抗原

It was worth to note that the HI titer of monovalent vaccine immunized group challenged with the same type reached the peak earlier than that challenged with different type virus, whereas there was no such difference among multivalent vaccine immunized groups. It suggested that NDV immunogenicity among epizootic isolates and vaccine strains were also variable in some extent.

单价免疫组鸡对相同基因型NDV 刺激产生的回忆反应要比对具有不同基因型NDV 刺激产生的时间要早，多价灭活苗免疫组对抗原刺激产生的回忆反应基本相同，说明不同流行株在抗原性上存在一定的差异。

As showed above, we could draw the conclusion that H3 viruses could cause outbreaks or local epidemics in Shanghai for the immune of population to the new emerging antigenic drift was still unknown though there was strong immune barrier to the previous vaccine strain, H1 viruses also may caused epidemics as the population had a weak immune protection to the previous reference strains A/New Caledonia/20/99-like and part of the recent isolates were distingwishing from them and continued to evolute on the new reference strain, and H5N1 HPAI activities has expanded its geographical range thus increasing the size of the population at risk as the continuing emergence of human cases which give the virus an opportunity to evolve towards a fully transmissible pandemic strain. We should keep eyes on the human cases of avian influenza virus an its variation for the H5 isolates in Shanghai also has the possibility to infect human directly and the infection of H5, H9 viruses had previously occurred in the population especially in those contacting with animals.

综合上述分析结果，我们认为上海地区人群虽然对原有的H3亚型参考病毒株有较高的免疫保护，但H3亚型病毒HA已出现新的抗原漂移，人群现在对新变异株的保护水平尚未知，有可能在未来引起局限性暴发甚至地方性流行；人群对H1亚型流感病毒免疫保护水平低，同时H1亚型流感病毒株部分与原推荐疫苗株抗原性差别较大，并在现推荐疫苗株基础上继续变异，需警惕发生流行的可能性；H5N1亚型高致病性禽流感地域范围扩大，人间病例不断发生，存在演变成大流行株的威胁，上海市H5亚型禽流感病毒株存在跨宿主屏障感染人类的可能性，而且已发现人群尤其禽、畜类动物接触人群中存在H5、H9亚型流感病毒的既往感染，应警惕禽流感病毒的变异和人间病例的发生。

The key point for constructing the novel recombinant exotoxin fusion protein B7-PE40 KDEL was to preserve the molecular biology characteristics of themselves, such as flexibility, antigenicity, hydrophilicity, epitope and secondary structure and to enhance their cytotoxic activity.

分子构建成功新型重组B7-PE40KDEL融合蛋白的关键在于，要使所构建的B7-PE40KDEL能分别保留B7-1、B7-2和PE40KDEL各自的表位特征、没有新的抗原表位产生、柔性接头处具有极低的抗原性以及具有更强的杀伤效力。

Objective To evaluate serum tPSA 、f/t ratio and PSAD in the differential diagnosis of BPH and Pca.

目的 比较血清总前列腺特异抗原、游离PSA与tPSA的比值、前列腺特异抗原密度鉴别前列腺增生和前列腺癌的价值。

Objective To evaluate the clinical significane of F PSA/PSA ratio and the change rate of PSA concentration in the patients with PSA between 4 to 10 μg/L.

目的 评价游离前列腺抗原/前列腺抗原比值和PSA动态变化在前列腺癌诊断中的应用价值。

A multiplex PCR assay for detection of Escherichia coli O157:H7 was developed by using 3 sets of primers that specifically amplify segments of the rfbE、fliC and eaeA genes. The target genes fragment of the PCR assay were 291 bp, 625 bp and 368 bp, respectively. Analysis of 30 strains demonstrated that this PCR system was specific.

以编码大肠杆菌O157抗原的rfbE基因、编码H7抗原的fliC基因以及编码毒力因子的eaeA基因为靶基因，选择3对引物，建立并优化了检测大肠杆菌O157：H7的多重PCR体系，扩增产物分别为291 bp、625 bp、368 bp，采用30株细菌验证了该多重PCR具有特异性。

The results showed that all of the four McAbs against core glycolipid of bacterial lipopolysaccharides(anti-CGL McAbs) were cross-reactive with various type of lipopolysaccharides of Gram-negative bacteria.

常见的革兰氏阴性菌及其LPS均有较强的抑制EL3和3H4结合抗原的作用，EL1和EL2的结合抗原反应也可明显被E。

In order to detect the distribution of silica-binding proteins in rice and other graminaceous plants, specific polyclonal antibodies against a silica-binding protein from rice, namely SBP117, are successfully raised by synthesized peptides Which are conjugated with Keyhole Limpet Hemocyanin and used as antigens to immunize rabbits.

为了检测硅结合蛋白在水稻和禾本科植物体内的分布，根据硅结合蛋白(silica-binding protein 117， SBP117)的氨基酸保守片段和天然抗原表位，合成了SBP117的两个肽段做抗原，与匙血蓝蛋白载体偶联后免疫兔子，获得了抗SBP117的专一性抗体。

The chief offending antigen in haemolytic disease of the newborn is antigen D of the rhesus series.

新生儿溶血病起主要作用的抗原是RH系列的抗原D。

KIR bind corresponding HLA-Ⅰmay hame four results followed:1、When inhibitory KIR bind HLA-Ⅰand there has no activatory KIR bind it,cell isn\'t dissolve because inhibitory signal access was done;2、When activatory KIR bind corresponding HLA-Ⅰand there has no inhibitory KIR bind it,form activate signal,lead cell dissolve.3、If activatory or inhibitory receptor both bind HLA-Ⅰ,both signal access is make done,when activatory signal play the main role,NK cell still actived,lead target cell dissolve.4、If activatory or inhibitory receptor both bind HLA-Ⅰ,both signal access is make done,when inhibitory signal play the main role,or both signal access don\'t play,NK cell do not make effect.this is NK cell recognice nomal tissue.

与活化型KIR受体相比，抑制型KIR受体与HLA-Ⅰ类抗原结合的亲和性更强，当抑制型和活化型KIR受体识别和结合同一HLA-Ⅰ类抗原分子时，以抑制作用为主。KIR与相应HLA-Ⅰ结合后可能产生以下4种情况：①当抑制型KIR与HLA-Ⅰ结合而无活化型KIR与HLA-Ⅰ相互作用时，因抑制信号通路启动而不产生细胞溶解；②当活化型KIR与靶细胞表面的相应HLA-Ⅰ结合同时无抑制型KIR与HLA-Ⅰ的相互作用时，形成刺激信号通路，导致靶细胞溶解。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失