抗毒性

Sodium arsenite can induce oxidative stress,and antioxidants can antagonize the cytotoxicity of arsenic.

亚砷酸钠可引起细胞内氧化应激，抗氧化物可一定程度拮抗砷的细胞毒性作用。

Methanol extracts of two kinds of formicary were investigated for their free radical scavenging activities, total phenolic content, reduction power and antimicrobial activities.

对两种不同的蚂蚁窝进行甲醇提取，并对提取物进行了急性毒性、抗自由基，酚含量、还原能力和抗菌活性的检测。

Pokeweed antiviral protein belongs to Ribosome-inactive Proteins. PAP has potent antiviral activity against many plant virus. pT1 was used as the template to amplify the deleted mutant PAP gene (N-deleted and N-,C-deIeted) by PCR and then the two genes were cloned into expression vector. Different IPTG-inducible expression vector containing different deleted mutant PAP gene was constructed and transferred into E.coli strain BL21 (DE3)-plysS.

美洲商陆抗病毒蛋白是一类能很好的抑制植物病毒的蛋白，很早就有报道低剂量的商陆叶片粗粉末就能明显的抑制TMV在菜豆叶片上局部枯斑的形成，PAP缓释剂也已用于病毒病的防治工作，但美洲商陆抗病毒蛋白属于核糖体失活蛋白，它对生长的细胞会有一定的毒性。

Results The HSV infected cell culture system we established stable for utilization: Cellular damage and abnormal growth were not found in Hep-2 cells cultured with SDS at 10%×2-3×10-1(1.25mg/ml).The Hep-2 cells mainly became swelling and falling off and few of them formed syncytium after infected by HSV. The CPE occurred time and scale of CPE depended on multiplicity of infectionof HSV.SDS inhibited HSV yield with the manner of dosage dependent.

在 HSV 感染的 Hep-2 细胞培养系统中分别观察 SDS 对 Hep-2 细胞的毒性作用、SDS 对 HSV 致 Hep-2 细胞病变的影响、SDS 对 HSV 空斑形成的阻断效应、四唑盐(diphenyl tretrazolium bromide，MTT)比色试验检测不同浓度 SDS 抗 HSV 效应、以及 SDS 和阿昔洛韦(Aciclovir， ACV)抗HSV 效应的比较。

In addition ,GM1 has anti-excitotoxicity, anti-oxidation and vasodilation properties.

除此之外，它还具有抗兴奋性毒性、抗氧化、扩血管等作用。

objective: to achieve the soluble expression of mn-sod gene in e.coli and assay the enzyme activity of the expressed product. methods: the coding region of superoxide dismutase was amplified using pcr method from the e.coli genome. the pcr product was cloned into puc19-t vector and sequenced.in addition,the cloned coding region of mn-sod was inserted into the expression vector pet-28a to form the recombinant plasmid pet-28a-mn-sod and was then transformed into e.coli bl21 for expression.

超氧化物歧化酶(superoxide dismutase，sod)是细胞体内歧化超氧阴离子自由基(o-2)的一个抗氧化酶，按其结合的金属性离子根据其中金属辅基的不同可分为4类：cu/zn-sod、mn-sod、fe-sod和ni-sod，它们通过催化超氧阴离子自由基0-2发生歧化反应，达到清除o-2的效果，具有防御氧毒性、增强机体抗辐射损伤能力、防衰老以及治疗某些肿瘤、炎症、自身免疫疾病等功效，广受国内外科研工作者的关注和重视[1]。

Adverse events were similar in both groups, and the incidence of symptomatic heart failure was lower than expected among those in the trastuzumab group (less than 2%), which supports "the accumulating evidence that trastuzumab can be given concurrently with anthracyclines with a low frequency of symptomatic cardiac dysfunction, provided that low cumulative doses or less cardiotoxic anthracyclines are used, and careful cardiac monitoring is done," the authors said.

作者表示，两组的不良事件发生率相似，曲妥珠单抗组症状性心力衰竭发生率低于预期(低于2%)，这支持如下观点，&越来越多的证据表明，如果应用的累积剂量较低或心毒性蒽环类药物较少且实施严密心脏监测，那么曲妥珠单抗与蒽环类药物就能够联用且所致的症状性心功能不全发生率较低。&

The method builds model of lung cancer of small rat Lewis, those who evaluate content of content of capsule of antler glossy ganoderma resist tumor and the influence that resist oxidation and noxiousness of platinic to arranging kidney, compare content of content of capsule of antler glossy ganoderma with MTT law the cellular poison of individual plant of cell of tumour of person of different to 10 kinds outside body type is active.

方法建立小鼠Lewis肺癌模型，评价鹿角灵芝胶囊内容物的抗肿瘤和抗氧化功能及对顺铂肾毒性的影响，并用MTT法比较鹿角灵芝胶囊内容物在体外对10种不同类型人肿瘤细胞株的细胞毒活性。

In this paper, the stable Au complexes are classified according to the coordination atoms and their characteristic structure. The recent development of the researches on the antitumor activity of Au complexes including the structure-activity relationship, biological targets and the mechanisms of action are reviewed. The structure of the coordination ligand and the leaving group have great impact on the in vitro cytotoxicity of the Au complex. Many physical and biological methods are introduced to study the interaction between the Au complexes and the suspected bio-target, such as DNA, protein, mitochondrion, thio-containing biomolecules, etc. The interaction modes (intercalating, electrostatic interaction, covalent bonding, etc.) are focused to illustrate the reason for the antitumor activity of Au complexes.

本文按配位原子的不同总结了稳定三价金配合物的结构特征，按其生物活性的构效关系、生物靶点和作用机制综述了三价金配合物抗肿瘤活性研究的最新成果：配体的结构特点以及离去基团对三价金配合物的体外细胞毒性影响较大；介绍了用于检测三价金配合物与可能的生物靶分子之间的相互作用的多种物理和生物学方法，重点关注了相互作用的模式，如嵌入/静电吸引/共价结合等，并解释了三价金配合物抗肿瘤活性的原因。

In this paper, the stable Au complexes are classified according to the coordination atoms and their structural characteristics. The recent development of the researches on the antitumor activity of Au complexes including the structure-activity relationships, biological targets and the mechanisms of action are reviewed. The structure of the coordination ligand and the leaving group have great impact on the in vitro cytotoxicity of the Au complex. Many physical and biological methods are introduced to study the interaction between the Au complexe and the suspected bio-target, such as DNA, protein, mitochondrion, thio-containing biomolecules, etc. The interaction modes (intercalating, electrostatic interaction, covalent bonding, etc.) are focused to illustrate the reason for the antitumor activity of Au complexes.

本文按配位原子的不同总结了稳定三价金配合物的结构特征，按其生物活性的构效关系、生物靶点和作用机制综述了三价金配合物抗肿瘤活性研究的最新成果：配体的结构特点以及离去基团对三价金配合物的体外细胞毒性影响较大；介绍了用于检测三价金配合物与可能的生物靶分子之间相互作用的多种物理和生物学方法，重点关注了相互作用的模式，如嵌入/静电吸引/共价结合等，并解释了三价金配合物抗肿瘤活性的原因。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。