抗痫的

Its antiepileptic effect is certain but the underlying mechanism is unknown.

它的抗痫作用早已明确，但其抗痫机制至今不明。

Radioimmunologic method was used to evaluate the influence of th e complex prescription of regulating the spleen and stomach on the pentylenetetr azole kindled rats and changes of the opioid peptides concentration in th e brain.

为了研究调理脾胃复方的抗痫作用，本实验采用放免法观察大鼠PTZ点燃以及服用调理脾胃复方治疗后，脑内阿片肽含量的变化。

Results CCK possesses the ability to suppress the convulsant effects of convulsants. CCK8 is able to reduce the neural damage caused and delay the neural aging. CCK antagonists play an important role in human pain transduction.

结果 CCK作为神经递质能够拮抗致痫剂的致痫作用；CCK8还能够对抗神经元的手术和化学损伤以及延缓神经元老化；CCK在痛觉传导过程中起到了重要的整合作用。

MethodsⅠMaximal electroshock seizure was adopted to analyse the relative of dose and effect, relative of time and effect, including maximal efficacy and potency of these five extractives in mice given by ig administration.ⅡMetrazol seizure test was used to compare seizure latency, anticonvulsant rate and mortality of mice with every extractives.ⅢPharmacodynamic parameters of five alcoholic extractives were assayed by means of Pharmacological Effective Method.ⅣUsing the model of seizure rats induced by penicillin localized injected in cortex,we studied the effect of extractives on seizure latency, frequency of epileptiform discharge, highest wave of hippocampus EEG(Recoded by RM6240C multichannel physiological signal collection and analysis recorde), the changes of convulsant behaviors and the latency of seizure.

方法①采用最大电休克惊厥模型，分析灌胃小鼠各药的量效和时效关系，比较其效价强度和效能；②采用戊四唑惊厥模型，比较ig小鼠各药的惊厥潜伏期、抗惊厥率和死亡率；③采用药效法，运用数学模式及参数来模拟各药在体内的药效动力学过程；④制备大鼠皮层定位注射青霉素点燃模型，采用RM6240C型多道生理信号采集处理系统记录脑电图，比较ig各药对痫性发作潜伏期及发作程度、痫性放电潜伏期、痫波发放频率及最高波幅的影响；⑤采用HPLC法测定海马区癫痫相关递质的含量，比较各药对Glu、Asp、Gly、GABA的影响。

Animals were randomly divided into four group: group 1, as control (n=8), without induction of epilepsy; group 2 (n=8), 30 min after intrahippocampal injection of benzylpenicillin; group 3 (n=8), 60min after intrahippocampal injection of benzylpenicillin; group 4 (n=10), 60 min after intrahippocampal injection of benzylpenicillin with EA treatment in the last 30 min (P60 +EA); At the end of each treatment, EEG of each animal was recorded and its RP was analyzed.

我室以往工作表明，针刺具有抗痫作用，而MT也具有抗痫作用，且有资料表明，癫痫患者内源性MT水平发生变化，因此，我们又运用毛细管电泳技术结合电化学检测法，对青霉素所致痫样发作的大鼠在癫痫发作期间和电针抗痫时松果体、海马和血浆内的MT水平进行了测定。

The control group was teated with antiepilepsy according to the therapeutic principle of stroke.

对照组按脑卒中治疗原则及抗痫治疗，治疗组在常规治疗的基础上加用含镁极化液。

Recently, along with the related research on calcium channels, the function of voltage-dependent calcium channel in epileptics gradually draws researchers' attention, and then calcium antag...

近年来，随着对钙通道的研究的深入，尤其是电压依赖性钙通道在痫性活动中的作用越来越受到重视，钙拮抗剂也迅速成为抗癫痫药物的一个重要组成部分。

These results suggest that the prescription reciped based on the theory of the correlation between spleen-stomach and mentality can effectively hold back the epileptogenesis. The antiepileptic mechanism of the prescription may relate with reducing the release of monoamines; regulating the level of cAMP and cGMP and diminishing gene and protein expression of c-fos、c-jun.

本文研究结果提示，根据脾胃与神志相关理论，以调理脾胃为主旨组成的复方能有效阻抗PTZ点燃大鼠EP发作；其抗痫机理可能与减少单胺类神经递质的释放、调节cAMP、cGMP水平，进而削弱c-fos、c-jun基因及蛋白的表达有关。

The model group, TAD group and western medicine group were all injected with 35 mg/kg pentylenetetrazol by intraperitoneal injection, once a day for 4 weeks to induce epileptic models.

目的：动态观察具有调理脾胃气机作用的草果知母汤在阻抗癫痫形成中对大鼠大脑海马区凋亡调控因子p53蛋白表达的影响，分析其抗痫作用的分子生物学途径。

To discuss the dynamic expression of NF-kB mRNA, IL-6 mRNA in the hippocampal zone of chronic epilepsy rats caused by Pentylenetetrazol, and the anti-epileptic mechanism of Dexamethasome Wistar rats were randomly divided into three groups: the control group, non-medical group and medical group.

目的 探讨戊四氮慢性致痫大鼠海马区NF-kB mRNA、IL-6 mRNA动态表达及地塞米松的抗痫机制。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。