抗原

The effectiveness of a new antigenic preparation, urea-soluble antigen of Paragonimus skrjabini adult worm, was compared with the conventional saline-extracted antigen of P.s in intradermic test.

本文比较了一种新型抗原制剂斯氏狸殖吸虫成虫尿素溶解性抗原与该虫常规盐水浸出抗原的皮试效果。结果表明，在425名受试者中，PsAWU和PsAWS的皮试阳性率分别为10.3％(44/425)和10.8％(46/425)。

Leishmania promastigotes antigens have good stability and heat-resistant nature. The sensitivity of 901 and 801 antigen were better, so we thought it could be used for serologic epidemiology investigation in XinJiang.

利什曼原虫前鞭毛体抗原有较好的稳定性，耐热性极好；901株、801株抗原的敏感性、特异性较好，可做为新疆血清流行病学调查所用的抗原株；801株的特异性更好，可用于黑热病的特异性抗体的检测及研究。

Results The data were positively related to the antigen cotent in a limited rang. As the relationship between the antigen content and the data of ELISA assay were analysed with 2 - log curve, it was feasible to compare the allergen activities , and to predict the difference of mite allergen products.

结果当抗原含量在一定范围时，抗原含量与ELISA结果成正相关，利用双对数曲线分析抗原浓度与ELISA结果的关系，既能反映变应原的相对含量和活性，又能预测不同变应原溶液中变应原组成成分的差异。

The new antigen P3 peptide which harvested from the 430A peptide synthesizer were verified by the mass spectrograph and HPLC, that the ratio of mass/charge of the synthetic peptide was equal to the molecular weight in theory and its purity was above 95%. The Western blot analysis show that the antiserum induced by the new antigen plus hemocyanin could bind with the 22KD and 55KD proteins, which were existed in the testis tissue protein of mouse, rat and human.

一、经抗原分子设计，在430A自动肽合成仪上合成的新抗原P3，经质谱仪分析证明其荷质比与理论一致；纯化后，其纯度大于95％；将新抗原与KLH偶连后免疫小鼠，经Western blot证实其诱导的特异性抗体可识别小鼠、大鼠、人睾丸组织中分子量约为22KD和55KD左右的蛋白质。

Part Ⅱ Objective: To study the immunoprotective and the immunotherapic effects of the new nucleic acid vaccine of the hepatitis B: pVAX1-C3d-S2S; respectively in normal and HBV transgenic mice after being inoculated intra- muscularly with this Eukaryotic Expression Plasmid, such as the in situ production of the expressed protein in muscle tissue section and specific humoral immune response in normal mice、the variation of specific antigen、antibody and HBV DNA, especialy the changes of specific antigen in liver.

第二部分新型乙肝核酸疫苗pVAX1 C3d-S〓S免疫预防效应和治疗作用的研究目的：研究含有新型分子佐剂补体C3d的HBV adw血清型的乙肝核酸疫苗重组真核表达质粒pVAX1-C3d-S〓S接种正常BALB／c小鼠和HBV转基因小鼠后，其免疫预防作用（接种局部肌肉中特异性抗原蛋白的表达和所诱生的体液免疫应答规律）以及免疫治疗作用（血清中特异性抗原的表达、特异性抗体的产生、HBV DNA的消长和肝组织中抗原表达的变化）。

Parasite nucleic acid vaccine,a new type of vaccine emerging and developing in recent years,can induce not only humoral immunity,but also a high level of cellular immune responses.Parasite DNA vaccine displayed a great advantage in the prevention of parasitosis.

核酸疫苗(nueleie aeid vaeeine，DNA vaeeine)，也常被称为基因疫苗是指将编码某种抗原蛋白的外源基因直接导人动物细胞内，并通过宿主细胞的表达系统合成抗原蛋白，诱导宿主产生对该抗原蛋白的免疫应答，以达到预防和治疗疾病的目的。

It is of great importance to find out the antigenic epitope of TRP-2 as an antigen in pigmental cells, hi order to set up a foundation to investigate the epitope of TRP-2, we studied on the cloning and expression of human TRP -2 code gene.

确定其抗原表位对于深入研究该抗原及临床应用具有极其重要的意义，为了给TRP—2抗原表位确定的研究打下基础，本研究克隆了人TRP—2编码基因并表达了TRP—2蛋白。

As an ideal prime immunization vaccine,the DNA vaccine has the advantages of high purity,continuous expression of antigens with low dose, repeatable immunization and inducement of memory CTL with high titer.Similarly, recombinant virus can not only highly express the target antigen,simulate the inducement process of virus infection on body immunity,and induce various cytokines,but also be beneficial to the interaction of high-affinity antibodies with T cell receptors,and the generation of Th1 reaction and CTL reaction.

DNA疫苗抗原纯度高，持续表达低剂量的抗原，可多次重复免疫以及诱导高效价记忆性细胞毒性T淋巴细胞反应，是理想的用于初次免疫的疫苗；重组病毒能高效表达目的抗原，模拟病毒感染诱导机体免疫的天然过程，能诱发多种细胞因子，而且有利于高亲和性抗体和T细胞受体的选择，可以有效地产生Th1型和CTL反应。

The Nature of Antibodies and the Immune Response in Rainbow Trout.

抗体是由抗原免疫后产生的，与某一抗原专一性地结合，特异性程度高；而凝集素是天然存在的，不需经过免疫而产生，能与多种抗原发生凝集反应，具有非特异性。

In order to inhibit the variation and second variation of Trypanosome, a predominant VSG antigenic reservoir has been established by purification VSG from VAT, leading to a better immune protection and overcome immune failure due to antigenic variation.

我们设想提纯全部优势变异体 VSG，建立优势 VSG 抗原库，期望该抗原库能抑制虫体变异或抑制虫体的第二次变异，从而对动物起到较好的免疫保护作用，克服因抗原变异引起的免疫失败。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。