抗凝血素

Natural hirudin is the most powerful natural anticoagulant in the world until now.

天然水蛭素是目前功能最强大的天然抗凝血剂，在世界上到现在。

Louis, Missouri, presented results of a meta-analysis of 11 clinical trials, involving nearly 5,000 patients with sepsis; approximately 1,800 received aPC, a little more than 2,600 received antithrombin III, and nearly 300 received tissue factor pathway inhibitors.

Freeman博士则整合11个临床试验加以研究，这份研究的背景包括近5，000位败血症患者，其中约1，800位接受aPC治疗， 2，600多位患者接受抗凝血酵素的治疗，近300位患者则接受组织因子路径抑制物治疗。

The 62 deadly allergic reactions in people who used the blood-thinner heparin may be traced back to China.

62名因使用疑似来自中国的抗凝血素产生了强烈的过敏反应。

"Anti-platelet drugs are often used to reduce intima thickening, for example, restenosis...after angioplasty. Perhaps a different method of inhibiting platelet activation would be to drink dealcoholized beer," Dr. Bassus says."Conversely, the acute consumption of alcohol beverages causes an increase of thrombin generation, suggesting a thrombotic risk in case of acute alcoholic intoxication."

抗血小板药物一般被用来降低血管内膜的肥厚症状，如该药物可预防血管修复手术后的血管狭窄现象，Bassus表示，也许抑制血小板活化的另一种方法就是投予去醇啤酒，然而，过度的酗酒反而会造成凝血酵素的增生，也就是说，急性酒精中毒通常会有缺血的风险。

The major results obtained are: PCR-RFLP method is suitable for molecular identification of Shihu; 205 compounds were isolated from 10 species of Dendrobium, including 21 new compounds, and 28 compounds isolated from genus Dendrobium for the first time. Each of the extracts and compounds were screened for anticoagulant and antitumour activities separately. The results indicated that the ethyl acetate extract from Dendrobium chrysanthun has significant anticoagulant function; the antitumour function of the 4 bibenzyl components from Dendrobium chrysotoxum is stronger than that of phenanthrene, of which the erianin has significant anti-angiogenic effect both in vivo and in vitro; components with moderate or stronger antitumour activities were found in the extracts of D. thyrsiflorum, D. chrysanthun and D. trigonopus; quality standard for 5 species of Dendrobium was drawn up use active or indicative components as control.

重要研究结果有：经方法学研究，认为PCR-RFLP法适于作为石斛属药材分子标记鉴定方法；对10种石斛进行化学成分分离鉴定，共分得205个化合物，其中新化合物21个，首次从石斛属分得的28个；对提取物和各单体化合物分别作抗凝血、抗肿瘤等活性筛选，结果说明束花石斛乙酸乙酯部位有显著的抗凝血作用，鼓槌石斛的4个联苄类成分抗肿瘤作用强于菲类，联苄类毛兰素在体内外有显著抗血管生成活性，球花石斛、束花石斛及翅梗石斛均筛到中等或较强抗癌活性的成分；选择有活性或指标性成分作对照品，对5种石斛草拟了质量标准。

Methods:The fresh porcine blood added sodium citrate was used for extracting of heme. The methods of hematolysis by water,ethanol and supersonic wave were compared.

新鲜抗凝猪血为原料，比较了水溶胀法、乙醇法以及超声波法对红细胞溶血效果，以盐酸丙酮配比，盐酸丙酮与溶血液体积比对猪血中血红素提取的影响。

Methods: K3 EDTA peripheral blood of 40 healthy volunteers was dealt with a self-made lysing solution and a FACS Lysing solution, and then the lysing effect on red blood cells and the influence on CD14(superscript +), CD45(superscript +) on lymphocytes, monocytes and granulocytes were detected.

应用流式细胞术对40份K3 EDTA抗凝外周血分别用自制流式细胞仪专用溶血素与FACS溶血素处理后，检测其对血液红细胞的溶解效果及对淋巴细胞、单核细胞和粒细胞表面特异性抗原CD14、CD45表达率的影响。

Methods: K3 EDTA peripheral blood of 40 healthy volunteers was dealt with a selfmade lysing solution and a FACS Lysing solution, and then the lysing effect on red blood cells and the influence on CD14+, CD45+ on lymphocytes, monocytes and granulocytes were detected.

应用流式细胞术对40份K3 EDTA抗凝外周血分别用自制流式细胞仪专用溶血素与FACS溶血素处理后，检测其对血液红细胞的溶解效果及对淋巴细胞、单核细胞和粒细胞表面特异性抗原CD14+、CD45+表达率的影响。

METHODS: After isolated the PBMCs and blood-plasma from adult human peripheral blood by Ficoll-Hypaque centrifugation, the PBMC culture procedure with or without the self-blood -plasma was applied to polarize T cells in vitro , these cells were polarized by PHA(20 mg/L),non-PHA respectively.

用Ficoll-Hypaque梯度离心法分离出正常成人抗凝外周血单个核细胞和血浆，将PBMC置于含或不含有自身血浆环境中，并在植物血凝素(PHA ，2 0mg L)的刺激下进行培养，培养 2 4、48、72h后收获细胞，分别用双色免疫荧光标记，以流式细胞术对CD4+ T细胞表达表面分子CCR3、CCR5进行分析。结果：CD4+ T细胞受自身血浆和PHA刺激后向Th1 Th2两个方向极化，2 4、48、72h后极化率分别达到(13 2 8± 1 5 9)%(12 70± 1 6 5 )%、(17 19± 1 0 3)%(17 5 0± 1 30 )%、(19 49± 2 87)%(18 5 8± 1 49)%；而只有PHA刺激的极化率很低，两组有显著性差异(P 0 1)；Th1∶Th2之比约等于 1。

These enzymatic haemostatic agents can be used to antagonize the side effect of hirudin. We take the batraxobin as an example to illustrate that the enzymatic haemostatic can antagonizes hirudin. Agglutination reaction occurred after the tubes containing hirudin were added with batroxobin , i.e., batroxobin can antagonize hirudin. In a canine model,, the reduction extent of TT and APTT in the test group was larger than that in the control group; the bleeding time was decreased obviously and it was shorter in the experimental group than in the control group at lh, 2h and 3h after hirudin injection, indicating batroxobin can antagonize the bleeding side effects of hirudin.

以巴曲停为例，加入巴曲停的水蛙素抗凝试管内又可发生凝集反应，而未加入巴曲停的试管内不发生凝集反应；犬动物模型显示，水蛙素实验组TT值、 APTT值明显低于水蛙素对照组，犬给予巴曲停后出血时间明显缩短，出血时间在滴注水蛙素后lh、2h、3h明显短于对照组(P.05)，说明巴曲停有拮抗水蛙素抗凝血的作用。

Neither the killing of Mr Zarqawi nor any breakthrough on the political front will stop the insurgency and the fratricidal murders in their tracks.

在对危险的南部地区访问时，他斥责什叶派民兵领导人对中央集权的挑衅行为。

In fact,I've got him on the satellite mobile right now.

实际上 我们已接通卫星可视电话了