抗毒性

The α-methylenecyclopentanone, as an isostere of α-methylene-γ-lactone, within the molecules of diterpenes may be as effective as α-methylene-γ-lactone towards various sulfhydry-containing enzymes.

然而，由于α-亚甲基-γ-丁内酯结构内在的化学活性太强，尽管这些合成的小分子化合物仍具有抗癌或抗炎活性，但并没有达到降低毒性，提高选择性的目的。

Of the unmodified mAbs with a known isotype, 77 (95%) were IgG, whereas 4 (5%) were IgM, which function primarily through CDC.

在已知的同种型单抗中，77种(95%)是IgG ，4种(5%)是 IgM，主要通过补体介导的细胞毒性起作用。

The spider Latrodectus tredecimguttantus is one of the most venomous spiders in the world.

间斑寇蛛Latrodectus tredecimguttatus是世界上毒性最强的蜘蛛之一，其毒液中含有许多大分子物质，可用于制备抗血清。

Result:(1)Tau prevented neurons against Mn toxicity of low and middle concentrations. The ideal conditions can reach upon 4. 5 mM Tau added just, nearly no apoptosis cells could be detected.(2)The percentages of apoptosis intogether were lower than those in Mn just , being concentration-dependent relations with Taurine levels.(3)Mn induced DNA damage of neurons with dose-depedent, The higher of Mn concentration, the lengther of the comet tail and the higher percent comet-like cells. Tau incubated could weaken significantly the lesions of Mn towards DNA on the degree.

结果：(1)牛磺酸对中低剂量锰的毒性有一定的拮抗作用，单独加入牛磺酸效果最好剂量是4.5mM，视野下几乎不见凋亡细胞；(2)牛磺酸干预后培养神经细胞凋亡率低于相同剂量的单纯锰培养细胞组，且与牛磺酸浓度呈剂量依赖性；(3)锰引起培养神经细胞DNA损伤，表现在彗星尾长增加，彗星样细胞百分率增加；加入牛磺酸干预后，可明显改善锰造成的培养神经细胞DNA损伤。

Intermittent regiment with regular dosage at three times aweek can relieve or avoid severe hepatotoxicity and aliˉmentary upset and glutathin combined may reduce recovery time of hepatic impairment.

常规剂量每周3次间歇抗结核化疗，可以避免或缓解常规化疗的严重肝脏毒性和消化道症状，联合谷胱甘肽可缩短肝功能恢复时间。

NB can make liver, brain, spleen and nephridial tissue pathology damage, to refrain theactivity of liver mixed function oxidase, induce oxidative stress, effect tissue enzymatic activity,destroy organism antioxygen defence system and function of clean up free radical, to cause proteinoxidation damage, to educe toxic action.

综上所述，NB可以造成肝、脑、脾、肾组织的病理学损伤，抑制肝内混合功能氧化酶的活性，诱导氧化应激，影响组织酶活性，破坏机体抗氧化防御系统及清除自由基功能，引起机体蛋白质氧化损伤，进而发挥其毒性作用。

These growth factors have the effects of neurogenesis, angiogenesis, neurotrophy, inhibitory excitoxity induced by glutamate and NMDA, and anti-oxidative, by these ways they can prevent neural cells from death.

这些生长因数均有保护神经细胞避免因为脑损伤而造成的死亡，其作用有神经生长性、血管生长性、神经滋养性、抑制麸氨酸盐与NMDA所引发的兴奋性毒性及抗氧化作用，但是这些仅限於动物模式，应用於临床还有一段艰辛的历程。

Results: 850 irrational prescriptions were identified (3.89%), mainly manifested in nonstandardized handwriting, discrepancies between pharmaceutical indication and diagnosis, repeated medication, no indication for the use of antimicrobial drugs, improper dosage, increased toxicity and pharmacological antagonism.

结果：不合理处方850张（占3.89%），主要表现在书写不规范、药品适应症与诊断不符、重复用药、无指征使用抗菌药物、用法用量不当、毒性增加、药理拮抗等方面。

zinc could inhibit the luminescence rate of photoluminescent bacteria and antagonize MeHg toxicity in certain dose and time.

Zn可以抑制MeHg对发光杆菌发光率的影响，拮抗甲基汞的毒性。

Genes for resistance to leaf rust in twenty-four important wheat cultivars from six wheat breeding institutes or companies were analyzed using fourteen isolates of Puccinia triticina.

选用14个具有不同毒性基因组合的叶锈菌系，推导分析了来自山西省6个育种单位和种子部门的24个重要小麦品种所携带的抗叶锈病基因状况。

I am accused of being overreligious," she said in her quiet, frank manner,"but that does not prevent me thinking the children very cruel who obstinately commit such suicide.""

客人们在卡罗利娜·埃凯家里，举止就文雅一些，因为卡罗利娜的母亲治家很严厉。

Designed by French fashion house Herm è s, this elegant uniform was manufactured in our home, Hong Kong, and was the first without a hat.

由著名品牌 Herm è s 设计，这件高贵的制服是香港本土制造，是我们第一套不配帽子的制服。