抗原

For example, HLA associations with vitiligo include HLA-DR4 in Caucasian Americans, DR4 and DQW3 in black Americans, DR4 and DR6 in a Dutch caucasoid population, DR7 and DQW3 in north Italians, DR7 in Omanis, DR1 in Hungarians, DRW12 in north Germans, and DW7 in Slovakians. Negative association of DR1, DR3 and DR52 were observed in north Italians. With the DNA typing of HLA, it was found the frequencies of HLA-DRB1〓0701, DQB1〓0201, DPB1〓1601 alleles were significantly increased in Slovak patients and DRB4〓0101 were increased in Dutch patients.

此后发现美国黑人与DR4、DQW3明显相关；匈牙利、德国和斯洛伐克患者中，HLA-DR1、DRW12和DW7抗原频率分别升高；HLA-DR7与意大利患者明显相关，而DR1、DR3则明显降低；荷兰患者中HLA-DR4和DR6抗原频率明显升高，而DR3明显降低；HLA-DR7与阿曼人明显相关，而肢端型又较局限型明显升高。90年代后，DNA分型法用于HLA的研究，发现斯洛伐克患者与HLA-DRB1〓0701、DQB1〓0201、DPB1〓1601明显相关；荷兰患者的DRB1〓0400，〓0901，〓1300、DRB4〓0101、DQA1〓0301、DQB1〓0302，〓0303基因频率升高，而DRB1〓1100、DQA1〓0501降低，但经校正后，仅DRB4〓0101有显著意义。

Bone morphogenetic protein -2 induces the expression of cementum attachment protein in human periodontal ligament clones ［J］.

本研究通过比较骨髓基质细胞与正常人牙周韧带细胞表面抗原的表达情况，证实牙周韧带细胞与骨髓基质细胞在表面抗原的表达上相似。

The purified N protein was used to coat 96-well plate, each step was optimized, such as coating concentration of recombinant nucleocapsid protein, scample dilutim, chromogen and stop solution as well as concentration.

在此基础上，以纯化的重组N蛋白作为包被抗原，对各种条件进行优化（如抗原的包被，作用时间及底物的选择），确定了判定标准，建立了检测PRRS抗体的间接ELISA方法。

The concordance of results between the ELISA test and the TPPA test was 99%.

表达的4种重组抗原具有很好的生物活性，为理想的梅毒的血清学诊断用抗原。

Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞，导致细胞生长的抑制和凋亡罗伯托利，斯特凡Purgato ，苏埃洛卡默琳，拉菲尔Fronza ，梅奥尼博洛尼亚，西蒙娜Alboresi ，莫妮卡弗兰索尼，罗伯托Corradini ，斯特凡诺斯福尔扎，安德烈Faccini ，杰森先生Shohet ， Rosangela Marchelli ，和安德烈Pession儿科，博洛尼亚大学，圣' Orsola -马尔皮基医院，博洛尼亚，意大利；有机部和工业大学化学帕尔马，帕尔马，意大利和3Center的细胞和基因治疗，德州儿童癌症中心， Baylor医学院，得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞，针对一个独特的序列反义DNA链的第2外显子，并与在MYCN 其氨基端为核定位信号肽。

Fertilization antigen 1 (FA-1) is an evolutionarily conserved antigen present in sperm of various mammalian species including mouse, rabbit, bull, rhesus monkey and human. It seems to have similar function and, shown to have cross-reaction among these species.

受精抗原1(Fertilization Antigen 1)是一在进化上比较保守的抗原，在多种哺乳类动物包括小鼠、家兔、牛、猕猴以及人的精子表面均存在，并具有相似的功能，FA-1在不同物种间存在交叉反应。

Results When Raji and B95-8 cells were cultured with 20-80 μg/ml of "Dongxia wan", the expression of EBV early antigen and EBV capsid antigen induced by croton oil and n-butyric acid and the natural expression of EBV-VCA were all inhibited significantly. The inhibition rates were 19.3%-49.84%, 34.63%-45.61% and 21.67%-47.78% respectively.

结果 20～80 μg/ml中药复方"冬夏丸"与靶细胞共培养能显著的抑制巴豆油和正丁酸联合诱发Raji细胞的EBV早期抗原和B95-8细胞的EBV壳抗原表达及B95-8细胞的EBV-VCA自然表达，抑制率分别是19.31%～49.84%，34.63%～45.61%和21.67%～47.78%。

The hapten can be synthesized with a spacer attached at the aromatic moiety of the pyrethroid, through the middle of the molecule and at the cyclopropane moiety.

半抗原的合成入手点主要为菊酯分子的三碳环、中间和芳环部分，连接一个连接臂作为半抗原。

At the beginning, HLA class I/peptide complex teramer was prepared, including the most frequent alleles in Chinese, i.e., HLA-A2 and HLA-A24. Then the aAPCs were assembled by coating a cell-sized bead with pMHC and anti-CD28 antibody, which were able to provide the dual signals required for T cell activation, and used as stimulator to generate pMHC-specific CTL by co-culture with allogeneic peripheral blood lymphocyte.

首先制备包括我国人群基因频率最高的HLA-A2，HLA-A24的HLA/抗原肽四聚体，在此基础上，制备能够为T细胞提供第一、第二活化信号的aAPC，其表面包被的HLA/抗原肽复合物容易控制，用于诱导同种个体的T细胞产生同种CTL。

Its principle is to sample the antigens and a certain amount of competition and the solid-phase ELISA antigen-antibody binding.

其原理是标本中的抗原和一定量的酶标抗原竞争与固相抗体结合。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失