抑素的

In order for a peptide like this to be used in humans it would hae to be taken for many years, much like statin medications for cholesterol," said Dr. Sadowski, whose research has been supported by a Paul B. Beeson Career Deelopment in Aging a grant jointly funded by the American Federation of Aging Research and the National Institute on Aging."Our ongoing research is now focusing on transforming the peptide used in the study into an agent that could be used clinically.

Sadowski博士的研究受美国联邦老年研究中心和国际老年学院赞助的赞助和Paul职业发展中心的支持，他指出就像生长抑素胆固醇一样，这种肽用于人类还需要很多年，我们即将进行的研究将集中在把这种试验中的肽转换成临床可用的试剂。

Here we show that phenylarsine oxide and diamide (both were inhibitors for protein tyrosine phosphatases), but not genistein (an inhibitor for protein tyrosine kinases), adenosine, wortmannin and LY294002 (all were inhibitors for phosphatidylinositol 3- and 4-kinases), could inhibit P-selectin exocytosis on activated platelets and could abolish the P-selectin mediated aggregation of activated platelets to neutrophils.

我们发现蛋白酪氨酸磷酸酶的抑制剂phenylarsine oxide和diamide能够抑制P-选凝素从活化的血小板中外排出来，并能够抑制P-选凝素介导的活化的血小板在白细胞表面的粘附，而蛋白酪氨酸激酶的抑制剂genistein，磷脂酰肌醇3-或4-激酶的抑制剂adenosine、wortmannin和LY294002在这些实验中没有作用。

Here we show that phenylarsine oxide and diamide (both were inhibitors for protein tyrosine phosphatases), but not genistein (an inhibitor for protein tyrosine kinases), adenosine, wortmannin and LY294002 (all were inhibitors for phosphatidylinositol 3-and 4-kinases), could inhibit P-selectin exocytosis on activated platelets and could abolish the Pselectin mediated aggregation of activated platelets to neutrophils.

我们发现蛋白酪氨酸磷酸酶的抑制剂phenylarsine oxide和diamide能够抑制P-选凝素从活化的血小板中外排出来，并能够抑制P-选凝素介导的活化的血小板在白细胞表面的粘附，而蛋白酪氨酸激酶的抑制剂genistein，磷脂酰肌醇3-或4-激酶的抑制剂adenosine、wortmannin和LY294002在这些实验中没有作用。

renal glomerulus filterability be the judgment renal glomerulus filtration function of importance index sign, but clinical in common use currently measurement gfr method existence certain limit sex.in the near future research enunciation serum cystatin c be a kind of particularity high, accuracy good and sensitive of reaction gfr of new index sign, have importance application in various familiar renopathy.

肾小球滤过率是判断肾小球滤过功能的重要指标，但目前临床常用的测定gfr的方法存在一定局限性。近期研究表明血清胱抑素c是一种特异性高、准确性好且敏感的反应gfr的新指标，在各种常见的肾脏病中有着重要应用。

RLuciferase/Luciferin system, a new method to detect the MAPK activity in fungus, was founded and proved to be effective and perspective in the study of MAPK pathway in microorganism.

建立了一套切实可行的检测MAPK活性的荧光素酶/荧光素技术体系，并发现MAPK途径抑制剂U0126和CaM抑制剂TFP对MAPK活性都有显著的抑制作用。

OBJECTIVE: To discuss the expressions of 2 sub-types of SSTR, SSTR1 and SSTR2 in human salivary gland mucoepidermoid carcinoma(MEC-1 ) and the high metastatic cell strain(Mc3) of human mucoepidermoid carcinoma and the differences of these two receptors in the binding with SSTR radioactive genin, 125I-RC-160, and the correlations with prngnostic rehabilitation.

目的：探讨人涎腺粘液表皮样癌细胞系(MEG-1)及人粘液表皮样癌高转移细胞株(Mc3)生长抑素受体两种亚型(SSTR1、SSTR2)的表达与SSTR的放射配基125I-RC-160的结合差异与预后康复的相关性。

Fie years after initiation of treatment, 79% patients were still on renin-angiotensin inhibitors, 65% on -blockers, 56% on spironolactone, and 83% on statins. Notably, multiple drug treatment and increased seerity of heart failure was associated with persistence of treatment. Nonpersistence with renin-angiotensin inhibitors,-blockers, and statins was associated with increased mortality with hazard ratios for death of 1.37 (95% CI, 1.31 to 1.42), 1.25 (95% CI, 1.19 to 1.32), 1.88 (95% CI, 1.67 to 2.12), respectiely.

开始治疗5年后，有79％病人继续使用肾素血管紧张素抑制剂，65％用阻滞剂，56％用安体舒通，83％使用他汀类，值得注意的是，联合用药和心衰的加重同坚持治疗相关，无法坚持使用肾素血管紧张素抑制剂，阻滞剂，安体舒通，他汀类药物的病人同增加的死亡率相关，其死亡危险比分别为1.37 (95%可信区间， 1.31 － 1.42)， 1.25 (95%可信区间， 1.19 － 1.32)， 1.88 (95%可信区间， 1.67 － 2.12)，。

Results showed that, pyrolin had obvious action on two species of fungi, and the antifungal effect was positively correlative with concentration. The EC50 was 0.4076 mg/mL and 0.4626 mg/mL respectively after cultured 3 days. The main antifungal period was the fast growth period of fungi, and lead to it lag behind. Observation under SEM revealed that pyrolin caused a series of marked morphological and structural alterations of hyphal. These changes included mutual adhesion of mycelium, the hyphal was irregular in diameter, local denting, some of mycelium was broken, disruption of cell wall, outbreaking of inner cytoplast, and the empty cavity appeared. As a result, pyrolin restrained the growth of these fungi.

结果表明，鹿蹄草素对上述两种真菌均具有明显的抑制作用，抑菌效果与浓度呈正相关，培养3d时的EC50分别为0.4076、0.4626 mg/mL；抑菌时期主要是在真菌的快速生长期，使其快速生长期滞后；扫描电镜显示，鹿蹄草素作用下菌体形态发生异常变化，表现为菌丝体之间相互粘连，菌丝粗细不均匀，细胞壁破裂，局部凹陷，部分菌丝断裂，大量内容物外溢，出现空腔等现象，从而发挥其抑菌作用。

Results: 1 Tritiated thymidine incorporation assay showed that 1μM adenosine plus coformycin slightly inhibited CTLL-2 proliferation, while 5-20μM adenosine elicited marked inhibition on CTLL-2 proliferation responded to IL-2 a dose-dependent fashion. 2 Coformycin alone could also inhibit CTLL-2 proliferation at the concentration of 2.5μM. The underlying reason maybe due to the endogenous adenosine produced by CTLL-2 cells.

结果：11μM腺苷对CTLL-2增殖仅有轻微的抑制作用，而5、10、20μM腺苷的存在可显著抑制CTLL-2的增殖，并且呈剂量相关，P值均小于0.05.2CTLL-2经过2.5μM助间型霉素的单独处理也可引起轻度的增殖受抑现象，分析其可能原因是T细胞自身可以分泌腺苷，所以该抑制现象的出现与内源性腺苷有关。3本实验所用腺苷浓度对CTLL-2的活细胞百分率影响轻微。

OBJECTIVE: Our objective was to evaluate the short-term efficacy of the novel multireceptor ligand somatostatin analog pasireotide in patients with de novo, persistent, or recurrent Cushing's disease.

目的：本研究的目的是评价新型多受体配体生长抑素类似物pasireotide治疗新发的、长期的或复发性库欣病患者的短期疗效。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！