,主要表现为营养与空间上的竞争,无抑菌圈;而B.firmus对P.funerea有明显的抑菌圈(平均6mm),对峙培养4-5d后菌丝逐稀疏、干枯、变黄。

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