抗抑制

The cytotoxicity of these compounds were valuated by MTT and SRB methods using three cancer cell lines: HL-60, A-549, P-388. Cyclo-shikonin, and cyclo-alkannin have high cytotoxicity against HL-60.The chiral center of side chain has no effect on their activity. 2- 1-(Acetyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (105) has strong inhibition effect on P-388 cells. 2- 1-(isooctyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (108) and 2- 1-(2-furoyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (112) have high inhibition on A-549.Shikonin (1), alkannin (2), and their derivatives have the structural features of a planar chromophores and short side chain. We examined the ability to inhibit the telomerase.

抗肿瘤活性初步筛选测试采用小鼠白血病P-388肿瘤细胞和人肺癌A-549肿瘤细胞进行，结果表明侧链羟基的手性对抗肿瘤活性无明显影响；有数个化合物具有很好的体外抑制活性，特别是化合物2-（1-异辛酰氧基-4-甲基-3-戊烯基）-5，8-二羟基-1，4-萘醌（108）和2-[1-（2-呋喃甲酰氧基）-4-甲基-3-戊烯基]-5，8-二羟基-1，4-萘醌（112）体外显示对人肺癌A-549肿瘤细胞有强效；2-（1-乙酰氧基-4-甲基-3-戊烯基）-5，8-二羟基-1，4-萘醌（105）对小鼠白血病P-388肿瘤细胞有强效；环紫草素和环异紫草素对人白血病HL-60细胞有强烈抑制作用。

In this experiment, we use different kind of solvent to extract Vitaceae plants to test of antioxidae, includes clean DPPH free radical, ferrous ions chelating effects, restrain producing superoxide anion, ferric reducing ability of plasma and anti-liver lipid peroxidation assay.

在利用不同溶媒萃取葡萄科植物评估抗乳癌细胞株MCF-7毒杀试验和抗氧化试验中，其包含清除DPPH自由基、螯合亚铁离子、抑制超氧阴离子之生成、还原三价铁离子能力测定及抗肝脂质过氧化等几项。

In addition to the common effect of supplementing qi, YiQiYangYin Fang has unique clinical application in exercise-induced fatigue disease because of its function of reinforcing yin; YiQiBuShen Fang is used for treating senescence diseases by reason of its function of invigorating kidney.

本课题以中医药理论为指导，依据益气养阴方和益气补肾方的功效与应用，结合目前运动性疲劳和衰老的产生机制等方面的研究进展，采用现代药理学研究方法，观察益气养阴方和益气补肾方对环磷酰胺致小鼠免疫抑制的抵抗作用及对小鼠常压耐缺氧和断头后张口喘气时间的抗应激能力，同时分别采用运动性疲劳大鼠模型和自然衰老大鼠模型进一步探讨益气养阴方抗运动性疲劳机制及益气补肾方抗衰老机制。

The results showed that the fermentation liquid from A44 showed strong inhibitory effect on mycelium growth and on spore germination with tower germination rate against pathogenic funguses Alternarina.alternate .

结果表明A44菌株发酵液对烟草赤星病菌、黄瓜枯萎病菌、西瓜枯萎病菌等病原菌有抗菌活性及抑制孢子萌发作用，且这种作用在A44发酵液稀释了160倍后仍然存在；对峙培养试验表明A44菌对植物病原菌有很强的拮杭作用，拮抗机制主要为营养竞争作用、抗生作用等。

So it was primarily identified as Bacillus subtilis. In the antifungal activity test,the method of sitzkrieg culture, asynchronism culture and hyphal extension inhibition assay of plate were adopted to study the inhibitive effect of the antagonist on Fusarium graminearum, and at the same time,the test conditions were explored.

在拮抗物质抗菌活性测定的研究中，分别采用对峙培养法、异步培养法和杯碟测定法研究枯草芽孢杆菌对小麦赤霉菌的抑制作用，探索抗菌活性测定的条件。

Because the sugar cortical hormone class medicine has very strong anti-function and so on inflammation, anti-allergy, antitoxin, anti-shock, immunity suppression, thus caused it to become the basic unit medical establishment certain doctors' multi-purpose panaceas, no matter any got sick all uses, thus created the sugar cortical hormone class medicine in basic unit abusing.

由于糖皮质激素类药物具有很强的抗炎、抗过敏、抗毒素、抗休克、免疫抑制等作用，因而使其成了基层医疗机构某些医生的万能灵丹妙药，不管什么病都用上，从而造成糖皮质激素类药物在基层的滥用。

because the sugar cortical hormone class medicine has very strong anti-function and so on inflammation, anti-allergy, antitoxin, anti-shock, immunity suppression, thus caused it to become the basic unit medical establishment certain doctors' multi-purpose panaceas, no matter any got sick all uses, thus created the sugar cortical hormone class medicine in basic unit abusing.light creates the nonessential pain and the economic loss for the basic unit patient; heavy endangers the patient life.

由于糖皮质激素类药物具有很强的抗炎、抗过敏、抗毒素、抗休克、免疫抑制等作用，因而使其成了基层医疗机构某些医生的万能灵丹妙药，不管什么病都用上，从而造成糖皮质激素类药物在基层的滥用。轻者给基层患者造成不必要的痛苦和经济损失；重者则危及病人生命。

Rabeprazole belongs to a class of antisecretory compounds ( benzimidazole proton-pump inhibitors) that do not exhibit anticholinergic or histamine H2 -receptor antagonist properties, but suppress gastric acid secretion by inhibiting the gastric H +/K +-ATPase at the secretory surface of the gastric parietal cell.

雷贝拉唑属于抗分泌药物，苯并咪唑的替代品，质子泵抑制剂。不具有抗胆碱活性和组胺h2受体拮抗活性，但是能够胃壁细胞分泌表面的H +/K +-ATPase而抑制胃酸分泌。

Tachyplesin- I , a small antimicrobial peptide from the hemocytes of the horseshoe crab , which has a cyclic anti-parallel 3 -sheet structure held together by two disulfide bonds, permeabilizes both bacterial and artificial lipid membranes at low concentrations.

抗菌肽是一类带正电、多具双亲性的小分子多肽，由于其独特的结构，抗菌肽对多种细菌和癌细胞有强烈的抑制作用，且多数抗菌肽在发挥以上作用时对正常细胞没有破坏作用。

According to correlative literatures, the diagnosis and treatment of bronchiolitis obliterans syndrome in three patients with hematological malignancies after allo-HSCT were analyzed. The function of haematopoiesis re-established successfully. The acute graft versus host disease did not occur in these patients except one patient occurred grade Ⅱ aGVHD, and the chronic graft versus host disease occurred in the 5th, 6th and 6th months after allo-HSCT respectively, but the cGVHD was recrudescent after treatment. The bronchiolitis obliterans syndrome occurred in the 9th, 7th and 11th months after allo-HSCT respectively, and they received the treatment of immunosuppressive, immune human serum globulin, azithromycin and to breathe in β2 receptor agonist and budesonide.

结合相关文献，对3例恶性血液病患者异基因造血干细胞移植后发生闭塞性细支气管炎综合征的临床特点和诊断治疗进行分析。3例患者移植后造血功能均顺利重建，2例未发生急性移植物抗宿主病，1例发生II度急性移植物抗宿主病；3例患者分别于移植后5，6，6个月发生广泛型慢性移植物抗宿主病，经治疗后病情仍有反复；3例患者分别于移植后9，7，11个月发生闭塞性细支气管炎综合征，给予免疫抑制剂、静脉免疫球蛋白、阿奇霉素及局部使用β2受体激动剂及布地奈德吸入治疗，2例在治疗4周后病情有所改善，另1例病情无改善。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。