抗菌

A developmental focus was placed upon the intermediates of the drug such as cephalosporin,antihypertensive,antilipemic,antiulcer,antineoplastic,antiviral,antineuralgic,vitamin and amino acid.

重点发展第二、三、四代头孢菌素中间体、第三、四代喹诺酮类药物中间体、新型抗高血压药物中间体、新型抗高血脂药物中间体、抗溃疡药物中间体、抗癌药及抗病毒药物的中间体、中枢神经药物中间体、手性药物中间体、维生素及各种氨基酸。

Using the obtained antiserum as the first antibody, and the monoclonal antibody 4C11 as the collator, the specificity of the antiserum was tested by Western blotting and indirect-ELISA with the Yak recombinant mature PrP, GST fusion protein, the extract of brain and the bacterium protein.

以自制抗血清为一抗，单抗4C11为对照，对牦牛重组成熟朊蛋白、GST蛋白、脑组织提取物和菌体蛋白进行Western blotting检测和间接ELISA试验，验证自制抗血清的特异性。

One patient taking infliximab developed tuberculosis and one developed histoplasmosis. Five patients (four taking infliximab and one taking placebo) developed cancer. New autoimmune disorders developed in two patients taking infliximab and one patient taking placebo. Two patients developed optic neuritis and one developed a multifocal motor neuropathy; all three were taking the study drug.

英夫利昔单抗组1例患者发生结核病，1例发生组织胞浆菌病。5例患者(英夫利昔单抗组4例，安慰剂组1例)发生癌症。2例英夫利昔单抗组患者和1例安慰剂组患者新发自身免疫性疾病。2例患者发生视神经炎，1例发生多灶性运动神经病；这3例患者均服用了英夫利昔单抗。

According to the ability of the field isolates of Gibberella zeae to grow on the PSA with varying carbendazim concentrations, three sensitivity levels of isolates were determined in vitro. The sensitive isolates could grow at 0.5 μg/ml, but could not grow at 100 μg/ml. The high resistant isloates could grow faster than R at 50 μg/ml, and also could grow at 100 μg/ml.No low resistant isolates, that could grow fast at 1.4 μg/ml but could not grow at 50 μg/ml, were found among the field isolates.

根据在0.5、1.4、50、100 μg/ml等不同浓度的含药PSA平板上能否生长，将玉蜀黍赤霉田间菌株对多菌灵的敏感性划分为：敏感、中抗和高抗等3个水平，其中S菌株在0.5 μg/ml浓度下能生长，但在≥1.4 μg/ml浓度下生长受到完全抑制；R菌株在1.4 μg/ml浓度下能快速生长，在50 μg/ml浓度下能缓慢生长，但在≥100 μg/ml浓度下不能生长；HR在≥100 μg/ml浓度下仍能生长。

In vitro this oil showed a better antifungal activities, under the concentration of 2.0 μL/mL in media it could totally inhabit the growth of Crytococcus neoformans, S porothrix schenckii, Microsporum lanosum, M. Gy pseum and Chaetomium globosum.

该挥发油具有一定的体外抗真菌活性，在培养基油浓度小于2.0 μL/mL的情况下，能够完全抑制新型隐球菌、申克氏孢子丝菌、羊毛状小孢子菌、石膏样小孢子菌和球毛壳霉等皮肤真菌的生长繁殖。

Result The phytopathogenic fungus Pythium aphanidermatum was isolated; 7 strains of antagonistic actinomycete, which had obvious inhibitory effects on Pythium aphanidermatum were screened. The inhibitory ring of No.8 strain was 13.3 mm, and reached 88.3% when cultivated for 120 h.

伽师甜瓜猝倒病的病原菌为瓜果腐霉；筛选出7株对瓜果腐霉具有显著拮抗性的生防放线菌，其中8号放线菌对瓜果腐霉的拮抗环宽度为13.3mm，其无菌发酵滤液对瓜果腐霉的抑菌率在培养120h时高达88.3%。

Using Sarcina lutea as original strain,a ethionine and zinc chloride-resistant mutant was screened after treated with UV.

通过对谷胱甘肽新产生菌———藤黄八叠球菌进行紫外诱变处理，筛选到一株抗乙硫氨酸和氯化锌的抗性菌株，该突变株发酵生产谷胱甘肽的产量比出发菌株提高268.9%。

Based on the backgrounds above-mentioned, our research intends to understand the incidence and the distribution of Candidas in the fungal infection cases and among healthy volunteers, mensurate the MIC of several antifungal agents against Candida ioslates in oral cavity, and to understand the difference of sensitivity in order to helpclinicians select proper antigungal agents, and discuss the relationship between antifungal susceptibility and clinical effect.

基于上述研究背景，本试验的研究目的是了解当前口腔念珠菌感染患者和健康人口内菌株的检出及分布情况；测定几种常用抗真菌药物对念珠菌口内分离株的最低抑菌浓度，了解其药敏感性有无差别，为临床用药提供参考；初步探讨MIC值与临床疗效的关系。

The results showed that the three disparate treated substances have no visible antibacterial effect to E. coli , but a obvious effect to Staphylococcus aureus with inhibition of about 10 bacteriostasis units; have dissimilar effects to 10 kinds of fungi among the total kinds, and have a good inhibitory effect to Cytospora.coccodesHughes with fungistasis rate above 65%. After the gel filtration and activity detection, 50mM ammonium acetate was screened out as the more suitable eluents, the crudes were separated into strikingly unlike parts with obviously different antimicrobial activity.

结果表明，大蜡螟抗菌物质对大肠杆菌没有明显的抑制作用，而对金黄葡萄球菌抑制作用明显，抑菌活性单位在10左右；对10种植物病原真菌均有不同的抑菌活性，其中对苹果树皮腐烂病菌的抑制率达到65%以上；经过凝胶过滤分离，及对分离组分的抑菌活性测定，筛选出较合适的洗脱液为50mM乙酸铵，各分离组分抑菌活性差异明显，粗提物被分成了两个差异显著的部分。

Result A strain of Pseudomonas cepacia was detected in 1.6% compound quaternary ammonium disinfectant before application. The amount of the germ was 1.21×105cfu/ml. The strain had the similar resistance to chlorine-containing disinfectants and glutaraldehyde compared with Staphy aureus. The contaminated disinfectant could still thoroughly destroy the antigenicity of HBsAg with 60min's contact after diluted for 5-20 times.

结果 该洋葱假单胞菌对氯和戊二醛的抗力与大肠杆菌和金黄色葡萄球菌接近，污染样液除菌后1 000倍稀释对大肠杆菌和金黄色葡萄球菌仍有较好的杀菌效果，20倍稀释可完全破坏HBsAg抗原性，和抑制枯草杆菌黑色变种芽胞的生长，1 600倍稀释可抑制白色念珠菌生长，而原液则不能抑制分离菌株的生长。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。