抗病毒的

Specific biological activities of indole alkaloids presented here include: cytotoxicity, antiviral, antiparasitic, antiinflammatory, serotonin antagonism, Ca-releasing, calmodulin antagonism, and other pharmacological activities.

在这里，我们展示了吲哚类生物碱的独特生物活性，包括：细胞毒、抗病毒、抗寄生虫、抗炎、拮抗5-羟色胺、钙释放、拮抗钙调蛋白及其他药理活性。

ObjectivesThe objective of this research topic is to investigate the effective compound of Giant knotweed Rhizome against the anti-Friend Murine Acquired Immunodefiency Syndrome (Friend-MAIDS) of reservatrol in vivo and discuss its anti-viral mechanism.

目的 本课题研究的目的是通过体内实验，研究中药虎杖有效成分白藜芦醇的抗Friend型鼠艾滋病作用，并初步探讨其抗病毒作用的机理，为开发传统中药有效抗病毒单体，并应用于临床提供可靠的实验数据。

Methods: Bacterial infection mouse models were established by the peritoneal injection of Staphylococcus aureus and viral pneumonia mouse models by nose drip of influenza virus; Fever rabbit models were produced by vein injection of indotoxin. YZHH was used to treat these animal models.

采用小鼠腹腔注谢金黄色葡萄球菌的方法观察一枝黄花抗感颗粒的体内抗菌作用；采取流感病毒滴鼻致小鼠流感病毒性肺炎模型观察其对小鼠的抗病毒作用；采用家兔耳缘静脉注射内毒素致热的方法，观察其解热作用。

Abstract］ objective: to observe the antibacterial, antivirus and antipyretic functions of yi-zhi-huang-hua-kang-gan granules. methods: bacterial infection mouse models were established by the peritoneal injection of staphylococcus aureus and viral pneumonia mouse models by nose drip of influenza virus; fever rabbit models were produced by vein injection of indotoxin.

采用小鼠腹腔注谢金黄色葡萄球菌的方法观察一枝黄花抗感颗粒的体内抗菌作用；采取流感病毒滴鼻致小鼠流感病毒性肺炎模型观察其对小鼠的抗病毒作用；采用家兔耳缘静脉注射内毒素致热的方法，观察其解热作用。

For most viruses,there is aneed for antimicrobials that target unique viral molecular properties.Acycloviris one such drug.It is activated into ahuman herpesvirusDNA polymerase inhibitor exclusively by HHV kinases and,thus,does not suppress other viruses.Here,we show that ACV suppresses HIV-1in HHV-coinfected human tissues,but not in HHV-free tissue or cell cultures.However,addition of HHV-6-infected cells renders these cultures sensitive to anti-HIV ACV activity.We hypothesized that such HIV suppression requires ACV phosphorylation by HHV kinases.Indeed,an ACV monophosphorylated prodrug bypasses the HHV requirement for HIV suppression.Furthermore,phosphorylated ACV directly inhibits HIV-1reverse transcriptase,terminating DNA chain elongation,and can trap RT at the termination site.These data suggest that ACV anti-HIV-1activity may contribute to the response of HIV/HHV-coinfected patients to ACV treatment and could guide strategies for the development of new HIV-1RT inhibitors.

对大多数病毒而言，都需要有针对其分子特性的靶向杀毒剂阿昔洛韦就是这样一种靶向药物在人疱疹病毒酶的特定作用下，阿昔洛韦被激活成为人疱疹病毒DNA聚合酶抑制剂，因此不能再抑制其它的病毒我们的研究发现阿昔洛韦在共感染人疱疹病毒的组织中可以抑制HIV-1，但在无人疱疹病毒感染的组织或细胞中无此作用然而，加入人疱疹病毒-6感染的细胞却使得其对抗HIV的阿昔洛韦变得敏感我们推测这种抑制作用依赖于人疱疹病毒酶导致的阿昔洛韦磷酸化实际上，单磷酸化的阿昔洛韦前体药物无需人疱疹病毒的参与即可抑制HIV此外，磷酸化的阿昔洛韦能直接抑制HIV-1逆转录酶，将其阻止在终止位点，从而终止DNA链的延长这些结果提示阿昔洛韦的抗HIV-1活性决定了艾滋病病毒/人疱疹病毒共感染的患者对阿昔洛韦的治疗反应，也有助于开发新的HIV-1逆转录酶抑制剂

Each type evokes antibodies which protect against the homologous , but not heterologous virus.

每一种抗原型都能产生抗同种病毒的抗体，但对异种病毒则不能。

Methods By using Vero cell as the host cells and with acyclovir as the positive control, anti-HSV-1 activity of the extract was observed and determined with cytopathic effect assay and plaque reduction assay. Initial studies on antiviral mechanism included three aspects: virucidal assay, attachment assay and penetration assay.

以Vero细胞为宿主细胞，阿昔洛韦为阳性对照药物，通过观察细胞病变效应与空斑减数实验测定川楝子提取物抗HSV-1活性，计算其IC50与治疗指数，并从药物对病毒的直接灭活作用、对病毒吸附的影响及对病毒穿膜的影响三个方面初探川楝子提取物抗HSV-1活性的机理。

Expression of a viral OTU domain-containing protein antagonizes the antiviral effects of ISG15 and enhances susceptibility to Sindbis virus infection in vivo.

表达的一种病毒活otu域含蛋白拮抗抗病毒药物的影响isg15并提升易感性辛德比斯病毒感染的体内。

According to experiments, RDQ produced marked effect on inhibiting bacterium and virus, enhancing immune power, detoxicating and inhibiting mediators of inflammation.

复方中药制剂热毒清注射液在临床上对细菌和病毒引起的急性感染性疾病疗效显著，通过实验研究，RDQ在抑菌抗病毒、增强机体免疫力、抗内毒素和抑制炎症介质等方面发挥作用。

Heat-clearing and detoxicating, supplementing Qi and nourishing Yin, removing toxic material phlegm blockd and blood stasis are important treatment principal of VP. Qingyang decoction may reduce the immunopathological injury caused by virus through regulating the expressing level of cytokine and balancing the immune state of the body. It's possible the one mechanism for Qingyang decoction to anti-influenza virus by improving the ability of the organism.

清养汤通过抑制流感病毒感染小鼠机体内炎症相关因子的水平，调节病毒感染小鼠的免疫细胞因子水平，进而整体调节机体的免疫功能，提高机体的抗病毒能力，减轻炎性损伤的作用，可能是清养汤抗流感病毒性肺炎的作用机制之一。

The basic concept of FOP can be summarized as to further optimize effective prescription according to the standard of curative effects and with the aid of modern science and technology and theories of traditional Chinese medicine.

其基本内涵可概括为：以确有疗效的中药复方为研究对象，以现代科学技术和传统中医药理论为技术支持，以该复方所治病证的药效响应为评价标准，以优化重组疗效更优的新复方为研究目的。

Ever since our world has been a world, native forests have been indiscriminately exploited by man.

自从我们的世界一直是世界原生森林被任意剥削人。