抗抑制

The resistance to oxidation of synthetical ferulaic acid glycolipide was investigated. The result was shown, apple was dipped in 0.62% ferulaic acid glycolipide, the most inhibitor effectiveness of glucose ferulaic esters and xylose ferulaic ester was shown respectively to be 36.92% after four days and 19.47% after eight days, the fastigium of release ethane was postponed respectively to be six days and four days.

本文测定了合成阿魏酸糖脂的抗氧化性，结果表明用0.62％的阿魏酸糖脂浸泡的苹果，阿魏酸葡糖酯抑制效应在处理后4天最明显，抑制率 36.92%，阿魏酸木糖酯抑制效应在处理后8天最明显，抑制率为 19.47%对于果实的内源乙烯释放，经阿魏酸葡糖酯和阿魏酸木糖酯处理的苹果分别推迟乙烯释放高峰期6天和4天。

An antibody binding to IGF-IR and inhibiting the binding of IGF-I and IGF-II to IGF-IR which is characterized in that said antibody is a is ofIgG1 isotype, b shows a ratio of IC50 values of inhibition of the binding of IGF-I to IGF-IR to the inhibition of binding of IG-II to IGF-IR of 1:3 to 3:1, c inhibits for at least 80% at a concentration of 5 nM IGF-IR phospohrylation in a cellular phosphorylation assay using 3T3 cells providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0.5% heat inactivated fetal calf serum when compared to such an assay without said antibody, and d shows no IGF-IR stimulating activity measured as IGF-IR phophorylation at a concentration of 10 M in a cellular phosphorylation assay using 3T3 providing 400,000 to 600,000 molecules IGF-IR per cell in a medium containing 0,5% heat inactivated fetal calf serum when compared to such an assay without said antibody has improved properties in antitumor therapy.

一种已经提高了抗肿瘤治疗的特性的抗体，所述抗体结合IGF-IR并且抑制IGF-I和IGF-II与IGF-IR结合，其特征在于所述抗体a是IgG1同种型，b显示其对IGF-I与IGF-IR结合的抑制的IC 50 值与其对IGF-II与IGF-IR结合的抑制的IC 50 值的比率为1∶3-3∶1，c当与没有所述抗体的这种测定比较时，其在5nM的浓度上，在包含0.5％的热灭活胎牛血清的培养基中，使用3T3细胞的细胞磷酸化测定中，抑制至少80％的IGF-IR磷酸化，所述3T3细胞提供400，000-600，000分子IGF-IR/细胞，和d当与没有所述抗体的这种测定相比，在包含0.5％的热灭活胎牛血清的培养基中，使用3T3的细胞磷酸化测定中，其在10μM的浓度上没有显示作为IGF-IR磷酸化所测量的IGF-IR刺激活性，所述3T3提供400，000-600，000分子IGF-IR/细胞。

The expression changes of relating-apoptosis gene proteins (bcl-2, bax) were detected by immunohistochemistry before and after treating with the Agaricus Blazei Murill extract to explore the possible mechanisms of inducing apoptosis for MGC-803 cells in vitro. Results: The Agaricus Blazei Murill extract significantly inhibited the proliferation of gastric cancer cells in vitro and the inhibitive effects were depended on the medicine concentration and treating times. After treating 24 hours on the gastric cancer cells with the morphologic changes of apoptosis with chromatin margination, karyopyknosis, karyorrhexis were found by the light.

结果：(1)通过细胞培养和MTT法，表明长白山姬松茸在体外对MGC-803细胞株有明显的抑制作用，加药组与对照组相比其生长抑制率有显著性差异(P＜0.01)，而且这种抑制作用呈现浓度和时间的依赖性；(2)通过集落形成率的测定结果表明，加药组与对照组相比其集落形成率和集落形成抑制率有明显差异(P＜0.01)，说明长白山姬松茸对MGC-803胃癌细胞株有明显抗增殖作用；(3)光镜观察结果表明，加药组可见细胞脱水浓缩伊红染色增强，胞体缩小，内含高度浓缩的胞核呈深蓝色等典型细胞凋亡形态；经AO／EB荧光染色观察结果表明，当终浓度为1.0mg／ml的姬松茸提取物作用于MGC-803胃癌细胞24h后，其凋亡率和破膜率与自然凋亡率与破膜率相比，均有显著性差异，其凋亡率86.3％(P＜0.001)，破膜率为41.6％(P＜0.01)，说明姬松茸确实有诱导MGC-803胃癌细胞凋亡的作用，同时也有细胞毒作用，但以诱导细胞凋亡为主；(4)免疫组化结果表明，用药前后凋亡相关基因的BCl-2、Bax蛋白均有显著性的改变(P＜0.001)。

By inoculated to tobacco plants, six strains could be re-isolated from the inoculated plants, indicating that they were endophytic bacteria in tobacco. Culture these eight bacteria and Phytophthora parasitica var. nicotianae together, the result showed four endophytic bacteria YN-55, NN-3, YN-4 and YN-10 have the best antagonistic effects.

将这8株内生细菌与烟草黑胫病菌共培，进一步测定拮抗效果结果显示YN-55、NN-3、YN-4和YN-10 4株拮抗效果最好，均在66％以上，并且这4种细菌均对孢子囊的产生有较强的抑制作用，而菌株发酵液对孢子囊的产生的抑制作用不明显。

rutaecarpine pharmacological effects and its related mechanism: rutaecarpine the heart positive inotropic, positive changes in the role and the heart protective effect, which with its promotion of calcitonin gene-related peptide release; rutaecarpine alkali have vasodilative and hypotensive effect, its mechanism mainly related to endothelial cells Ca2 +-NO-cGMP pathways and calcitonin gene-related peptide release; rutaecarpine to relax the anal sphincter, gastrointestinal motility inhibition of stress ulcer and ulcerative colitis have therapeutic effect; rutaecarpine on cerebral ischemia-reperfusion injury has a protective effect, which instead of increasing the concentration of calcitonin gene-related peptide-related; rutaecarpine inhibits platelet aggregation and arterial thrombosis; In addition, rutaecarpine Alkali also anti-inflammatory and analgesic, anti-tumor and other pharmacological effects.

综述了吴茱萸次碱的药理作用及其相关机制：吴茱萸次碱对心脏有正性肌力、正性变时作用和心脏保护作用，这与其促进降钙素基因相关肽释放有关；吴茱萸次碱有扩血管和降压作用，其机制主要涉及内皮细胞Ca2+-NO-cGMP途径和降钙素基因相关肽的释放；吴茱萸次碱能松弛肛门内括约肌，抑制胃肠运动，对应激性溃疡和溃疡性结肠炎也有治疗作用；吴茱萸次碱对脑缺血再灌注损伤有保护作用，这与其增加降钙素基因相关肽浓度有关；吴茱萸次碱能抑制血小板聚集和动脉血栓形成；此外，吴茱萸次碱还有抗炎镇痛、抗肿瘤等药理作用。

Basic on the special mechanism of action of Apo2L/TRAIL, the broad-spectrum antitumor activity and superordinary safety of recombinant human soluble Apo2L/TRAIL in preclinical researches, and the progression of the antitumor study on endogenous antiangiogenic factors, two studies were involved in this paper, including phase I clinical trial of rh-Apo2L and the study on expression of the fusion proteins of human Apo2L and endogenous antiangiogenic factors.

基于Apo2L／TRAIL独特的作用机制、重组人可溶性Apo2L／TRAIL临床前体现出的广谱的抗肿瘤作用和良好的安全性、以及内源性血管生成抑制因子抗肿瘤研究进展，本课题开展了下述两方面的研究：①国产重组人凋亡素2配体(rh-Apo2L)的Ⅰ期临床研究；②人Apo2L／TRAIL与人血管生成抑制因子融合表达的基础研究。

The inhibitory effect of the volatilizable metabolites of two antagonists to P.funerea was analyzed in contrast with the inhibitory rate of the control . Gvirens , with the highest inhibitory rate of 59.7%, had more excellent and stable inhibitory activity and the effect was more relative with the time, but the inhibitory rate of B.firmus was less relative with the time and the inhibitory effect of B.firmus became stable after 72 hours.

两种颉抗菌代谢物中不同成份的抑菌效应试验表明，G.virens产生的多糖、粗脂肪、蛋白质对P.funerea孢子萌发有抑制作用，粗脂肪、蛋白质更明显，其中蛋白质抑制效果较稳定；B.firmus产生的粗脂肪可完全抑制P.funerea的孢子萌发，多糖、蛋白质抑制效果也较稳定，但多糖效果更好。

Injection of rhIL-2 (200,100,50,25,12. 5 ku/kg) can inhibit mouse ear swelling, especially when dosage is 25～50 ku/kg. Injection of rhIL-2 (25 ku/kg) can inhibit rat plantar swelling. The function of mononuclear macrophage system was strengthened by hypodermic injection of rhIL-2( 100 ku/kg) once a day for 9 days. The decrease of mouse delayed-type hypersensitivity reaction induced by cyclophosphamide was extenuated by hypodermic injection of rhIL-2(50 ku/kg) once a day for 6 days. IL-2 has anti-inflammatory effects and immunomodulatory effects when administered in certain dosage.

RhIL-2注射液，剂量为20，10，5，2.5，1.25万u/kg时，对小鼠鼠耳肿胀模型有抑制作用，其中剂量为2.5～5万u/kg时，抑制率最大；剂量为2.5万u/kg时，对大鼠足拓肿胀模型有显著的抑制作用；rhIL-2注射液每日sc用药剂量为10万u/kg，连续给药9d后，可以明显增强小鼠单核吞噬细胞功能；rhIL-2注射液每日sc用药剂量为5万u/kg，连续给药6d后，可明显减轻由免疫抑制剂引起的小鼠迟发性变态反应降低的强度。rhIL-2在一定剂量范围内可以起到抗炎和免疫调节作用。

The paper studied the scavenging active oxygen radicals of brown pigment from chestnut shell. The results showed that the brown pigment had scavenging effects on hydroxyl radical, superoxide anion radical and aliphatic radicals on lipid-peroxidation. In the range of test concentration, the maximum scavenging or inhibition rate of the brown pigment to hydroxyl radical generated by Fenton reaction, superoxide anion radical generated by illuminating riboflavin system and linoleic acid auto-oxidation was 83.0%, 82.1% and 88.5% respectively.

从清除羟基自由基和超氧阴离子自由基、抗脂质过氧化以及还原能力等方面对板栗壳棕色素的抗活性氧自由基进行了试验研究和评价，结果表明：板栗壳棕色素对Fenton反应产生的羟基自由基和光照核黄素产生的超氧阴离子自由基均具有较强清除作用，对脂质过氧化过程中产生的脂自由基和脂过氧化自由基有明显的抑制作用，且在试验浓度范围内，其最大清除率或抑制率分别可达到83.0%、82.1%和88.5%。

Berbamine could inhibit the growth of leukemia cell line NB4. The induction of cell apoptosis may be one of the mechanisms for suppressing the growth of leukemia cell line NB4. Inhibition of Survivin mRNA and upregulation of Caspase 3 protein might be also involved in cell apoptosis.

小檗胺对NB4细胞有增殖抑制作用，诱导细胞凋亡可能是其抗肿瘤作用的重要机制之一，但不是通过作用于NB4细胞特异性融合基因PML/RARα发挥作用的，其抗凋亡的可能分子机制之一是抑制Survivin基因的表达和增加Caspase3的表达。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。