抑制的

The expression level of metabolitic enzyme (CYP1A1, CYP1B1) and its correlation with cell differentiation /apoptosis were studied as well. The influence of resveratrol in cell cycle was determined with FCM. Results 1 Resveratrol not only suppresses the growth of medulloblastoma cells in a dose and time related fashion but also induces cell differentiation and apoptosis. Resveratrol promotes differention of UW228-1,-2 cells to forward glia, UW228-3 and Med-3 cells to neuron. A treatment of resveratrol in the concentration of 100μM for 48hrs comit most of cells die of apoptosis. 2 Among the four cell lines Fas and Caspase-3 were constantly expessed, whereas FasL was absent irrespective to the drug treatment. 3 ICC, RT-PCR, Western-blot hybridization and EROD enzymatic activity assay demonstrated that expression of CYP1A1 is different after treatment with resveratrol in four cell lines, up-regulated in three UW228 cell lines in a dose dependent manner but down-regulated in Med-3 cells. Suppressive effect of resveratrol on CYP1B1 expression is the same among four medulloblatoma cell lines. 4 Cell cycle distribution of UW228-3 was greatly changed after treatment.

结果：1、白藜芦醇以时间和剂量依赖性方式抑制髓母细胞瘤细胞生长，同时促进细胞的分化和凋亡：白藜芦醇促使UW228-1、-2靶细胞向神经胶质细胞方向成熟分化，UW228-3、Med-3细胞向神经元细胞方向成熟分化，以100μM作用48小时效果显著；2、四个细胞系均有Fas和Caspase-3表达，但无Fas-L基因表达和蛋白活性产生，因此难以形成Fas相关性死亡通路；3、白藜芦醇处理前后CYP1A1基因的表达在各细胞系略有不同：UW228-1，-2，-3三个细胞系白藜芦醇以剂量相关性方式上调CYP1A1的表达，而Med-3细胞系，白藜芦醇却抑制CYP1A1的表达；四个细胞系在白藜芦醇处理后CYP1B1的表达均受到抑制；4、UW228-3细胞系经白藜芦醇作用后细胞周期有较大改变，表现在G0/G1期在整个细胞周期中所占的比例增加，而其它时期则相应减少。

Catalytic autoxidation of AA was inhibited by stable Cuamino acid complexes; histidine, having the highest conditional stability constant for its Cu-complex, showed the strongest inhibitive effect.

稳定之含铜氨基酸复合物会抑制抗坏血酸之自氧化；组氨酸对铜离子复合物有很高的稳定性，且具有很强之抑制作用。

Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞，导致细胞生长的抑制和凋亡罗伯托利，斯特凡Purgato ，苏埃洛卡默琳，拉菲尔Fronza ，梅奥尼博洛尼亚，西蒙娜Alboresi ，莫妮卡弗兰索尼，罗伯托Corradini ，斯特凡诺斯福尔扎，安德烈Faccini ，杰森先生Shohet ， Rosangela Marchelli ，和安德烈Pession儿科，博洛尼亚大学，圣' Orsola -马尔皮基医院，博洛尼亚，意大利；有机部和工业大学化学帕尔马，帕尔马，意大利和3Center的细胞和基因治疗，德州儿童癌症中心， Baylor医学院，得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞，针对一个独特的序列反义DNA链的第2外显子，并与在MYCN 其氨基端为核定位信号肽。

All the contents of Extractable heavy metal like Pb, Cu, Zn and Cd in limestone slagged wasteland are higher than those in contrapositive soil nearby. The slag filtrate has no effect on seed germination rate of Mung beans, Broad beans and Corns but restrains their germination vigor and protraction of hypocotyls with root restraint rate exceeding 30-50%; While it has an apparent effect on germination rate and germination vigor of sensitive seeds like Beans with P=0.05. Simulate to plant the 4 different seeds in pot for a month, Test groups have a lower data in total leaf area, plant height and weight but a much higher content of protective materials like PRO and MDA in biochemical mensuration experiment compared with CK group.

石灰炉渣废弃地中Pb、Cu、Zn、Cd重金属有效态含量均高于临近对照土壤，其炉渣淋出液对绿豆、蚕豆、玉米3种植物种子发芽率无影响，但均抑制其发芽势和下胚轴伸长，根长抑制率达30%~50%以上，对敏感种子黄豆的发芽率、发芽势（4d）影响明显，摸拟盆栽一个月苗期，4种植物试验组在总叶面积、株高、生物量方面均低于对照组；生理生化测定，4种植物其体内抗逆性保护物质脯氨酸和膜过氧化产物丙二醛含量试验组均高于对照组。

In this method, we use the pooled correlogram based on human auditory model to extract the pitch of speech. An unsupervised lateral inhibitory network is used to get the peak position, which simulates the lateral inhibitory phenomenon in human auditory system.

采用基于人耳听觉模型的相关图来提取语音信号的基频，运用无监督的侧抑制神经网络来模拟人耳侧抑制属性进行基频检测，为了克服在低信噪比情况下侧抑制神经网络的误判问题，引入了相邻语音帧的语音基频的帧间约束。

The X-ray crystallography of the KARI enzyme, inhibitors and their inhibit mechanism, and theoretical research are reviewed.

本文综述了KARI的酶学、KARI抑制剂及其抑制机理和理论研究进展，并对其发展趋势进行了展望。

On days 7, 8 and 9, a highly level of COX-2 immunostaining was seen in primary decidua.

与对照组相比，两种抑制剂都能够抑制24日龄大鼠和性成熟大鼠的排卵。

The erigeron extract inhibits maturation and function of dendritic cells in peripheral blood following renal transplantation with a dose-dependent manner.

灯盏花提取物能抑制大鼠肾移植后外周血中树突状细胞的成熟和功能，随剂量加大，抑制作用增强。

The effects on mouse's ileum can totally been inhibited by atropine, eserine, fugutoxin, and morphine.

对小鼠回肠的作用可完全被阿托品抑制，或被毒扁豆碱、河豚毒素或吗啡抑制。

Crescent euphorbia can inhibit the growth of Lewis lung cancer, no side effection of the mices blood system was found,the underlying mechanism of which was associated with induction of apoptosis and inhibition on cancer cells.

猫眼草可抑制Lewis肺癌生长，对小鼠血液系统无明显毒副作用，其抗肿瘤作用与诱导细胞凋亡及引起肿瘤细胞的生长抑制有关。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。