抗生的

The bacteriostatic effects, action mechanisms and antimicrobial spectrum of the strains were tested. After 5 days of culture, a bacteriostatic belt of 6.9-9.67 mm in width was observed on the culture plate, and the inhibitory activity maintained for 10 d. Prefiltration fermentation of the strains P1 and P5 could significantly inhibit conidial germination of the pathogen, with inhibitive rate ranging from 97.51% to 98.12%. The action might be realized by inducing hyphal deformity, bioplasm concentration, conidial germination inhibition and distorting germ tubes of conidia.

通过对其抑菌效果、机制和抗真菌谱进行测定，结果表明，P1、P5和葡萄灰霉病菌对峙培养5 d后，均产生明显的抑菌带，抑菌带宽度为6.90～9.67 mm，培养10 d后，仍然保持稳定的抑菌效果；P1、P5的发酵原液对葡萄灰霉病菌孢子萌发具有显著的抑制作用，抑制率为97.51%～98.12%；P1、P5对病菌的作用机制表现为使病菌菌丝畸形、原生质浓缩、菌丝断裂、抑制病菌分生孢子的萌发、导致孢子芽管扭曲。

Some experiments with different annealing temperature (800℃?900℃?1000℃),different deformation and different secondary annealing temperature(500℃?600℃) were carried out on the invar alloy.The microstructure and mechanical properties were observed and tested respectively,and the influence of the process parameters on them was analyzed.

针对实际生产中Invar合金抗跌落性能差的问题，对Invar合金试样进行了不同温度(80 0℃、90 0℃、10 0 0℃)的退火、不同变形量的冷变形及不同温度(5 0 0℃、6 0 0℃)的二次退火试验，并进行了显微组织观察和力学性能试验，分析各种工艺参数对Invar合金的组织和性能的影响。

For the pursuit of the sunshine and the achievement of the survival will, it always grows tortuously and persistently across the earth, however heavy the upper stone or however narrow the crack between the stones. Its stem drills under the earth and its bud sticks out of the land. The strength is irresistible, which overturns the blocking stone. How powerful the seed.

他为着向往阳光，为着达成它的生之意志，不管上面的石块如何重，石块与石块之间如何狭，它必定要曲曲折折地，但是顽强不屈地透到地面上来，它的根往土壤钻，它的芽往地面挺，这是— 1 种不可抗的力，阻止它的石块，结果也被它掀翻，一粒种子的力量的大如此。

The presented papers in the XXIX IULTCS Congress and 103rd ALCA Annual Meeting were reviewed The papers covered the following field tanning mechanism treatment of tannery effluents environmental regulation biodegradation of leather and leather chemicals utilization of leather waste clean technology of leather making preservation of raw hides and microbial protection of leather novel leather process and materials physical and mechanical properties of leather new analytical and detecting equipments and method .

本次会议论文主要涉及：皮革鞣制机理的研究，皮革行业的污染治理，皮革行业环境保护政策及动向，皮革及其化学品的生物降解，胶原及制革废弃物的资源化利用，制革清洁生产技术，生皮的清洁化防腐保存和皮革的抗菌防霉，制革新工艺和新材料，皮革的物理机械性能及新的皮革分析检测设备和方法等。

The presented papers in the XXIX IULTCS Congress and ALCA Annual Meeting were reviewed The papers covered the following field tanning mechanism treatment of tannery effluents environmental regulation biodegradation of leather and leather chemicals utilization of leather waste clean technology of leather making preservation of raw hides and microbial protection of leather novel leather process and materials physical and mechanical properties of leather new analytical and detecting equipments and method .

本次会议论文主要涉及：皮革鞣制机理的研究，皮革行业的污染治理，皮革行业环境保护政策及动向，皮革及其化学品的生物降解，胶原及制革废弃物的资源化利用，制革清洁生产技术，生皮的清洁化防腐保存和皮革的抗菌防霉，制革新工艺和新材料，皮革的物理机械性能及新的皮革分析检测设备和方法等。

Majority of acute leukemias in infant, either acute lymphoblastic leukemia or acute myeloblastic leukemia, posses a chromosomal translocation affecting the 11q23 chromosome region which specifically inoles the mixed-lineage leukemia gene.1-3 Most pediatric leukemias with MLL rearrangement clearly hae a remarkably short latency.1,4 MLL gene rearrangement is also associated with secondary leukemias of patients preiously treated with the topoisomerase II inhibitors.4 The latency of these secondary leukemias is similarly ery short.4 Of note, the concordance rate of leukemia with MLL rearrangement in infant monozygotic twins approximates to 100%,1,4 and identical breakpoint in the MLL gene was shared in these pairs of identical twin infants with concordant ALL.1,4 Moreoer, the unique and clonotypic MLL fusion gene was detectable in neonatal blood spots for Guthrie cards from non-twined indiiduals who subsequently deeloped ALL.1,4 These obserations indicate not only that MLL fusion is generated in utero but also that MLL fusion proteins could be capable of inducing leukemic transformation with few, if any, secondary mutations.2,3,4 Greaes et al speculate that an MLL fusion protein somehow promotes rapid transition to full-blown disease in patients ia ery rapid clonal expansion, genetic instability, or inhibition of DNA damage repair.4 In general, for clonal expansion of malignancies, tumor cells often hae acquired strategies that escape immune sureillance of the hosts.5,6 Immune escape mechanisms also contribute to the failure of graft-ersus-leukemia effect after allogeneic hematopoietic stem cell transplantation.7 Therefore, leukemia cells could acquire some immune escape mechanisms during leukemogenesis.

绪论 绝大多数的婴儿白血病，不管是急性淋巴性白血病或是急性骨髓性白血病，在染色体11q23部位有染色体易位的情况；这个部位的染色体易位牵连了混合谱系白血病基因。大多数具有MLL基因重排的儿童白血病潜伏期明显短很多。MLL基因重排也和经拓扑异构酶II抑制剂治疗后的继发性白血病有关。这些继发性白血病的潜伏期类似地都非常的短。很重要的是，单卵双胞胎婴儿同时患有或同时免于MLL基因重排阳性的白血病的一致性接近100%；并且同样患有ALL的同卵双胞胎的MLL基因的断裂点是一致的。而且，这种独特的克隆特异性的MLL融合基因能够从那些得ALL的非双生个体出生时的血斑标本中检测到。这些发现表明MLL融合基因产生在胎儿还在子宫的是后，而且MLL融合蛋白能过和其他的基因突变一起诱导白血病的产生。Greaes 等推测MLL融合蛋白在某种情况下同过快速克隆增殖，遗传的不稳定性或是DNA损伤修复的抑制促使疾病迅速地全面爆发。恶性肿瘤细胞的克隆增殖通常已经获得了逃避机体免疫监视的能力。免疫逃避机制也归因于异体外周血干细胞移植后移植物抗白血病作用的失效。所以，白血病细胞在白血病的产生过程中可能获得了某些免疫逃脱机制。

The team developed a siRNA product that specifically blocks the transcription of the gene that codes for IL-8, thereby blocking production of this protein, and encases it in a liposome delivery system. In mouse studies, this product showed activity against 2 ovarian cancer cell lines, both when used alone and when used in combination with docetaxel. In addition, the mouse studies revealed that the product was decreasing tumor growth through anti-angiogenic mechanisms — the treated tumors showed a lower microvessel density, the researchers report. This product was \"highly effective in our preclinical studies and may merit clinical development,\" they write. However, they also caution that the cell lines used to create the mouse models might not accurately reflect the heterogeneity seen in human tumors.

该团队发展一种siRNA產品，特别阻断IL-8的基因转译密码，因此阻断此一蛋白质之產生，且将它包入一个微脂粒传递系统；在老鼠研究中，不论单独使用或者和docetaxel併用，此產品显示对两种卵巢癌细胞线有活性；此外，老鼠研究发现此產品可透过抗血管新生机转减少肿瘤生长—报告指出，治疗的肿瘤显示较少的微血管密度，此產品在我们的临床前研究中相当有效，值得临床发展；不过，他们也表示，所用的老鼠研究中的细胞线可能无法精準反应人类肿瘤的异质性。

In this dissertation, construction methods of long span arch bridges are reviewed firstly, and the lifting process of Shengmi Bridge's arch ribs is illuminated in detail. In succession, the status of study of wind-resistance in long span bridge construction is presented, and then the necessity of work of this dissertation is brought forward.

本文首先回顾了大跨度拱桥的施工方法，详细说明了生米大桥主拱肋吊装的施工过程，接着介绍了目前大跨度桥梁施工期间抗风研究的现状，提出了进行本文工作的必要性。

Patients with mild or moderate hepatic failure or intestinal fat-malabsorption syndromes, as well as patients who are taking anticonulsant medications, glucocorticoids, or other drugs that actiate steroid and xenobiotic receptor, require higher doses of itamin D (Table 3).7,88 Exposure to sunlight or ultraiolet B radiation from a tanning bed or other ultraiolet B–emitting deice is also effectie.

有几类病人需要更高剂量的维生素D（表3）[7，88]，如轻中度肝功能不全、肠脂肪吸收不良综合征的病人，服用抗惊厥类、糖皮质激素类以及可激活类固醇和异生质受体类药物的病人。病人通过适当的日光照射、躺在晒黑床上紫外线B照射或其他紫外线B放射仪治疗，也能取得增加维生素D用量的效果。

Methods Explore the optimal concentration of phurbol-12-myristate-acetate and calcium ionophore (A23817) inducing time, and optimal concentration of biotinyl sheep anti mouce IgG (bio-SAM-IgG) and horse radish peroxidasestreptavidin. The CD4(superscript +) cell enriched from peripheral blood mononuclear cells using solid phase anti-CDs monoclonal antibodies were induced by PMA and A23817 under influence of monensin and harvested in vary hours.

从健康人外周血单个核细胞中富集CD4细胞，加入莫能霉素，用不同浓度的佛波醇酯和钙离子载体(A23817)诱导CD4细胞不同时间，比较其胞内表达白细胞介素－2(IL-2)/白细胞介素－4(IL-4)的细胞百分率，确定最适诱生条件；用不同稀释度的IL-2McAb、IL-4McAb、不同浓度的生物素化羊抗鼠IgG(bio-SAM IgG)和辣根过氧化物酶标记的链霉亲和素作棋盘配比试验，确认McAb、bio-SAM IgG和HRP-SA的最适浓度，根据上述结果建立了检测细胞内细胞因子的BSA-ICC法。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。