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To continue the previous work from our laboratory, the purpose of this study is to investigate IGFBP-5 gene expression by BP and ripen areca nut extract in NHOKs . The results in this study suggest that BP and rANE exhibited inhibition effects on IGFBP-5 gene expression both on transcription and translation levels in NHOKs .

本研究发现, BP 及老槟榔萃取物对於正常口腔角质细胞中 IGFBP-5基因之表现均有抑制之效果,且此抑制效果不但发生於基因转录阶段,甚至还持续到转译阶段;类似的结果也在 SCC25细胞中观察到。

By density functional theory B3LYP method with 6-31G basis set, the geometry and electronic structure of the natural inhibitor and derivatives of Adenylosuccinate synthetase were optimized and their thermodynamic stability was also analyzed. The relationship between their electronic structures and bioactivities were discussed based on the Mulliken bond order, atomic net charge distribution and molecular surface electrostatic potential.

利用密度泛函B3LYP方法选择6-31G基组对腺苷酸琥珀酸合成酶天然抑制剂及其衍生物的结构进行优化,并对其稳定性进行了分析,同时采用Mulliken键序、原子电荷分布、表观静电势等对AdSS抑制剂及其衍生物电子结构与其生物活性相关性进行了理论研究。

It is also a performance measurement of a suppressor's ability to attenuate a transient.

Vc也是用来测定瞬态电压抑制二极管在抑制瞬态电压时的性能。

The bacteriostatic experiment showed that 13 strains had antifungi activity and 2 strains had resistant gram-positive bacteria.

抑菌实验表明,携带KS基因的16株放线菌中,13株具有抑制真菌活性,2株具有抑制革兰民阳性细菌活性。

Effect of drugs on invasion and migration of LS174T cells was observed in reconstructed basement membrane invading experiment.

主要观察指标:N-硝基精氨酸甲酯对LS174T细胞侵袭重建基底膜的抑制率和趋化运动抑制率。

The bacteriostatic effects, action mechanisms and antimicrobial spectrum of the strains were tested. After 5 days of culture, a bacteriostatic belt of 6.9-9.67 mm in width was observed on the culture plate, and the inhibitory activity maintained for 10 d. Prefiltration fermentation of the strains P1 and P5 could significantly inhibit conidial germination of the pathogen, with inhibitive rate ranging from 97.51% to 98.12%. The action might be realized by inducing hyphal deformity, bioplasm concentration, conidial germination inhibition and distorting germ tubes of conidia.

通过对其抑菌效果、机制和抗真菌谱进行测定,结果表明,P1、P5和葡萄灰霉病菌对峙培养5 d后,均产生明显的抑菌带,抑菌带宽度为6.90~9.67 mm,培养10 d后,仍然保持稳定的抑菌效果;P1、P5的发酵原液对葡萄灰霉病菌孢子萌发具有显著的抑制作用,抑制率为97.51%~98.12%;P1、P5对病菌的作用机制表现为使病菌菌丝畸形、原生质浓缩、菌丝断裂、抑制病菌分生孢子的萌发、导致孢子芽管扭曲。

The colony forming and the cell cycle were analyzed with flow cytometry, and the mRNA expression of bcl-2, c-myc gene were determined with RT-PCR method. Results Resveratrol could markedly inhibit proliferation of human gastric cancer cells compared with that of the blank control group. The cell cycle was blocked to G0/G1. The mRNA level of bcl-2 and c-myc gene were decreased compared with that of the blank control group.

结果 白藜芦醇可抑制胃癌细胞增殖和集落形成能力,低、高剂量组的抑制率分别为6.9%,17.6%和27.98%,63.39%,差异均有统计学意义(P.05);白藜芦醇能使胃癌细胞周期阻滞于G0/G1期,明显下调胃癌细胞bcl-2、c-myc基因mRNA表达水平(P.05);用药24 h后,白藜芦醇高剂量组bcl-2和c-myc基因相对表达量分别为(0.54±0.04),(0.58±0.05),与空白对照组(0.91±0.05),(0.85±0.03)比较,差异均有统计学意义(P.05)。

The inhabiting effect was dose dependent.[Conclusion]Alendronate has the inhabiting effects of oil bone resorption and the differentiation of bone marrow cells into osteoclast-like cells in vitro.

结论]阿伦膦酸钠可抑制骨髓细胞体外培养中破骨样细胞的形成,体外可抑制破骨细胞骨吸收作用。

Methods The mice were given the meloxican tablet, ig, at the dosage of 0.56,1.13,2.25 and 9.00 mg.kg-1, then ip 0.8%acetic acid, and injecting the ear of mice. The meloxicans were given to rats, at the dosage of 1.5,3.0,6.0 mg.kg-1, to observe the effect of the meloxican inhibiting the paws swelling of rats by carrageen and granulation of rats by paper method.

观察美洛昔康对醋酸导致小鼠血管通透性增加和二甲苯引起小鼠耳肿胀抑制作用,以及角叉菜胶诱发大鼠足肿胀和纸片法引起大鼠肉芽增生的抑制作用。

The assay of DPPH free radical clean test best is Cissus pteroclada, it has over 95%, in anti-liver lipid peroxidation assay, the best is Ampelopsis cantoniensis, it has over 95% too, and Ampelopsis Japonica has well effect on killing human breast cancer cells MCF-7 but have no effect about anti-oxidation.

抗肝脂质过氧化试验中以广东山葡萄最好,其抑制率有95%以上。白蘝对於抗氧化虽然无特别效用,但在人类乳癌细胞株MCF-7毒杀试验上有很好的成效其抑制细胞生长率为95%以上。

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According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm~150rpm时取得最大值,此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世,形体几无变化。

When I was in school, the rabbi explained everythingin the Bible two different ways.

当我上学的时候,老师解释《圣经》用两种不同的方法。