抗神经毒素

The effects could be attributed to the selective action of BmK Ⅰ on the TTX-S Na〓 channel: slowing the inactivation process of Na〓 channel, increasing the amplitude of peak Na〓 currents; 2 BmK abT, a new-type neurotoxin with higher sequence homology to β-type scorpion neurotoxin, was found to slow the inactivation process of Na〓 channel and prolong the duration of action potential in DRG neurons.

这些结果提示BmK IT2和BmK AS-1的外周抗伤害性效应可能是通过它们对小直径DRG神经元外周游离末梢即C纤维末梢上的TTX-S和TTX-R钠通道的门控调节所致，且BmK IT2对角叉菜胶致炎大鼠较强的抗伤害性作用可能是由于它对TTX-R钠通道较高的敏感性所致。二。特异性钠通道调制剂-东亚钳蝎神经毒素的电生理特征。

Most recently the group is mainly engaged in some important protein related to health and diseases, including human Cul3 ubiguitin ligase complex, some effectors and eritical proteins of pathogenic bacterical, and a series proteins critical in aromatic degradation pathway of microbal.

近年来的主要研究对象为一些与天然免疫相关的重要蛋白，包括一系列天然神经毒素，抗微生物蛋白，抗肿瘤蛋白和抗病毒蛋白，以及还开展了造血干细胞和痢疾杆菌的结构基因组学研究。

When the effect ofNTP was examined after depletion of monoamines in the spinalcord by intrathecal neurotoxins, the antiallodynic and antihyperalgesiceffects were still observed after serotonergic denervation,but not after noradrenergic denervation.

鞘内给予神经毒素耗竭脊髓单胺递质后检查 NTP 的作用时，去除5羟色胺能神经支配后 NTP 的抗触觉性痛感和抗痛觉过敏作用仍然存在，但是去除去甲肾上腺素能神经支配后则消失。

Antinociception and VGSC-modulation of BmK IT2 and BmK AS—1. The results from nociceptive flexion reflex and plantar radiation heat showed: BmK IT2 (a depressant insect-selective neurotoixn) and BmK AS-1 (a new-type β-1ike neurotoxin) have significant antinociceptive effects on rat peripheral nerve system. The antinociceptive effects of BmK IT2 on the carrageenan-inflamed rats were significantly stronger than those on the normal rats. Whole-cell patch-clamping showed: Both TTX-S and TTX-R Na〓 currents induced from rat DRG neurons were significantly inhibited by BmK IT2 and BmK AS—1, and BmK IT2 was more sensitive to TTX-R than TTX-S component. All the results suggested: the peripheral antinociception of BmK IT2 and BmK AS—1 might be attributed to the inhibitory effects of them on the TTX-S and TTX-R Na〓 channel located on the peripheral ends of rat DRG neurons with small diameter.

中文题名特异性钠通道调制剂－长链蝎神经毒素的药理功能研究副题名外文题名 The study of pharmacological function of the specific modulators on voltage-gate Na+ channel-long chain scorpion neurotoxin 论文作者谭智勇导师吉永华研究员学科专业生理学研究领域\研究方向学位级别博士学位授予单位中国科学院上海生命科学研究院学位授予日期2002 论文页码总数93页关键词神经毒素毒理学电压门控钠通道东亚钳蝎钠通道调制剂馆藏号BSLW /2003 /R338 /22 本论文工作利用细胞和行为药理技术系统地研究了东亚钳蝎长链神经毒素的抗伤害性效应、对电压门控钠通道的电生理调制作用、改变胞内离子浓度的效应，并分析了相关的药理功能机制。

This one mode pays close attention to network credence foundation of the businessman very much.

这一模式非常关注商人的网络信用基础。

Cell morphology of bacterial ghost of Pasteurella multocida was observed by scanning electron microscopy and inactivation ratio was estimated by CFU analysi.

扫描电镜观察多杀性巴氏杆菌细菌幽灵和菌落形成单位评价遗传灭活率。