抗糖尿病的

Quinoline and its derivatives display a wide spectrum of biological activities such as antimalarial, antibacterial, antidiabetic, and anti-inflammatory.

Quinoline衍生物有著广泛的生物活性，例如：抗菌、抗疟疾、控制糖尿病及抗发炎等等。

Dialectic retinopathy,the most common microvascular complication of diabetes is the leading cause of blindness.Many drugs have been used to prevent the development of it.The primary drug treatment includes the intensive control of blood glucose,blood pressure and the reducing ofblood-fat. The directed against drug treatment includes advanced glycation end products inhibitor, vascular endothelial growth factor inhibitor,inhibitive factor promoter,supplement of inosital, aldose reductase , protein kinase C inhibitors, GH inhibitors,improvement of retinal microcirculation, DAG-PKC inhibitor, ginkgo blibe extract, antioxidant.

糖尿病视网膜病变是最常见的糖尿病微血管病变，目前有很多致力于延缓糖尿病视网膜病变的药物研究，包括严格控制血糖、血压，降低血脂的基础药物治疗，以及蛋白非酶糖基化终末产物抑制剂、血管内皮生长因子抑制剂和抑制因子促进剂、肌醇的补充及醛糖还原酶抑制剂的应用，及蛋白激酶C抑制剂、生长激素抑制素、改善视网膜微循环药物、DAG-PKC抑制剂、银杏叶提取物、抗氧化剂等针对性药物的应用。

PPAR γ agonist displayed obvious renoprotective action,the mechanism was complicated, it could improve the metabolism of glucose ang lipid, depress blood preasure, protect small vessels endothelium,improve the system activity of blood clotting and fibronolysis, antiinflammation, otherwise the action was more obvious with the time passed, at the early stage the effective was better,so encourage the patients to take the medicine earily; when the patients with the mediate reanl function failure, Avandia did not display significantly renoprotective action, side reaction had no difference compared to the control group,was not necessary to regulate the dose of Avandia.But because of the sample size was small, we needed a biger sample to confirm the results. We confirmed that Prol2Ala had no difference in control case,diabetic nephropathy group and diabete group,In diabetic group and diabetic nephropathy group, Ala carriers compared to noncarrier all kinds of biochemical indicators were not different,Prol2Ala did not have association with diabete and diabetic nephropathy. But because of the sample size was small, weneeded a biger sample to confirm the results.

PPARγ激动剂对糖尿病肾病具有明显的保护作用，保护作用的机制是多方面的，除了改善糖脂代谢，降低血压外，还具有保护小血管内皮，改善凝血和纤溶系统活性，抗炎症等多方面的作用，且作用随着用药时间的延长而日趋明显，在疾病的早期应用效果更佳，故提倡早期用药；对伴有慢性肾功不全的患者，罗格列酮对肾脏靶器官的保护作用显现的并不明显，但副作用与对照组无明显差异，不用根据肾功情况调整用药，但由于样本量较小，上述结论尚需大样本进行进一步证实；本实验研究得出Prol2Ala变异在健康对照组、糖尿病组及糖尿病肾病组均无显著差异，糖尿病组及糖尿病肾病组临床各生化指标与Prol2Ala变异亦无相关性，Prol2Ala与糖尿病及糖尿病肾病不相关。

Objective To approach the therapeutic effectiveness of early intervening treatment of diabetic footwith ciwujia injection and decoagulant.Methods 100 diabetes mellitus with early pedopathy was divided into treatment group and controlled group with the ADA diagnostic criteria in 1997. 50 patients of the treatment group were subjected to intervening treatment with ciwujia injection and peroral decoagulant(persantine、enteric-coated aspirin), while 50patients of the control group received peroral VitB1、VitB6、complexdanshen.

目的 观察刺五加注射液及抗凝剂对糖尿病足早期干预治疗的影响方法将符合1999年WHO诊断标准的100例糖尿病合并早期足病变的患者分两组：干预治疗组50例，对照组50例，在控制血糖、血压、糖尿病教育的基础上，干预组予以静滴刺五加注射液及口服抗凝剂治疗，对照组为口服VitB1、VitB6、复方丹参片治疗。

Comparing with diabetes control group , the level of SOD and MDA increased obviously in 1.5 g/kg.d and 3.0g/kg.d Marine collagen peptide group P＜0.05 or P＜0.01 ,while the level of MDA and NO decreased markedly P＜0.05 or P＜0.01; the antioxygen capability did not change significatively in 0.75g/kg.d dose Marine collagen peptide.

鉴于糖尿病患者抗氧化应激功能失调与氧自由基反应增强和抗氧自由基酶类活性降低密切相关，本文就具有抗氧化活性和提高免疫力等功效的海洋胶原肽对2型糖尿病大鼠血清抗氧化应激指标表达的影响进行实验研究。

Comparing with diabetes control group , the level of SOD and MDA increased obviously in 1.5 g/kg.d and 3.0g/kg.d Marine collagen peptide group P＜0.05 or P＜0.01 ,while the level of MDA and NO decreased markedly P＜0.05 or P＜0.01; the antioxygen capability did not change significatively in 0.75g/kg.d dose Marine collagen peptide.

鉴于糖尿病患者抗氧化应激功能失调与氧自由基反应增强和抗氧自由基酶类活性降低密切相关，本文就具有抗氧化活性和提高免疫力等功效的深海胶原肽对2型糖尿病大鼠血清抗氧化应激指标表达的影响进行实验研究。

Tongluofangji could improve the antioxidative ability, inhibit lipid peroxide and protect the aorta thoracica endothelia in diabetic rats,and further proved diabetic angiopathy belongs to Luobing.Tongluofangji would be a new kind of drugs for the prophylaxis and treatment of the diabetic chronic complication.

通络方剂能提高糖尿病大鼠机体抗氧化能力，抑制脂质过氧化，对糖尿病所致的大鼠血管内皮损害具有一定的保护作用，进一步证明糖尿病血管病变属于络病范畴，通络方剂有望成为糖尿病慢性并发症的防治药物。

The relationship between the type of ligands, composition of the complexes, structure of the complexes with the properties of lowering blood sugar was studied and the corresponding law was concluded, the research will provide certain theoretical basis for the deep research of amino-acid vanadyl complexes with anti-diabetic properties.

研究配体的类型、配合物的组成、配合物的结构与降低血糖功能之间的关系并总结出相应的规律，为具有抗糖尿病功能氨基酸氧钒配合物的深入研究提供一定理论基础。

Objective:To study the differences in the types of cerebral infarction,blood coagulation function and outcomes between the infracted patients with and without diabetes mellitus.

目的：探讨脑梗死合并2型糖尿病与单纯脑梗死之间的血脂水平、凝血功能及预后的差异。方法：将70例脑梗死合并2型糖尿病病人设为糖尿病组，62例单纯脑梗死病人设为非糖尿病组，两组均给予相同的抗凝、抗血栓、脱水、降压和改善微循环等治疗。

The delicate balance between pro-oxidant and antioxidant forces in the body could determine the outcome of many disease processes that are associated with aging, including cardiovascular disease, degenerative joint diseases and diabetes, as well as the decline in efficiency of the immune system's ability to protect against infectious agents.

之间的微妙平衡亲氧化剂和抗氧化剂的力量在人体中可确定的结果，许多疾病过程相关的老化现象，包括心血管疾病，退化性关节疾病和糖尿病，以及为减少，效率的免疫系统的能力，以防止传染病的代理商。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。