抗菌

The fermentation broth of one actinomycete strain ACMA006 strongly inhibited growth of many tumor cells and some microorganisms, but its cytotoxicity to human normal cells were weak.

海洋放线菌ACMA006的发酵产物具有很强的抗肿瘤活性和较好的抑菌效果，但对人正常细胞毒性较弱。

We further evaluated the synergistic cytotoxicity of TRAIL in combination with actinomycin D, cisplatin and paclitaxel in A549 cell lines in vitro and in vivo.

本实验选择了人肺腺癌A549细胞瘤株作为我们实验研究的对象，通过TRAIL对人肺腺癌A549细胞诱导凋亡研究，在A549的荷瘤裸鼠的动物模型上研究了其体内的抗肿瘤活性，并进一步研究了TRAIL与化疗药物放线菌素D(actinomycin D，Act D)、紫杉醇和顺铂(cisplatin，CDDP)的联合作用对人肺腺癌A549细胞的体外协同抗肿瘤活性，通过化疗药物协同增强TRAIL抗肿瘤活性作用机制的初步研究，为降低临床化疗药的用药量，减轻其对机体的不良反应提供一定的理论基础。

We summarized the treatment on endotoxaemia according to the different period of endotoxaemia and the theory of traditional Chinese medicine diclecpical in terms of from modern medicine and traditional Chinese medicine. Endotoxaemia ; Medication ; Immunity,active ; Depurate blood ; Therapy of traditional chinese medicine ; Differentiation of sydromes and prerequisite of treatment

目前对内毒素血症的治疗尚缺乏成熟的经验，主要是采取综合措施，包括控制菌血症、减少内毒素产生和吸收、抗内毒素药物的应用、拮抗内源性介质的作用以及清洗、吸附等。1 内毒素血症的现代医学治疗1.1 内毒素血症形成期1.1.1抑制内毒素的生物合成1.1.1.1抗

Results Compound albicanyl caffeate displayed strong antifungal property with MIC 4 μg/ml, while moderate antifungal effects (MIC16 μg/ml)were observed with compounds emodin, resveratrol, 3,4'-difluorostilbene, 2,2'-difluorostilbene and 2,3',5'-trifluorostilbene. Pakyonol, catechin, ampelopsin A, 3,4,4'-trihydroxyl- bibenzyl, 2,4'-difluorostilbene, 4-fluorostilbene,2-methyloxy-4'-fluorostilbene showed lower activity with MIC 32 μ g/ml.

结果化合物albicanyl caffeate对白色念珠菌表现出强的抗真菌活性，MIC为4μg/ml；而化合物大黄素、白藜芦醇、3，4'-二氟二苯乙烯、2，2'-二氟二苯乙烯及2，3'，5'-三氟二苯乙烯显示出中等程度的抗真菌活性，MIC为16μg/ml；双联苄pakyonol、多酚类儿茶素、白藜芦醇二聚体野葡萄素A、3，4，4'-三羟基联苄、2，4'-二氟二苯乙烯、4-氟二苯乙烯及2-甲氧基-4'-氟二苯乙烯显示出较弱的抗真菌活性，MIC为32 μg/ml。

The author in recent years used the traditional Chinese medicine phlegm hot clear treatment acute pneumonia,the research indicated that,the refrigeration antidote in vitro bacteriostasis,the sterilization,the neutral bacteriotoxin and the anti-viral function effective concentration was in vivo achieves with difficulty,its treatment function was the anti-infection,the anti-inflammation,the disintoxicating,the promotion organism immunity function common result.

笔者近年来采用中成药痰热清治疗急性肺炎，研究表明，清热解毒药在体外的抑菌、杀菌、中和细菌毒素和抗病毒作用的有效浓度是体内难以达到的，其治疗作用是抗感染、抗炎、解毒、促进机体免疫功能的共同结果。

Objective To explore the effect of different anticoagulants on quantitative assays for HBV DNA using real-time PCR technique. Methods Peripheral blood samples were obtained from 40 patients infected with HBV. Serum and plasma samples from three kinds of anticoagulants such as heparin, trisodium citrate, and dipotassium EDTA were stored at -20℃.

目的 探讨用实时荧光定量PCR技术检测乙型肝炎病毒DNA拷贝时，不同抗凝剂对乙型肝炎病毒DNA定量检测的影响方法采集40例乙型肝炎患者血液，分别置于不含抗凝剂及含肝素钠、枸缘酸钠、EDTA-K2抗凝剂的无菌试管中，分离血清和血浆后于-20℃冰箱保存备用。

The current antifungal agents used in clinics usually have severe side-effects, it is necessary to seek for new antifungal agents with known or new mechanisms. China has abundant resources in traditional Chinese medicine, therefore exploition of new antifungal agents therefrom is a feasible way.We have screened antifungal activities of 14 ethanolic extracts from traditional Chinese medicines and 21 natural products by using Saccharomyces cerevisiae GL7 and Prototheca wickerhamii as the model microoranganisms. Among the TCMs tested, Cortex Phellodendri, Flos Caryophylli, Fructus Mume, Rhizoma Coptidis and Radix Sophorae tonkinensis showed high antifungal activity. This study layed certain foundation for the development of new antifungal agents.

为了开发中药资源，从传统中药中寻找有抗真菌活性的天然药物并阐明其作用机理以利于临床应用，论文对14种生药乙醇提取物及21种生药化学成分利用啤酒酵母突变型GL7（Saccharomyces cerevisiae GL7）和威克海姆原藻作为模式菌种进行了抗真菌活性筛选，其中黄柏、丁香、乌梅、黄连和山豆根等有很好的抑菌活性，为进一步研究开发成新的抗真菌药奠定了基础。

Results In this 323 strains of fungus, candida albicans was the main species, according for 63.8％, candidas tropicalis for 22.3％, and candidasglabrata for 7.4％.The resistance rate to 5 antifungals was ordinalhere:5FC 1.9％, AP 2.2％, KE 5.6％, IT 10.2％, FL 12.1％.

结果：323株真菌中，白色念珠菌、热带念珠菌、光滑念珠菌等分别占63.8%、22.3%和7.4%；对5种常用抗真菌药的耐药率排序依次为：5氟胞嘧啶1.9%、两性霉素B2.2%、酮康唑5.6%、依曲康唑10.2%、氟康唑12.1%。

A resistant mutant of Rhizoctonia solani to Jinggangmycin was obtained by being treated with Jinggangmycin taming for 24 generations.

水稻纹枯病菌野生菌株(Jgm^8)在含井冈霉素的PSA培养基上连续驯化24代，获得－株抗井冈霉素的突变菌株Jgm

Endophytic Bacillus subtilis strain B47,which was isolated from the stem of tomato, was an efficient biological control agent on tomato bacterial wilt. A strain resistant to streptomycin derivative of wild strain B47 was used to study the colonization ability and fluctuation of populations in soil and tomato organs, and its biological control on tomato bacterial wilt.

从番茄茎分离的内生枯草芽孢杆菌菌株B47对番茄青枯病有较好的防治作用，利用该菌株的抗链霉素突变菌株，研究其在土壤和番茄植株根，茎中的定殖能力及其对番茄青枯病的防治作用。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失