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Here we show that phenylarsine oxide and diamide (both were inhibitors for protein tyrosine phosphatases), but not genistein (an inhibitor for protein tyrosine kinases), adenosine, wortmannin and LY294002 (all were inhibitors for phosphatidylinositol 3- and 4-kinases), could inhibit P-selectin exocytosis on activated platelets and could abolish the P-selectin mediated aggregation of activated platelets to neutrophils.

我们发现蛋白酪氨酸磷酸酶的抑制剂phenylarsine oxide和diamide能够抑制P-选凝素从活化的血小板中外排出来,并能够抑制P-选凝素介导的活化的血小板在白细胞表面的粘附,而蛋白酪氨酸激酶的抑制剂genistein,磷脂酰肌醇3-或4-激酶的抑制剂adenosine、wortmannin和LY294002在这些实验中没有作用。

Here we show that phenylarsine oxide and diamide (both were inhibitors for protein tyrosine phosphatases), but not genistein (an inhibitor for protein tyrosine kinases), adenosine, wortmannin and LY294002 (all were inhibitors for phosphatidylinositol 3-and 4-kinases), could inhibit P-selectin exocytosis on activated platelets and could abolish the Pselectin mediated aggregation of activated platelets to neutrophils.

我们发现蛋白酪氨酸磷酸酶的抑制剂phenylarsine oxide和diamide能够抑制P-选凝素从活化的血小板中外排出来,并能够抑制P-选凝素介导的活化的血小板在白细胞表面的粘附,而蛋白酪氨酸激酶的抑制剂genistein,磷脂酰肌醇3-或4-激酶的抑制剂adenosine、wortmannin和LY294002在这些实验中没有作用。

In the same concentration, the antibacterial activity of total pigment was much more significantly than fucoxanthin. It seemed that there were also other kind of pigments with much stronger antibacterial activity in Laminaria japonica.

相同浓度下,海带总色素的抑菌活性比褐藻黄素的抑菌活性显著,说明海带总色素中还含有比褐藻黄素抑菌性更强的其他色素。

The radical scavenging activity of Laminaria japonica pigments was studied by the DPPH2,2-Diphenyl~(-1-picrylhydrazylassay. The total pigments showed a strong DPPH radical scavenging activity of 65.819% with the concentration of 0.52mg.ml~(-1). The DPPH radical scavenging activity of fucoxanthin was 19.85% with the concentration of 0.27mg.ml~(-1). The antimicrobial activity of pigment in Laminaria japonica was studied by the method of round paper. The results showed that the pigment extracts have activity against Escherichia coli, Pseudomonas aeruginosa, Saricina flava and Saccharomyes cerevisia. The antibacterial activity of total pigments for Saccharomyes cerevisia was the strongest with an inhibition diameter of 18.9 mm; and the antibacterial activity of fucoxanthin for Saricina flava was also much significant with an inhibition diameter of 10.2 mm.

测定了它们对自由基的清除率和对四种细菌的抑菌效果,研究结果表明,总色素和褐藻黄素的浓度与自由基清除率成正比,当总色素浓度为0.52mg.ml~(-1)时,清除率达到65.819%,高于陆生植物黑米色素和紫甘薯色素;当褐藻黄素浓度为0.27mg.ml~(-1)时,自由基清除率达到19.85%,低于紫苏色素、紫甘蓝色素、黑米色素、紫甘薯色素;对大肠杆菌、绿脓杆菌、八叠球菌、金黄葡萄球菌的抑菌实验结果显示,海带总色素对金黄葡萄球菌的抑菌活性最强,抑菌圈直径为18.9mm;褐藻黄素对八叠球菌的抑菌活性相对较强,抑菌圈直径为10.2mm。

Fie years after initiation of treatment, 79% patients were still on renin-angiotensin inhibitors, 65% on -blockers, 56% on spironolactone, and 83% on statins. Notably, multiple drug treatment and increased seerity of heart failure was associated with persistence of treatment. Nonpersistence with renin-angiotensin inhibitors,-blockers, and statins was associated with increased mortality with hazard ratios for death of 1.37 (95% CI, 1.31 to 1.42), 1.25 (95% CI, 1.19 to 1.32), 1.88 (95% CI, 1.67 to 2.12), respectiely.

开始治疗5年后,有79%病人继续使用肾素血管紧张素抑制剂,65%用阻滞剂,56%用安体舒通,83%使用他汀类,值得注意的是,联合用药和心衰的加重同坚持治疗相关,无法坚持使用肾素血管紧张素抑制剂,阻滞剂,安体舒通,他汀类药物的病人同增加的死亡率相关,其死亡危险比分别为1.37 (95%可信区间, 1.31 - 1.42), 1.25 (95%可信区间, 1.19 - 1.32), 1.88 (95%可信区间, 1.67 - 2.12),。

Human SW480 colonic cancer cell line was evaluated for its growth response to Octa peptide somatostatin (SMS 201·995, SMS) in vitro by MTT assay and flow cytometry.

用MTT比色分析法和流式细胞术研究了8肽生长抑素(SMS 201·995),SMS对人大肠癌细胞株SW480的作用。

AIM: To construct the recombinant human angiostatin expression vector and to detect its expression in hepatocellular carcinoma cells.

目的:构建重组人血管抑素的表达载体并检测其在肝癌细胞系中的稳定表达。

OBJECTIVE: Our objective was to evaluate the short-term efficacy of the novel multireceptor ligand somatostatin analog pasireotide in patients with de novo, persistent, or recurrent Cushing's disease.

目的:本研究的目的是评价新型多受体配体生长抑素类似物pasireotide治疗新发的、长期的或复发性库欣病患者的短期疗效。

Ghrelin is the endogenousli gand for the growth hormone secretagague receptor and at present,except that the growth hormone release hormone and somatostatin, endogenous material that the third regulation GH secreted.

Ghrelin是生长素促泌物受体(growth hormone secretagague receptor,GHS-R)的内源性配体,是目前为止除了生长激素释放激素和生长抑素外,第三个调节GH分泌的内源性物质。

Purpose To study the effects of the expression of endostatin and MVD on progression and prognosis in pancreatic carcinomas.

目的 探讨内皮抑素表达与微血管密度在胰腺癌发生、发展中的作用及对预后的影响。

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