抑素

Tumstatin is the fortest antiangiogenesis factor in present, its effect is more than 10 times as endodermis chalone.

肿瘤抑素是目前发现的最强的血管生成抑制因子，作用强于内皮抑素10倍以上。

Use somatostatin after PD can restrain organism excrete diastase vera,and help anastomotic stoma to concrescent and decrease pancreatic leakage;pancreatic leakage should be treated by different grades,grade 1 can be cured by persistent drainage with somatostatin and nutritional support;grade 2 should be pay more energetic intervention.

PD后应用生长抑素持续泵入可以抑制胰酶的作用，使胰肠吻合口较好地愈合，从而有效地减少胰漏的发生；胰漏可进行分级治疗，Ⅰ级胰漏采用通畅引流为主，同时使用生长抑素和营养支持等治疗多可治愈，Ⅱ级胰漏需要积极治疗。

objective:to investigate the therapeutic action of somatostatin in pancreatic leakage after pancreaticoduodenectomy.methods: to collect 100 patients with pancreaticoduodenectomy during 2003～2006,contrast 44 patients use somatostatin after pancreaticoduodenectomy as experimental group,and 56 patients with conventional therapy as control group.results:there were no pancreatic leakage case in the modified group of 44 cases.3 cases complicating pancreatic leakage occurd in control group,and the proportion of pancreatic leakage are different examined by statistic mathord.conclusions:use somatostatin after pd can restrain organism excrete diastase vera,and help anastomotic stoma to concrescent and decrease pancreatic leakage;pancreatic leakage should be treated by different grades,grade 1 can be cured by persistent drainage with somatostatin and nutritional support;grade 2 should be pay more energetic intervention.

作者单位：潍坊医学院，潍坊 261042；潍坊市人民医院肝胆外科，潍坊 261042 目的：探讨生长抑素在胰十二指肠切除术后减少胰漏的作用。方法：收集2003年1月～2006年12月施行pd患者100例，术后应用生长抑素持续泵入病人44例，并与同期施行的pd术后常规应用全肠外营养及抗生素治疗病人56例，结果进行了对比观察。结果：实验组病人44例无1例发生胰漏，对照组56例病人，3例发生不同程度的胰漏，发生率5.3%，统计学比较有显著差异（p＜0.05）。结论： pd后应用生长抑素持续泵入可以抑制胰酶的作用，使胰肠吻合口较好地愈合，从而有效地减少胰漏的发生；胰漏可进行分级治疗，ⅰ级胰漏采用通畅引流为主，同时使用生长抑素和营养支持等治疗多可治愈，ⅱ级胰漏需要积极治疗。

We compared the spectral and its secondary structure of endostatin with and without of zinc, heparin and lanthanides. It demonstrated that the pH has strong effect on the interaction of endostatin and heparin.

研究了内皮抑素与锌离子、肝素、稀土离子作用后蛋白质的光谱学性质和二级结构的变化，首次发现偏酸性pH对肝素与内皮抑素的结合作用有特殊影响，为研究内皮抑素特异抑制肿瘤组织新生血管的生成提供了实验依据。

Objective: To investigate the possibility of pathologic scars treated in endostatin , by observing the effects of endothelial cell and neogenesis capillary of pathologic scars treated in endostatin , through establishing models of hyperplastic scar in rabbit ear and injecting Endostatin .

目的：建立兔耳增生性瘢痕的动物模型，并采用内皮抑素局部在体干预，观察其对病理性瘢痕新生毛细血管及血管内皮细胞的影响，以探讨内皮抑素防治病理性瘢痕的可行性。

The transter and expression of endostatin gene was analyzed by PCR, the effects of inhibition on proliferation of endothelial cell by endostatin in vitro by MTT method, and the effects on the growth of LoVo、 SGC-7901 in vitro was surveyed, and the growth of expressing endostatin LoVo、SGC-7901 cell line_in subcutaneously of nude mice was also measured.

用MTT法检测内皮抑素对内皮细胞体外增殖的抑制作用，并观察其对LoVo细胞和SGC-7901细胞体外生长的影响，观察表达内皮抑素基因的LoVo和SGC-7901细胞在裸鼠皮下种植的生长。

OBJECTIVE: To observe the inhibitory effects of hAS/293 and hES/293 cells on angiogenesis in chick chorioallantoic membrane.

目的：观察以基因工程技术构建的人血管抑素/293细胞和人内皮抑素/293细胞对鸡胚尿囊膜血管新生的抑制效应。

It was found that after differentiation the cells expressed the endocrine markers insulin 1, glucagons, somatostatin by RT-PCR, however, these endocrine markers cannot be found in uninduced cells.

通过免疫细胞化学染色可以检测到在ICCs中存在有胰岛素、胰高血糖素、生长抑素和pdx-1阳性的细胞，通过RT-PCR可以在mRNA水平检测到胰岛素、胰高血糖素、生长抑素、pdx-1、ABCG2、葡萄糖转运蛋白等的表达。

T739 mice were inoculated with LA795 cells. Angiostatin was given to part of inoculated and uninoculated mice by intraperitoneal injection fourteen days after the inoculation. The treatment lasted 20 days and the size of tumor, survival period, behavior of the mice and pathology of lungs, livers and kidneys were observed.

用亲和层析方法得到的血浆纤维溶酶原经胰蛋白酶消化、层析柱亲和层析、透析，得到纯化的血管抑素；以LA795细胞接种于T739小鼠；接种后第15日起腹腔内注射血管抑素共20 d，观察动物行为，测量荷瘤鼠肿块直径，记录生存期，另设未治疗对照组及观察血管抑素副作用对照组，行肺、肝、肾脏病理学检查。

Methods Affinity chromatography purified plasminogen was digested by pancreatic elastase and angiostatin was obtained by purifying the digestion with affinity chromatography and dialysis. T739 mice were inoculated with LA795 cells. Angiostatin was given to part of inoculated and uninoculated mice by intraperitoneal injection fourteen days after the inoculation. The treatment lasted 20 days and the size of tumor, survival period, behavior of the mice and pathology of lungs, livers and kidneys were observed.

用亲和层析方法得到的血浆纤维溶酶原经胰蛋白酶消化、层析柱亲和层析、透析，得到纯化的血管抑素；以LA795细胞接种于T739小鼠；接种后第15日起腹腔内注射血管抑素共20 d，观察动物行为，测量荷瘤鼠肿块直径，记录生存期，另设未治疗对照组及观察血管抑素副作用对照组，行肺、肝、肾脏病理学检查。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！