抗真菌的

Objective To investigate the effects of cinnamaldehyde and citral on DNA and RNA of Aspergillus flavus and A. fumigatus cells and their mechanisms. Methods A.

目的 研究肉桂醛、柠檬醛对黄曲霉和烟曲霉细胞DNA、RNA水平的影响，以期探明其抗真菌的作用机制。

They have so many antibacterial and anti-viral and anti-fungal compounds on their backs.They ve even isolated certain kinds of medicine that can slow down the HIV virus.

它们的背上含有非常多的抗细菌、抗病毒和抗真菌的化合物，我们甚至还能从中分离出某种可以降低艾滋病毒活力的药物。

GAFP-1 cDNA and its deduced amino acid sequence share high homology with the mannose binding lectins from Epipactis helloborine, Listera ovata and snowdrop.

本文报道GAFP-1 cDNA的克隆并首次报道其全长序列，这为将GAFP-1应用于植物抗真菌病害基因工程奠定基础，并有助于揭示其抗真菌的作用机理。

If a child is suffering from tinea capitis, doctors will open a number of anti-fungal cream applied to affected area outside.

如果孩子患了头癣，医生会开一些抗真菌的药膏以外涂于患部。

Results Compound albicanyl caffeate displayed strong antifungal property with MIC 4 μg/ml, while moderate antifungal effects (MIC16 μg/ml)were observed with compounds emodin, resveratrol, 3,4'-difluorostilbene, 2,2'-difluorostilbene and 2,3',5'-trifluorostilbene. Pakyonol, catechin, ampelopsin A, 3,4,4'-trihydroxyl- bibenzyl, 2,4'-difluorostilbene, 4-fluorostilbene,2-methyloxy-4'-fluorostilbene showed lower activity with MIC 32 μ g/ml.

结果化合物albicanyl caffeate对白色念珠菌表现出强的抗真菌活性，MIC为4μg/ml；而化合物大黄素、白藜芦醇、3，4'-二氟二苯乙烯、2，2'-二氟二苯乙烯及2，3'，5'-三氟二苯乙烯显示出中等程度的抗真菌活性，MIC为16μg/ml；双联苄pakyonol、多酚类儿茶素、白藜芦醇二聚体野葡萄素A、3，4，4'-三羟基联苄、2，4'-二氟二苯乙烯、4-氟二苯乙烯及2-甲氧基-4'-氟二苯乙烯显示出较弱的抗真菌活性，MIC为32 μg/ml。

Streptomyces strain 24# was isolated from our lab to produce secondary metabolites which could strongly antibiotic to 30 plant pathogenic fungi, such as Helminthosporium sorokinum, fusarium graminearum Schw., Valsa mali, etc.

本实验室通过对一株产生抗真菌活性物质的链霉菌24#抗菌谱的测定，发现其对30余种植物病原真菌有显著拮抗作用，其次生代谢产物对病菌菌丝有断裂、溶壁、缢缩等致畸效应。

The Arabidopsis CYP81F2 gene encodes a P450 monooxygenase that is essential for the pathogen-induced accumulation of 4-methoxyindol-3-ylmethyl glucosinolate, which in turn is activated by the atypical PEN2 myrosinase (a type of β-thioglucoside glucohydrolase) for antifungal defense.

拟南芥CYP81F2基因能都编码一种P450单加氧酶，这对4甲氧基-3二甲胺基芥子油甙的病原体诱导积累物是十分重要的。反过来，它也能被非典型PEN2黑芥子酶激活，以产生抗真菌的防御作用。

New antifungal agents have been developed over the past years based on the discovery of many new target sites of Candida albicands. For example, Echinocandins, aiming at the cell wall of Candida albicands, showed strong antifungal activities to fluconazole resistant candidas and fungal biofilm. Moreover, because β-glucan synthase does not exist on the cell membrane of mammalian cells, Echinocandins has a low toxicity and a promising clinical future. Though the mechanism of Histatin is not clear, it has strong activity not only on candida resistant of polyene and azole, but also to Candida parapsilosis, Candida krusei and Cry ptococcus neoformans. Berberine and Ocimum gratissimum L. were also found to have prominent anti-fungi activities.

近年来相继提出了许多抗白念珠菌药物作用的新靶点并成功开发出一些活性强大，疗效确切的抗真菌药，如以真菌细胞壁为靶点开发出棘白菌素类药物卡泊芬净、米卡芬净等，该类药物主要抑制β-葡聚糖合成酶，体外对氟康唑耐药的念珠菌属及真菌生物被膜表现出强大的抗菌活性，又由于β-葡聚糖合成酶在哺乳类动物细胞内不存在，故具有高效低毒的临床效果，是一极具前途的新型抗真菌药；以真菌细胞膜为靶点开发出Histatin类药物，虽然作用机制目前还不完全明了，但其作用不同于临床常用的多烯类和氮唑类，并已经发现Histatin5对两性霉素B和氮唑类耐药的念珠菌有效，并且对非白念珠菌如光滑念珠菌、克柔氏念株菌、隐球菌等也有杀灭作用；通过对植物药物的研究发现黄连素和丁香罗勒Ocimum gratissimum L。

The current antifungal agents used in clinics usually have severe side-effects, it is necessary to seek for new antifungal agents with known or new mechanisms. China has abundant resources in traditional Chinese medicine, therefore exploition of new antifungal agents therefrom is a feasible way.We have screened antifungal activities of 14 ethanolic extracts from traditional Chinese medicines and 21 natural products by using Saccharomyces cerevisiae GL7 and Prototheca wickerhamii as the model microoranganisms. Among the TCMs tested, Cortex Phellodendri, Flos Caryophylli, Fructus Mume, Rhizoma Coptidis and Radix Sophorae tonkinensis showed high antifungal activity. This study layed certain foundation for the development of new antifungal agents.

为了开发中药资源，从传统中药中寻找有抗真菌活性的天然药物并阐明其作用机理以利于临床应用，论文对14种生药乙醇提取物及21种生药化学成分利用啤酒酵母突变型GL7（Saccharomyces cerevisiae GL7）和威克海姆原藻作为模式菌种进行了抗真菌活性筛选，其中黄柏、丁香、乌梅、黄连和山豆根等有很好的抑菌活性，为进一步研究开发成新的抗真菌药奠定了基础。

The result of the antibacterial and antifungal assay shows that thirty five strains of the endofungi (58.3% of total tested strains) have antibacterial activities, the active strains mostly belong to sterile groups (51.4% of active strains), Penicillium (8.6%), Aspergillus (8.6%), Fusarium(8.6%); forty nine strains (81.7% of total tested strains) have antifungal activites, most of them belong to sterile groups (44.9% of active strains), and Gloeosporium (17.1%).

结果 共有35株内生真菌具有抗细菌活性，占待侧菌株总数的58.3%，其中以不产孢类、青霉属、曲霉属、镰孢属为主，分别占活性菌株总数的 51.4%、8.6%、8.6%、8.6%；共有49株内生真菌具有抗真菌活性，占待侧菌株总数的81.7%，其中以不产孢类和盘长孢属为主，分别占活性菌株总数的44.9%、17.1%。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失