抗毒剂

The invention relates to the isolation and preparation of an active fraction from plant Cuminum cyminum, its further purification and standardization as chemically defined entity with their intended use as drug bioavailability enhancer for the drugs belonging to therapeutic categories such as antimicrobial, antifungal, anti-viral, antitubercular, antileprosy, anti-inflammatory, antiarthritic, cardiovascular, antihistaminics, respiratory distress relieving drugs, immunosuppressants, anti-ulcerogenic, anti-cancer, CNS drugs, corticosteroids, nutraceuticals in compositions to be administered orally/parenterally, topically, inhalations, rectally, vaginally in human beings and/or veterinary conditions.

本发明涉及植物孜然芹中的一种活性级分的分离和制备，进一步的纯化以及它作为化学确定实体的标准化，和它作为治疗类药物的生物利用率增强剂的特定用途，这类药物包括如抗微生物剂、抗真菌剂、抗病毒剂、抗结核药、抗麻风病药、抗炎药、抗关节炎药、心血管类药、抗组胺药、呼吸窘迫缓解药、免疫抑制剂、抗溃疡药、抗癌药、CNS药、皮质甾类药、营养制品，它们以组合物的形式通过口服/肠胃外，局部，吸入直肠，阴道施用于人和/或兽医学病症中。

The terms mithridatism and mithridate were named after him.

术语抗毒性（通过毒药服用剂量渐增而产生）和万应解毒剂是以他来命名。

For most viruses,there is aneed for antimicrobials that target unique viral molecular properties.Acycloviris one such drug.It is activated into ahuman herpesvirusDNA polymerase inhibitor exclusively by HHV kinases and,thus,does not suppress other viruses.Here,we show that ACV suppresses HIV-1in HHV-coinfected human tissues,but not in HHV-free tissue or cell cultures.However,addition of HHV-6-infected cells renders these cultures sensitive to anti-HIV ACV activity.We hypothesized that such HIV suppression requires ACV phosphorylation by HHV kinases.Indeed,an ACV monophosphorylated prodrug bypasses the HHV requirement for HIV suppression.Furthermore,phosphorylated ACV directly inhibits HIV-1reverse transcriptase,terminating DNA chain elongation,and can trap RT at the termination site.These data suggest that ACV anti-HIV-1activity may contribute to the response of HIV/HHV-coinfected patients to ACV treatment and could guide strategies for the development of new HIV-1RT inhibitors.

对大多数病毒而言，都需要有针对其分子特性的靶向杀毒剂阿昔洛韦就是这样一种靶向药物在人疱疹病毒酶的特定作用下，阿昔洛韦被激活成为人疱疹病毒DNA聚合酶抑制剂，因此不能再抑制其它的病毒我们的研究发现阿昔洛韦在共感染人疱疹病毒的组织中可以抑制HIV-1，但在无人疱疹病毒感染的组织或细胞中无此作用然而，加入人疱疹病毒-6感染的细胞却使得其对抗HIV的阿昔洛韦变得敏感我们推测这种抑制作用依赖于人疱疹病毒酶导致的阿昔洛韦磷酸化实际上，单磷酸化的阿昔洛韦前体药物无需人疱疹病毒的参与即可抑制HIV此外，磷酸化的阿昔洛韦能直接抑制HIV-1逆转录酶，将其阻止在终止位点，从而终止DNA链的延长这些结果提示阿昔洛韦的抗HIV-1活性决定了艾滋病病毒/人疱疹病毒共感染的患者对阿昔洛韦的治疗反应，也有助于开发新的HIV-1逆转录酶抑制剂

The study is possible for experimenters to offer theoretic direction while developing new type quercetin metal complex with higher activity antioxidants. At the same time, the study offer theoretical foundation that quercetin can be used as a kind of antidote for superfluous meatal ion in body.

本文通过对槲皮素金属配合物的合成、生物活性及其量子化学的较深入地研究，为进一步寻找高效、低毒的抗氧化性槲皮素配合物提供了一定的参考价值，同时为槲皮素可作为体内过多金属离子的解毒剂提供了依据。

A process for partial conversion and low-temp transform of CO in the synthetic ammonia plant where coal is used to generate gas features that the Fe-Mo catalyst for partial conversion of CO, anti-poisoning agent and Co-Mo catalyst for low-temp conversion are used and the temp of semi-water gas is controlled to 200-260 deg.C at entering anti-poisoning layer, and 150-250 deg.C at the segments of said Co-Mo catalyst layer, and lower than 300 deg.C at bed layer to prevent high-temp reversal of sulfurizing reaction and make the catalyst activity optimal. Its advantages are long service life of catalyst, low system resistance, saving energy and convenient operation.

本发明是中小合成氨厂以一种CO部分转化抗毒保护层配低温变换的工艺，涉及煤造气合成氨厂0.6～2.0MPa半水煤气变换工艺流程，该工艺用铁－钼CO部分转化催化剂、抗毒剂，配钴－钼低变催化剂，半水煤气进入部分转化抗毒层温度为200～260℃，进钴－钼低变催化剂各段温度为150～250℃，床层温度控制在300℃以内，避免高温下反硫化反应发生，保护催化剂活性处最佳状态，寿命延长、系统阻力小、节汽、节电，具有比其他变换工艺更好地节能效果，操作方便，有效生产时间长，经济效益显著等特点。

He also mentions antidotes and the use of traditional substances to counter the effects of poisoning.

他也提到了解毒剂和传统抗毒物质的使用。

Mice transplanted with Heps solid tumor and ascites carcinoma were used to study the combination antitumor effect of AA(50,100 mg/kg) and CTX(20 mg/kg).

我国一些传统中药因其较少的不良反应、对机体具有保护和调理作用，成为中西药联合化疗的研究热点。研发新型抗肿瘤增效、减毒剂可能是战胜恶性肿瘤的途径之一［4］。

AIM: To investigate the changes of electrocardiogram, LDH and CK-MB caused by soman, and the therapeutic effects of benthiactzine.

目的：观察神经性毒剂梭曼中毒导致犬心电图和心肌酶的变化及新型抗毒剂宾赛克嗪的解救作用。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。