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The colon temperatures were measured by a thermistor and the cytosolic free calcium concentration ([Ca2+]i) in dissociated brain cells was measured by Fura 2-AM. The results demonstrated that the pyretic action of egtazic acid (0.6 μmol, icv) was markedly inhibited by DEX (5 mg/kg,iv), but DEX (60-120 μmol/L) did′t affect [Ca2+]i in dissociated hypothalamus cells. Actinomycin D, which interferes with gene transcription (3 nmol, icv), completely abolished the antipyretic action of DEX on egtazic acid-induced fever.

结果发现:脑室灌注乙二醇双(2-氨基乙醚)四乙酸(0.6 nmol)引起家兔结肠温度明显升高,静脉注射地塞米松(5 mg/kg)显著抑制家兔乙二醇双(2-氨基乙醚)四乙酸性发热,地塞米松(60-120 μmol/L)并不影响下丘脑细胞内[Ca2+]i,而事先脑室灌注抑制基因转录的放线菌素D(3 nmol)则完全取消了地塞米松对乙二醇双(2-氨基乙醚)四乙酸性发热的解热作用。

Methods:Alpha-glucosidase activities were examined with or without Folium Mori alkaloids extract,Ramulus Mori extract and acarbosein vitro, and the IC_(50)were calculated.

本文以拜糖平为阳性对照,采用α-葡萄糖苷酶体外抑制作用实验,比较了桑叶生物碱浸膏、市售的桑枝提取物以及拜糖平对α-葡萄糖苷酶的抑制作用能力差异。

Simvastatin may suppress interstitial fibrosis by effect CTGF、suppress cell proliferation、redue extracellular matrix accumulation.

辛伐他汀可以抑制CTGF、抑制肾小管上皮细胞的转分化、减轻细胞外基质的积聚,从而减轻间质纤维化,发挥肾保护作用。

ResultsLoureirin B inhibits the TTXR peak sodium currents in a dose-dependent model and the inhibition is reversible. 0.2mmol/L loureirin B accelerates the inactive process of the TTXR sodium currents and delays the revivable process but does not affect the activitive process.

结果龙血素B对TTXR钠电流呈浓度依赖性抑制,且抑制作用可逆;高浓度的龙血素B(0.2 mmol/L)加速TTX-R钠通道电流的失活过程,延迟其复活过程,对激活过程无显著影响。

ResultsLoureirin B inhibits the TTXR peak sodium currents in a dose-dependent model and the inhibition is reversible. 0.2mmol/L loureirin B accelerates the inactive process of the TTXR sodium currents and delays the revivable process but does not affect the activitive process.

结果龙血素B对TTXR钠电流呈浓度依靠性抑制,且抑制作用可逆;高浓度的龙血素B(0.2 mmol/L)加速TTX-R钠通道电流的失活过程,延迟其复活过程,对激活过程无显著影响。

rutaecarpine pharmacological effects and its related mechanism: rutaecarpine the heart positive inotropic, positive changes in the role and the heart protective effect, which with its promotion of calcitonin gene-related peptide release; rutaecarpine alkali have vasodilative and hypotensive effect, its mechanism mainly related to endothelial cells Ca2 +-NO-cGMP pathways and calcitonin gene-related peptide release; rutaecarpine to relax the anal sphincter, gastrointestinal motility inhibition of stress ulcer and ulcerative colitis have therapeutic effect; rutaecarpine on cerebral ischemia-reperfusion injury has a protective effect, which instead of increasing the concentration of calcitonin gene-related peptide-related; rutaecarpine inhibits platelet aggregation and arterial thrombosis; In addition, rutaecarpine Alkali also anti-inflammatory and analgesic, anti-tumor and other pharmacological effects.

综述了吴茱萸次碱的药理作用及其相关机制:吴茱萸次碱对心脏有正性肌力、正性变时作用和心脏保护作用,这与其促进降钙素基因相关肽释放有关;吴茱萸次碱有扩血管和降压作用,其机制主要涉及内皮细胞Ca2+-NO-cGMP途径和降钙素基因相关肽的释放;吴茱萸次碱能松弛肛门内括约肌,抑制胃肠运动,对应激性溃疡和溃疡性结肠炎也有治疗作用;吴茱萸次碱对脑缺血再灌注损伤有保护作用,这与其增加降钙素基因相关肽浓度有关;吴茱萸次碱能抑制血小板聚集和动脉血栓形成;此外,吴茱萸次碱还有抗炎镇痛、抗肿瘤等药理作用。

Additionally, the water fraction from wood extract can inhibit the root growth on Pak-choi. At 1000 μg/mL, after 72 h, the length ratio of root to shoot was 0.69, and the dry weight of Pak-choi root was only the 20.6% of control. But the extracts of Sapindus mukorossi have no influence on the growth of Pak-choi with normal growth 7 days.

此外,木材抽出物之水分离部则具有抑制胚根生长的作用,经浓度1,000 μg/mL处理72 h之小白菜,胚根与胚茎长比值为0.69,且其胚根乾重仅为对照组的20.6%,但无患子抽出物对正常生长7天后之小白菜并无显著抑制生长作用。

Furthermore, the control efficacy of the extract product of mycelium and the fermentation extraction were all 100% against Sclerotinia sclerotiorum under the concentration of 10 mg/mL.

菌丝生长速率法试验结果表明,在1 mg/mL浓度下,菌体提取液对8种供试植物病原真菌的菌丝生长抑制率大于90 %;发酵液提取物对11种供试植物病原真菌的菌丝生长抑制率大于90 %。

The compounds Ⅲ and Ⅲ have good fungicidal activity to Sclerotinia sclerotiorum and Rhizoctonia solani, and their inhibition ratios are 40.4% and 51.6%, respectively.

其中化合物Ⅲ和Ⅲ分别对油菜菌核病菌和水稻纹枯病菌有较强的抑制活性,抑制率分别为40.4%和51.6%,而Ⅲ的抑菌活性较弱。

The compounds Ⅲa and Ⅲb have good fungicidal activity to Sclerotinia sclerotiorum and Rhizoctonia solani, and their inhibition ratios are 40.4% and 51.6%, respectively.

其中化合物Ⅲa和Ⅲb分别对油菜菌核病菌和水稻纹枯病菌有较强的抑制活性,抑制率分别为40.4%和51.6%,而Ⅲf的抑菌活性较弱。

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According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm~150rpm时取得最大值,此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世,形体几无变化。

When I was in school, the rabbi explained everythingin the Bible two different ways.

当我上学的时候,老师解释《圣经》用两种不同的方法。