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In this review, we presented novel agents with potential for the treatment of tuberculosis, which through natural product screening, design and synthesis of new drugs and structure modification of antituberculous agents; we also described advance in molecular biology of tuberculosis and the development of antituberculous targets.

文中综述了近年来通过天然物筛选、新药设计合成以及对现有抗结核药物的再修饰等途径,发现的一些有抗结核活性的化合物,以及结核杆菌分子生物学和抗结核治疗靶点的研究进展。

Objective:To find the chemical standard product of Euphorbia fischeriana Steud.

目的:从狼毒大戟中寻找抗结核的有效成分作为化学对照品。

nodular dermal vasculitis in lower extremities are often seen clinically in middle-age women, and are evoked by many causes. Some laboratory examinations have abnormal outcomes and we think these are related with autoimmune reactions of nodular dermal vasculitis. We can make diagnosis with clinical character of erythema and nodose lesions in lower extremities, laboratory examinations and histopathology inspection. Antibiotics, non- Steroid anti-inflammatory drugs, anti-tubercle drugs and corticosteroids are effective drugs.

结节型皮肤血管炎多发于中年女性;结节型皮肤血管炎病因复杂,可能是由于细菌、真菌、病毒、结核、药物等所引起,也可为某些全身性疾病的皮肤表现;实验室指标异常改变可能与疾病免疫反应有关;结节型皮肤血管炎诊断以双下肢红斑结节性损害的临床特点,结合实验室及组织病理学检查可确诊分型;结节型皮肤血管炎针对病因选用抗生素、非甾体抗炎药、抗结核药、皮质类固醇激素等治疗有效。

Traditional anti-tuberculosis therapy combined with intrathecal injection is a simple and effective mehod in patients with tubercular meningitis.

常规抗结核治疗联合鞘内给药治疗结核性脑膜炎能取得较好效果,该方法是治疗结核性脑膜炎的一种简单、有效的方法。

Part V: The effects of antituberculosis drugs on the bone cells Objective: To observe the effects of antituberculosis drugs in anti-TB bone on the bone cells.

第5部分:抗结核药物对骨细胞的作用目的:观察抗结核骨中使用的抗结核药物对骨细胞的影响。

In order to investigate new methods to the detection of Mycobacterium tuberculosis and diagnostic value of FQ-PCR in the detection of DNA in Mycobacterium tuberculosis, FQ-PCR was used to detect DNA of Mycobacterium tuberculosis in body fluid from 68 patients with tuberculosis and 68 patients without tuberculosis and it was also compared with the two methods of smear acid-fast stainning and antituberculotic antibody.

为探讨结核分枝杆菌检测的新途径及其FQ-PCR技术在结核分枝杆菌DNA诊断中的实用价值,运用FQ-PCR技术对68例结核病患者和68例非结核病患者体液进行结核分枝杆菌DNA测定,并与涂片抗酸染色及ELISA—抗结核抗体法进行比较。

The two groups were given the same regime, treatment group forty cases were given herb Feifu-decoction one dosis, twice per day. Control group forty cases were only given anti-tuberculosis drugs. The course of treatment was one month.

两组患者在给予相同抗结核药物治疗的基础上,治疗组40例,每日1剂中药肺腑汤剂,分2次给药;对照组40例只给予口服抗结核药物治疗,疗程均为1个月。

Patients in treatment group (n=70) were treated by combination of Jieheling and phthisical. The changes of lesions absorption, cavitates closure, bacterium of phlegm negative transform and clinical symptoms were observed in two groups.

将140例复治菌阳肺结核患者随机分为2组,治疗组70例,在采用常规抗结核药治疗的同时,配合结核灵进行治疗;对照组70例,单纯予常规抗结核药治疗。

Objectives To investigate the mechanism of generation of L-form of M.tuberculosis and its significance on the development,diagnosis and treatment of tuberculosis. Methods M. tuberculosis was inoculated into the non-high osmotic medium with rifampin, isoniazid or ethambutol and then the L-form was observed by microscopy daily.

目的 观察常用抗结核药物对结核分支杆菌L型的诱导作用以及结核分支杆菌L型在非高渗透压培养基内的某些特性及其抗菌药物敏感性,探讨结核分支杆菌L型形成的机制及其在结核病的发生、诊断及治疗上的意义。

Objective To study the distribution of rifampicin, isoniazid in tissues of patients with tuberculosis wrist for the sake of providing given guide toward operation and postoperative chemotherapy.

目的 研究腕关节结核病灶中抗结核药物的分布特点,为腕关节结核化疗与手术治疗方法的改进提供理论依据。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

The new PS20 solar power tower collected sunlight through mirrors known as "heliostats" to produce steam that is converted into electricity by a turbine in Sanlucar la Mayor, Spain, Wednesday.

聚光:照片上是建在西班牙桑路卡拉马尤城的一座新型PS20塔式太阳能电站。被称为&日光反射装置&的镜子将太阳光反射到主塔,然后用聚集的热量产生蒸汽进而通过涡轮机转化为电力