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The prediction of secondary structure showed that Family chensirin-2 and dybowsin-2 are extended coils, and the rest families have one or two a-helix where polar amino acids are located on one side of the helix wheel and apolar amino acids on the other side, attaching an amphiphilic property to the whole helix.

除dybowsin-2和chensirin-2家族为自由卷曲抗菌肽外,其余各类抗菌肽均能形成一段至两段a-螺旋结构,极性氨基酸和非极性氨基酸分别位于螺旋轮的两侧,使蝶旋呈两亲性。

MICs of the combination of cefoperazone or ceftazidime and levofloxacin were determined by the microdilution chequer board technique,interpretation of the results was made by calculation of FIC.

结果:头孢哌酮、头孢他啶和左氧氟沙星联合用药对铜绿假单胞菌的体外抗菌协同作用为35 5%~38 7%,相加作用为41 9%~45 2%,无关作用为16 1%~22 6%,无拮抗效应。

These two traditional Chinese medicine has a strong antibacterial activity and, more importantly, they have an advantage that lower toxicity than traditional disinfectant drug - Formocresol, CP. In order to help in the developmentof new strategies to prevent or eliminate the infection byE. faecalis, thereby improving treatment results in endodontics and give a reference to clinical application, In this research , using traditional Drug formocresol and the current most respected calcium hydroxide ( calcium hydroxide mixed with propylene glycol ) as the conventional control, we investigated the antimicrobial activity of Chinese herbs cinnamic aldehgd and Chinese gallnut against E. faecalis in root canals in vitro.

上述两种中药都具有很强的抗菌作用,更重要的是它们作为中药具有较传统消毒药物—甲醛甲酚、樟脑酚毒副作用小的优点,本研究通过离体牙根管消毒实验,并用传统消毒药物甲醛甲酚及当前最受推崇的氢氧化钙制剂做为常规对照,对两种中药的抗粪肠球菌性能进行评价,以期探讨更有效且安全的抑制或杀灭粪肠球菌的方法,提高根管治疗的成功率,为临床应用提供一定参考。

Faecalis, thereby improving treatment results in endodontics and give a reference to clinical application, In this research , using traditional Drug formocresol and the current most respected calcium hydroxide (calcium hydroxide mixed with propylene glycol) as the conventional control,we investigated the antimicrobial activity of Chinese herbs cinnamic aldehgd and Chinese gallnut against E.

上述两种中药都具有很强的抗菌作用,更重要的是它们作为中药具有较传统消毒药物—甲醛甲酚、樟脑酚毒副作用小的优点,本研究通过离体牙根管消毒实验,并用传统消毒药物甲醛甲酚及当前最受推崇的氢氧化钙制剂做为常规对照,对两种中药的抗粪肠球菌性能进行评价,以期探讨更有效且安全的抑制或杀灭粪肠球菌的方法,提高根管治疗的成功率,为临床应用提供一定参考。

Isatin has therapeutic effects on Parkinson's disease, aging, hyperlipemia, anti-epileptic, tumor, epilepsy antibacterial, anti-virus and other biological activity.

靛红的合成、结构和药理活性研究倍受关注,已有报道证明靛红具有抗帕金森病、抗衰老、降血脂、抗癫痫、抗癌、抗菌、抗病毒等多种生物活性。

Basic physical-chemistry properties such as solubility ,surface activity, micelle thermodynamic property ,solubilization and the applied properties such as moisture adsorbability ,water retentivity, microemulsion , antibacterial activity , antitumor activity have been studied systematiclly.

研究了该类表面活性剂的基本物化性能如溶解性、表面活性、胶束热力学性质、增溶性能以及吸湿保湿性、微乳性能、抑菌抗菌性、抗肿瘤活性等应用性能。

Natural monoclonal antikeratin antibody IgM 3B4 can inhibit the adhesion of Candida albicans to the malpighian cells, human buccal epithelial cells and endothelial cells of fetal umbilical vein, and decrease the invasion of Candida albicans due to its inhibitory action on the formation of Candida albicans germ tube,which indicates that natural antibody IgM plays a role in the natural immunity against yeast infection.

单克隆天然抗角蛋白抗体IgM 3B4在体外能够抑制白念珠菌芽管形成,能够抑制白念珠菌与人角质形成细胞、人口腔黏膜上皮细胞、胎儿脐静脉内皮细胞的粘附,从而降低白念珠菌的侵袭力,提示天然抗体IgM在机体抗真菌感染的天然免疫中可能具有积极的作用。

RESULTS: It was found that the different concentrations of natural monoclonal anti-keratin antibody IgM 3B4 could inhibit Candida albicans germ tube formation and adhesion of Candida albicans to malpighian cells, human buccal epithelial cells and endothelial cells of fetal umbilical vein.

单克隆天然抗角蛋白抗体IgM3B4在体外能够抑制白念珠菌芽管形成,能够抑制白念珠菌与人角质形成细胞、人口腔黏膜上皮细胞、胎儿脐静脉内皮细胞的粘附,从而降低白念珠菌的侵袭力,提示天然抗体IgM在机体抗真菌感染的天然免疫中可能具有积极的作用。

Keratin antibody IgM 3B4. CONCLUSION: Natural monoclonal anti??keratin antibody IgM 3B4 can inhibit the adhesion of Candida albicans to the malpighian cells, human buccal epithelial cells and endothelial cells of fetal umbilical vein, and decrease the invasion of Candida albicans due to its inhibitory action on the formation of Candida albicans germ tube,which indicates that natural antibody IgM plays a role in the natural immunity against yeast infection.

单克隆天然抗角蛋白抗体IgM 3B4在体外能够抑制白念珠菌芽管形成,能够抑制白念珠菌与人角质形成细胞、人口腔黏膜上皮细胞、胎儿脐静脉内皮细胞的粘附,从而降低白念珠菌的侵袭力,提示天然抗体IgM在机体抗真菌感染的天然免疫中可能具有积极的作用。

This dissertation aims at finding anticancer and antibacterial polynuclear complexes targeting DNA with high activity and low toxicity. Sixteen compounds were synthesized, and characterized by means of X-ray single crystal diffraction, elemental analysis, molar conductivity and IR, and the influencing factors on structures of the compounds have been investigated. The actions of these compounds to DNA were also investigated by spectral, electrochemical and hydromechanical methods.

本论文以DNA为靶点,以寻找新结构类型的高效、低毒的抗癌、抗菌多核配合物为目标,从分子设计出发,共合成得到了16个化合物的单晶结构,对其进行了结构表征,探讨了结构影响因素,并研究了其超分子结构;采用紫外-可见吸收光谱法、荧光光谱法、电化学和粘度法,从分子水平上研究了所得配合物与DNA的相互作用;在细胞水平上,研究了草酰胺桥联双核配合物的抗菌和抗肿瘤活性。

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