抗关节炎药

The invention relates to the isolation and preparation of an active fraction from plant Cuminum cyminum, its further purification and standardization as chemically defined entity with their intended use as drug bioavailability enhancer for the drugs belonging to therapeutic categories such as antimicrobial, antifungal, anti-viral, antitubercular, antileprosy, anti-inflammatory, antiarthritic, cardiovascular, antihistaminics, respiratory distress relieving drugs, immunosuppressants, anti-ulcerogenic, anti-cancer, CNS drugs, corticosteroids, nutraceuticals in compositions to be administered orally/parenterally, topically, inhalations, rectally, vaginally in human beings and/or veterinary conditions.

本发明涉及植物孜然芹中的一种活性级分的分离和制备，进一步的纯化以及它作为化学确定实体的标准化，和它作为治疗类药物的生物利用率增强剂的特定用途，这类药物包括如抗微生物剂、抗真菌剂、抗病毒剂、抗结核药、抗麻风病药、抗炎药、抗关节炎药、心血管类药、抗组胺药、呼吸窘迫缓解药、免疫抑制剂、抗溃疡药、抗癌药、CNS药、皮质甾类药、营养制品，它们以组合物的形式通过口服/肠胃外，局部，吸入直肠，阴道施用于人和/或兽医学病症中。

It is concluded that this culture may provide a valuable material for pathological study of rheumatoid arthritis and the screening of antirheumatic drugs.

本实验为研究类风湿性关节炎的病理及筛选抗风湿药提供了理想的实验材料。

Currently,the most acceptable medical treatment strategy for rheumatoid arthritis is the early application of the disease modifying antirheumatic drugs to the premise of the early diagnosis.

目前，针对类风湿关节炎的药物治疗，主张在早期诊断的基础上尽早应用改善病情的抗风湿药。

Other anti-inflammatory medications known as disease-modifying antirheumatic drugs, such as methotrexate, are often used, but GRAPPA found that the medications are often not effective for psoriatic arthritis, even though they can be very useful for treating rheumatoid arthritis, Ritchlin said.

其他抗发炎药物被称为疾病的修改药，如甲氨蝶呤，常常使用，但格拉巴发现该药物往往不能有效的银屑病性关节炎，即使他们可以是非常有用的治疗类风湿关节炎， Ritchlin说。

Since its first description, CIA has been widely used as a powerful tool to study immune responses in arthritis, analyze genetic susceptibility factors, unravel inflammatory pathways, and explore the therapeutic effects of potential antirheumatic drugs.

自从它被首次描述以来，CIA作为一种强有力的研究工具广泛地用于研究关节炎免疫应答，分析基因易感因子，揭示炎症反应途径，以及开拓可能抗风湿药的治疗作用等方面。

The following observation time was 1～3 years ,average 20 months .All fractures were ostcal concrescence. Two cases were evaginate about 5 degree. Three cases were open injury and needed flap grafting rehabilitation because skin and soft tissue were compressed severely and necrotized.

结果］术后78例均获得随访，随访1～3年，平均20个月，所有骨折均骨性愈合，2例有约5°左右外翻，3例开放损伤患者因皮肤、软组织挫压明显缺血坏死需Ⅱ期行皮瓣移植修复治疗，4例出现创伤性关节炎症状，需服用非甾体类抗炎药，其中1例行踝关节融合术。

All fractures were ostcal concrescence. Two cases were evaginate about 5 degree. Three cases were open injury and needed flap grafting rehabilitation because skin and soft tissue were compressed severely and necrotized. Traumatic artharitis occurred in 4 cases,nitric oxide-releasing anti-inflammatory drug was needed. One case was treated with arthrodesis .

结果］术后78例均获得随访，随访1～3年，平均20个月，所有骨折均骨性愈合，2例有约5°左右外翻，3例开放损伤患者因皮肤、软组织挫压明显缺血坏死需Ⅱ期行皮瓣移植修复治疗，4例出现创伤性关节炎症状，需服用非甾体类抗炎药，其中1例行踝关节融合术。

BACKGROUND: Conservative treatment of osseous gonarthritis is mainly to reduce the loading of knee joint and maintain muscle exercise,and non-steroidal anti-inflammatory drugs serve as supplements in case of acute occurrence.

背景：骨性膝关节炎保守治疗一直以尽量减少膝关节负重及保持肌肉锻炼为主，急性发作时辅以非类固醇抗炎镇痛药。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。