抗精神病的

It is therefore useful in the treatment of a variety of neuropsychological or affective disorders, dopaminergic blockade disorders and extrapyramindal side effects caused by the use of conventional neuroleptic agents.

该药在键合D_4受体亚原型方面具有亲和性和选择性，所以在治疗多种神经心理上的或情感方面的错乱以及其它多巴胺能的障碍性错乱是有用的，也能治疗使用传统的抗精神病药而导致的锥体外系副作用。

A drug derived from phenothiazine that has anti-psychotic effects and is used as a sedative and tranquilizer.

从苯巴比妥鲁米那中提取的被用作镇静剂和止痛药的有抗精神病作用的药。

Objective To explore the role of body antioxidation capacity in the pathogenesis of psychosis and its clinical significance.

目的 探讨机体抗氧化能力在精神病发病机理中的作用及其临床意义。

In this study 60 female schizo- phrenic patients were treated,Gr- oup A was treated with antipsych- otic drugs combining with insulin hypoglycemia,while group B was only treated with antipsychotic d- rugs,They were opserved by the rating methods of IV grade thera- peutic effect, The results show that in both groups there is no statistical sign- ificance in comparison of the imm- ediate effect,the feature of contr- olling the prominient psychiatric symptoms,the time needed for the same level of improvement,t...

结果提示，在即期疗效、好转方式，达到同一缓解水平所用治疗日数和抗精神病药的日使用量、BPRS总分和各因子分的减分幅度以及总分和除焦虑忧郁项以外的其它四项因子的减分速度等方面，合并治疗均无明显优点，其达显进疗效反而慢于对照组，而对焦虑忧郁症状的缓解较快于对照组。

ResultsThe similarity, digit span, digit sign, picture, picture remembrance , vision renew in patients after treatment were higher than those before treatment ( P .05). As to the total number, total error number and persistent error number of WCST (P . 05).DiscussionIn this study, thirty - five patients who took Risperdal treatment have cognitive function disorder in different disagree, after 12 weeks, nine items among twelve items reflecting cognitive function have significant difference , indicate cognitive deficits in schizophrenia are reversible and related to new type antipsychotic drug .

实验结果 35例患者在服用利培酮治疗前和治疗12周后认知功能的测验的比较，在相似性、数字广度、数字符号、填图、图片回忆、视觉再生测验中有显著性差异（P＜O.05L在＊qT中，总测验数、总错误数、持续错误数均有显著性差异沙＜o.05人讨论本研究中35例病人应用利培酮治疗前均有程度不同的认知功能损害，经12周治疗后，反映认知功能的十二项分测验中的九项均与治疗前呈显著性差异，提示精神分裂症的认知功能损害具有可逆性，且与新型抗精神病药物密切相关。

That has anti-psychotic effects and is used as a sedative and tranquilizer.

从苯巴比妥鲁米那中提取的被用作镇静剂和止痛药的有抗精神病作用的药。

Personality traits were evaluated by Eysency Personality Questionnaire that was compiled by Eysency and revised by Gong. Standard scores of Psychoticism, Extraversion and Neuroticism were calculated, and taking 50 points as a boundary. Each dimension was assigned into 2 grades non-psychotic type (P0) psychotic type (P≥50), introversion type (E0), extraversion type (E0), non-nervous type (N0) and nervous type (N≥50). 5 mL ulnar vein blood was obtained without adding decoagulant, and then serum was removed. Genome DNA was extracted from blood clot by conventional chloroform for PCR analysis. PCR product was sequenced by pyrophosphoric acid. SNP was determined by PSQ96 MA sequenator. Allele frequency was analyzed by mass spectrometry.

人格评定采用Eysency编制，龚耀先修订的艾森克人格问卷、计算精神质，内外问，神经质3个个性维度的标准分，并以50分为界，将各维度分为两个等级：非精神病倾向型（精神质0）、精神病倾向型（精神质≥50）；内倾型（内外向0），外倾型（内外向≥多50）；非常经质倾向型（神经质0），神经质倾向型（神经质≥50）取肘静脉血5 mL，不加抗凝剂，弃血清，血凝块常规酚氯仿提取基因组DNA，进行PCR分析PCR产物应用焦磷酸测序PSQ96 MA测序仪进行SNP检测，用质谱法进行及等位方基因频率分析。

To date, there have been a few clinical trials exploring the efficacy of NMDA enhancers as adjuvant therapy. For instance, D-serine (an endogenous agonist of the NMDA-glycine site) and sarcosine (N-methylglycine, an endogenous glycine transporter I inhibitor) are not only well-tolerated but also synergistic in improving positive, negative symptoms and cognitive function in chronic patients receiving typical or atypical antipsychotics. We just completed the first trial applying NMDA enhancers in acutely exacerbated schizophrenia patients with collaboration with Harvard University, and the results showed that sarcosine was superior to D-serine in efficacy.

目前已有将NMDA促进剂作为辅助用药的临床研究，例如，D-serine (一种内生性NMDA-glycine site致效剂)、sarcosine (即N-methylglycine，一种内生性glycine transporter I 抑制剂)等，结果显示它们不但安全，且能加强传统及新一代抗精神病剂对慢性患者活性、负性症状及认知功能的疗效；我们日前与哈佛大学合作完成目前唯一将NMDA促进剂用於急性患者的研究，结果发现，sarcosine的疗效又优於D-serine。

It is concluded that the percentage of abnormal EKG between patients taking different kinds of APDs is some different. But in statistical sense, the difference is no significant.

不同的抗精神病药物引发患者心电图异常的比例有一定差异，但并不构成明显的统计差异。

It is concluded that the percentage of abnormal EKG between patients taking different kinds of APDs is some different. But in statistical sense, the difference is no significant.

不同的抗精神病药物引发患者心电图异常的比例有定差异，但并不构成明显的统计差异。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。