抗惊厥的

RESULTS: Both two recipes showed potent antifebril,anticonvulsive and sedative effects.

采用酵母引起的大鼠发热模型、伤寒副伤寒疫苗引起的兔发热模型、士的宁致小鼠惊厥及电惊厥模型等观察了2种配方的解热、抗惊厥和镇静作用。

MethodsⅠMaximal electroshock seizure was adopted to analyse the relative of dose and effect, relative of time and effect, including maximal efficacy and potency of these five extractives in mice given by ig administration.ⅡMetrazol seizure test was used to compare seizure latency, anticonvulsant rate and mortality of mice with every extractives.ⅢPharmacodynamic parameters of five alcoholic extractives were assayed by means of Pharmacological Effective Method.ⅣUsing the model of seizure rats induced by penicillin localized injected in cortex,we studied the effect of extractives on seizure latency, frequency of epileptiform discharge, highest wave of hippocampus EEG(Recoded by RM6240C multichannel physiological signal collection and analysis recorde), the changes of convulsant behaviors and the latency of seizure.

方法①采用最大电休克惊厥模型，分析灌胃小鼠各药的量效和时效关系，比较其效价强度和效能；②采用戊四唑惊厥模型，比较ig小鼠各药的惊厥潜伏期、抗惊厥率和死亡率；③采用药效法，运用数学模式及参数来模拟各药在体内的药效动力学过程；④制备大鼠皮层定位注射青霉素点燃模型，采用RM6240C型多道生理信号采集处理系统记录脑电图，比较ig各药对痫性发作潜伏期及发作程度、痫性放电潜伏期、痫波发放频率及最高波幅的影响；⑤采用HPLC法测定海马区癫痫相关递质的含量，比较各药对Glu、Asp、Gly、GABA的影响。

The results showed that,irradiated fresh ginsengs have significant effects against lack of oxygen,diuresis and fa-tigue of mice.

结果表明，辐照保鲜参具有显著的抗缺氧、抗惊厥、抗利尿、抗疲劳效应。

Methods The compound preparation was administered intragastrically in mice, whose spontaneous activity was observed along with their tolerance of the preparation after long-term administration. The hypnotic effect of the compound was assessed by investigating the changes in the pentobarbital sodium-induced sleeping. The compound was tested for its antiseizure effect in mice with pentetrazole-induced clonic and tonic convulsion. Diazepam was used as the standard control in all experiments.

利用光电计数法观察灌胃给予复方酸枣仁油栀子油对小鼠自发活动的影响，以及长期使用药物对小鼠耐受性的影响；利用延长戊巴比妥钠睡眠时间实验和戊巴比妥钠阈下催眠剂量实验，观察复方酸枣仁油栀子油的催眠作用；利用戊四氮诱发小鼠阵挛性、强直性惊厥观察复方酸枣仁油栀子油的抗惊厥作用；本实验用地西泮进行平行对照实验，并进行了组方设计和实验。

Methods Sample dosages were used 15mg,20mg,25mg/ by gstro gavage.The conrulsion rates was induced by maximum electric shock,ip cardiazin mice and lateral intracereral injection of curine in rats were observed.

方法采用克癫胶囊251、5、20mg/灌胃给药，观察最大电休克致小鼠惊厥率和筒箭毒碱侧脑室注射致大鼠惊厥率及戊四唑诱发小鼠惊厥的抗惊厥作用。

Methods The effects of Wuweizi Ningshen Oral Liquid on sedation,hypnotics and anti-convulsion in mice were observed by counting spontaneous behavior,prolonging sleeping time cooperated with pentobarbital sodium and antagonizing convulsion induced by Nikethamide injection.

采用镇静、催眠、抗惊厥实验观察五味子宁神口服液对小鼠自主活动的影响，协同戊巴比妥钠对小鼠的催眠作用及对小鼠尼可刹米惊厥的抑制作用。

MethodsThe effects of Wuweizi Ningshen Oral Liquid on sedation,hypnotics and anti-convulsion in mice were observed by counting spontaneous behavior,prolonging sleeping time cooperated with pentobarbital sodium and antagonizing convulsion induced by Nikethamide injection.

方法采用镇静、催眠、抗惊厥实验观察五味子宁神口服液对小鼠自主活动的影响，协同戊巴比妥钠对小鼠的催眠作用及对小鼠尼可刹米惊厥的抑制作用。

Methods To establish amygdala kindling models in rats and observe the effect of dizocilpine on kindling models and its combination with general antiepileptic drugs (phenobarbital, valproate and nicardipine) at ineffective dose. The influence of dizocilpine on convulsions induced by semicarbazide in mice were also observed.

方法建立大鼠杏仁核慢性电刺激点燃模型，测定不同剂量的MK-801对点燃模型各项指标的影响，探讨MK-801与其他抗癫痫药的协同作用，用氨基脲诱发的小鼠惊厥模型测定MK-801抗惊厥作用。

Aim To investigate the synergistic effect of the combination of pinellia total alkaloid and uncaria total alkaloid, and explore the mechanism of anticonvulsant action.

目的 研究半夏生物总碱和钩藤生物总碱抗惊厥的协同作用，并探讨其相互作用机制。

Some anti-convulsant drugs are used in the long-term treatment of epileptics.

有些抗惊厥的药物，长期使用来治疗癫痫。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。