抑制神经

The effects, of protection and treatment with, combined Ch, NaF and a trophie were significantly better than that with atropine alone. In isolated phrenic nerve-diaphragm preparation of rat, isolated jejuneal preparation of, guinea pig, and the metabolic experiment of rat liver, the results of the, assay on the rat blood ChE activity indicated that antidotal effect of NaF may be due to the antidese...

大鼠离体膈神经膈肌、豚鼠离体空肠和大鼠肝脏代谢实验及对大鼠全血胆碱酯酶活力测定的结果表明，NaF的抗毒作用可能是由于其对神经肌肉接头和/或神经节中的N受体的抗脱敏作用；而Ch则可能通过其对ChE的保护和/或加速被抑制ChE的复能，阻碍Ach到达M受体部位而发挥作用。

The expression level of metabolitic enzyme (CYP1A1, CYP1B1) and its correlation with cell differentiation /apoptosis were studied as well. The influence of resveratrol in cell cycle was determined with FCM. Results 1 Resveratrol not only suppresses the growth of medulloblastoma cells in a dose and time related fashion but also induces cell differentiation and apoptosis. Resveratrol promotes differention of UW228-1,-2 cells to forward glia, UW228-3 and Med-3 cells to neuron. A treatment of resveratrol in the concentration of 100μM for 48hrs comit most of cells die of apoptosis. 2 Among the four cell lines Fas and Caspase-3 were constantly expessed, whereas FasL was absent irrespective to the drug treatment. 3 ICC, RT-PCR, Western-blot hybridization and EROD enzymatic activity assay demonstrated that expression of CYP1A1 is different after treatment with resveratrol in four cell lines, up-regulated in three UW228 cell lines in a dose dependent manner but down-regulated in Med-3 cells. Suppressive effect of resveratrol on CYP1B1 expression is the same among four medulloblatoma cell lines. 4 Cell cycle distribution of UW228-3 was greatly changed after treatment.

结果：1、白藜芦醇以时间和剂量依赖性方式抑制髓母细胞瘤细胞生长，同时促进细胞的分化和凋亡：白藜芦醇促使UW228-1、-2靶细胞向神经胶质细胞方向成熟分化，UW228-3、Med-3细胞向神经元细胞方向成熟分化，以100μM作用48小时效果显著；2、四个细胞系均有Fas和Caspase-3表达，但无Fas-L基因表达和蛋白活性产生，因此难以形成Fas相关性死亡通路；3、白藜芦醇处理前后CYP1A1基因的表达在各细胞系略有不同：UW228-1，-2，-3三个细胞系白藜芦醇以剂量相关性方式上调CYP1A1的表达，而Med-3细胞系，白藜芦醇却抑制CYP1A1的表达；四个细胞系在白藜芦醇处理后CYP1B1的表达均受到抑制；4、UW228-3细胞系经白藜芦醇作用后细胞周期有较大改变，表现在G0/G1期在整个细胞周期中所占的比例增加，而其它时期则相应减少。

With physiological, pharmacological and biochemical techniques, we studied the mechanisms of hypothalamic stimulation-induced pressor reaction and ventricular extrasystole and the inhibitory effect of deep peroneal nerve input on these neurogenic abnormal cardiovascular activities in order to reveal the regulatory effect of deep somatic nerve input on the cardiovascular activities and explain the mechanisms of the occurrence and cure of some cardiovascular diseases.

本工作采用多学科的实验技术研究了刺激兔下丘脑诱发血压升高和室性期前收缩的发生机制及刺激腓深神经对此神经源性心血管异常活动的抑制机理，旨在揭示躯体深部神经传入冲动对心血管活动的调节作用，并阐明某些心血管疾病的发生和治疗原理。

Neural cell adhesion molecule L1, discovered in the 80s, is one of the matters that can promote nerve regeneration. It can mediate the interaction of cell-to-cell and cell-to-matrix, take great efforts on neurite outgrowth and fasciculation, migration of neural cells, formation of the myelin, structure of neural trace, transmembrane signal transduction, inhibiting apoptosis of neural cells, even on immune system and formation of the tumor. Li is discovered on the mouse's Cerebellar membrane primarily. Thereafter, it also is found in post- mitotic neurons, pre- and non-myelinating Schwann cells and so on.

神经细胞粘附分子L1（L1）是80年代发现的具有促进神经再生作用的物质，它能介导神经细胞与神经细胞之间的粘附，在神经轴突的生长、聚集，神经细胞的转移，纤维髓鞘的形成，神经通路的构建及信号的转导，抑制神经细胞的凋亡甚至在免疫系统、肿瘤的发生等方面均具有非常重要的作用。L1最初是从小鼠的小脑膜中发现，后来发现在有丝分裂后的神经元，髓鞘形成前及非形成髓鞘的雪旺细胞等组织中同样存在。

JuA with the concentrations 0.05g/L and 0.10g/L were tested based on the excitatory effect of 1000KIU/L penicillin and it was found that JuA could inhibit the burst induced by penicillin in CA1 pyramidal cells. Phenobarbital sodium was also applied as apositive control, and the results were in consistent with those reported.

说明青霉素主要通过升高神经组织内的谷氨酸水平破坏神经系统的兴奋和抑制的平衡，而JuA则可以逆转青霉素引起的谷氨酸的升高，在递质的水平起到神经抑制和保护作用。

YIQIHUOXUEFANG can relieve the myelin sheathe swollen of the nerves and the disease of the sciatics, and promote local vessel density around the myelin sheathConclusionsYIQIHUOXUEFANG can regulate blood glucose effectively, improve the mico-circulation around the sciatics of the diabetes rats, restrain the metabolism of the multi-alcohol, increase the expressions of the NGFand MBP, i.e.

益气活血方能有效地调节血糖，改善DM大鼠坐骨神经周围微循环，抑制多元醇代谢，有醛糖还原酶抑制剂样作用，升高Na~+-K~+-ATP酶活性，改善和提高神经传导功能，促进坐骨神经神经生长因子和碱性髓鞘蛋白的表达，可明显缓解DM大鼠周围神经的早期病变，有一定的神经修复作用，综合疗效优于弥可保。

Researchs suggested that ceramide and sphingosine could inhibit mitosis and DNA synthesis of cancer cells, promote apop

细胞水平研究发现神经酰胺和鞘氨醇能抑制结肠癌细胞有丝分裂和DNA合成，促进细胞凋亡，影响Fas、Bcl-2、Bcl-10、bax和P53等凋亡相关蛋白的表达，即神经酰胺和鞘氨醇能通过抑制结肠癌细胞生长、促进细胞凋亡发挥抑癌作用。

Studies also indicated that genistein exsists not only in soybeans but also in many kinds of plants such as vegetables and fruits.As a potential anticancer agent, the actional mechanisms of genistein mainly includes as follows:First, genistein can depress the activity of protein tyrosine kinase and transduction pathways for the phosphorylation of receptors and mitosis signal. So genistein can lead to cells' proliferation depressed. Second, genistein has minimal effects of phytoestrogens. It can be combined with estrogen receptor and improve the synthesis of cellular sex hormone binding glulobin, and improve the activity of UDP-glucuronyl transferase. Through these pathways, it can inhibit the cell activity of breast cancer and prostate cancer.

作为一个很有潜力的抗肿瘤物质，三羟异黄酮的作用机制主要包括：①抑制蛋白酪氨酸激酶活性，可阻抑PTK引起的受体磷酸化和有丝分裂的信号传递，导致癌细胞增殖受抑；②弱雌激素作用：可通过与体内雌激素受体结合，并可增加细胞内性激素结合球蛋白的合成，增加UDP-葡糖醛酸转移酶的活性等途径抑制乳腺癌和前列腺癌细胞活性；③拓扑酶Ⅰ和Ⅱ抑制剂，抑制细胞活性；④上调细胞周期性负性调节因子P21WAF1/CIP1的表达，使之负性调节因子作用增强；⑤可阻止胰岛素样生长因子-Ⅰ、肝细胞生长因子和神经生长因子的作用而抑制肿瘤生长；⑥其他：抗氧化作用、抑制热休克蛋白、诱导细胞凋亡、抑制新生血管生成和抑制多种耐药相关蛋白等。

Median nerve or deep peroneal nerve stimulation could inhibit completely or partially the deflection of ischemic ECG ST segment due to stimulation of dorsomedial hypothalamic nucleus.

电刺激正中神经和腓深神经均能抑制或部分抑制下丘脑背内侧核诱发的缺血性心电ST段偏移，以刺激MN更为明显。

Furthermore,MH shortenmolting period and accelerating the gonadial development.This is the major causegiving rise to precocious mature in the cultured chinese mitten crab.Keywords:Eriocheirsinensis Precocious crab Culture Ultrastructure Cell

体内高浓度的胆固醇通过抑制眼柄神经分泌细胞抑制性神经肽激素的合成和释放，促进Y-器官合成和释放MH，缩短养殖河蟹的蜕皮周期，加速了河蟹的性腺发育，造成养殖河蟹性早熟。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。