抑制的

It was known that pyridine and Triton-x100 had a bad effect on the cell growth and lycopene production were studied. The results indicated that pyridine and triton-x100 inhibited cell growth and lycopene synthesis;β-ionone increased cell growth and lycopene synthesis when the concentration was 0.05 ml/L, but when the concentration became higher, there would be a decrease on the lycopene output; span-20 increased cell growth and lycopene synthesis effectively when the concentration reached 2.0ml/L, and the lycopene yield became 2.4×10~(-2) mg/L which was 3-fold than control.

研究了培养基中加入不同浓度的小分子效应物吡啶、Triton-x100、Span-20、β-紫罗酮、异烟肼对番茄红素产量的提高作用，结果显示培养基中加入很低浓度的吡啶(0.1ml／L)就会对菌体产生很强的毒害作用；triton-x100对类胡萝卜素的合成也有很强的抑制作用，试验的浓度为0.2ml／L到5ml／L，结果发现它对菌体的生长和番茄红素的合成都有抑制作用；β-紫罗酮在浓度为0.05ml／L时有很小的促进作用，而浓度升高就有了比较强的抑制效果；span-20在液体培养基中的加量为2.0ml／L时，对番茄红素的合成有很强的促进效果，产量达到了2.4×10~(-2)mg／L，比原始菌株产量提高了2倍，而浓度进一步增大就产生了很强的抑制效果。

The study showed the recombinant wt/mCREG protein depressed the VSMC proliferation depending on dose and the optimal concentration was 400nM;2biologic function of CREG protein and the membrance receptor mechanism:①effect on VSMC migration: the wound healing experiment showed the OB2 cells migration was slower significantly after added wt/mCREG(400Nm) in supernatant. The HITASY cells migration were very slowly and no remarkable change. The gelatinase digestion and Western blot analysis showed the matrix metalloproteinase was decreased and TIMPs was increased;②effect on differentiation: after added wt/mCREG(400nM), the expression of myocardin, SMα-actin, MHC and caldesmin were increased and that of LM-1 and FN were decreased in OB2 cells. These effects were more significant when adding wtCREG.;③effect on VSMC proliferation: Cell cycle assay and BrDU stain showed: after added the wtCREG and mCREG protein, the ratio of cell in G0/G1 phase increased to 0.5773 and 0.5572 from 0.5308 respectively in OB2 group, which increased to 0.7369 and 0.7034 respectively from 0.6297 in HITASY group;3Role of M6P/IGF2R in CREG biologic function:①ELISA and co-immunoprecipitation showed the wt/mCREG binding to M6P/IGF2R directly.②antibody blocking test: when the anti-IGF2R was added to medium at the same time with wt/mCREG at different concentration(2μg/mL、4μg/mL、8μg/mL),the effects of CREG protein which depressing proliferation, migration, secretion and promoting differentiation were blocked, which had the positive correlation to the concentration of added anti body. The studies showed two combinant CREG promoted VSMC switch to differentiation phaenotype, at the same time, depress VSMC proliferation, migration and secreting extracellular matrix.

上述实验结果证实：两种重组CREG蛋白对VSMC增殖均有剂量依赖性的抑制作用，并且相同浓度的糖基化的CREG蛋白对细胞增殖的抑制效应更为显著，最佳效应浓度为400nM；2两种重组CREG蛋白添加后对HITASY和OB2细胞生物学行为的影响：①CREG蛋白对VSMC迁移的影响：刮伤实验发现，加入最佳效应浓度的wtCREG和mCREG蛋白24h后，OB2组迁移能力下降，HITASY组无明显变化；细胞外基质金属蛋白酶-2，9(Matrix metallo-proteinase 2，9，MMP2 ，9)明胶酶电泳检测和Western blot检测结果证实，两种CREG蛋白均可以使OB2细胞合成细胞外基质MMP2，9减少，而组织金属蛋白酶抑制物(Tissue Inhibitors of Metalloproteinases，TIMPs)增加；②CREG蛋白对VSMC分化的影响：加入400nM的wtCREG和mCREG蛋白12h后，OB2细胞myocardin、SMα-actin、MHC、caldesmin表达增加，LM-1、FN表达减少；③流式细胞仪分析细胞周期和BrDU染色分析证实，加入400nM的wtCREG和mCREG蛋白后，OB2组G0/G1期细胞由0.5308分别增加至0.5773和0.5572，HITASY组G0/G1期细胞由0.6297分别增加至0.7369和0.7034；3M6P/IGF2R在重组CREG蛋白的生物学功能中的调控作用：①免疫共沉淀和免疫荧光双染色分析结果显示，CREG蛋白与M6P/IGF2R存在直接结合；②应用抗体阻断实验：将不同浓度的anti- M6P/IGF2R(2、4、8μg /mL)与两种CREG蛋白同时加入培养液中，CREG蛋白抑制VSMC增值、迁移和合成细胞外基质、促进分化的效应减弱，而且与加入anti- M6P/IGF2R浓度正相关。

The balanced bilingualism's conflicts control ability are better than the unbalanced bilingualisms' at levels of response activation in the interference condition of Chinese color words; the balanced bilingualism and the unbalanced bilingualism have the same conflicts control ability at the levels of perceptual processing in the interference condition of Chinese color words; The balanced bilingualism's conflicts control ability are better than the unbalanced bilingualisms' at levels of perceptual processing in the interference condition of English color words; the balanced bilingualism and the unbalanced bilingualism have the same conflicts control ability at the levels of response activation in the interference condition of English color words.

在中文色词干扰条件下，在心理加工的知觉阶段，熟练双语者和不熟练双语者的抑制控制能力没有差异；在心理加工的反应阶段，熟练双语者的双语抑制控制能力明显强于不熟练双语者；在英文色词干扰条件下，在心理加工的知觉阶段，熟练双语者的双语抑制控制能力明显强于不熟练双语者；在心理加工的反应阶段，熟练双语者和不熟练双语者的抑制控制能力没有差异。

Potassium channel blockers(TEA10mmol/L and 4-AP10mmol/L) partly reduced the majority of outward current to 23.4±2.4%.(2)Bath application of Cl—-free Ringer's solution and potassium channel blockers(TEA10mmol/L and 4-AP10mmol/L) could almost completely block the outward current, only remaining 2.2±0.2%.

该电流被最大抑制剂量的钾离子通道拮抗剂TEA(10mmol/L)和4-AP(10mmol/L)协同作用时，只能被抑制到最大电流幅度的23.4±2.4%；(2)用无氯Ringer氏液与钾离子通道拮抗剂(TEA10mmol/L和4-AP10mmol/L)协同作用时，可将此电流基本抑制，仅剩2.2±0.2%。

TCM may modulate the glial cells through the following mechanisms: inhibiting expression of iNOS, thereby minishing the toxicity of NO and its oxygen free radicals; inhibiting overactivation of astrocytes and overexpression of GFAP in acute cerebral ischemia and cerebral hemorrhage; promoting glial cells' secretion of NGF which can be caused by ischemic injury; inhibiting the nervous system's immune inflammatory response; and so on.

中药调节神经胶质细胞活性的机制可能包括：（1）抑制iNOS表达，从而抑制NO及其产生的氧自由基的毒性；（2 抑制脑缺血和脑出血急性期星形胶质细胞的过度活化和GFAP的过度表达；(3)上调缺血损伤导致的神经胶质细胞分泌NGF；(4)抑制神经系统的免疫炎症反应等各种途径。

MCP could effectively delay the softening of climacteric fruit, such as Starking and Fuji apples and Feicheng peach, but as different fruits had different softening mechanism, the mechanism of 1-MCP inhibiting different fruit softening was different: in Starking apples, the key enzyme to the softening is endo-and exo-PG, while during Feicheng peach fruit softening, the key enzyme was EGase before the 20th d and endo-PG after 20th d during storage at 0℃. 1-MCP inhibited fruit softening mainly by inhibiting PG activity in Starking apple while in Feicheng peach, by inhibiting the activity of EGase in the earlier storage time and endo-PG in the latter time. It was also found that LOX accelerated the initiation of the softening and was regulated by ethylene and 1-MCP in apple and peach.

2.1-MCP能较好的延缓红星、富士和肥城桃等跃变型果实硬度的下降，但是不同品种/树种的果实软化机理不同，1-MCP抑制其软化的机理也不一致：在红星果实中，对软化起主要作用的酶一直为内切和外切两种PG，而在肥城桃软化过程中，前20d以纤维素酶活性起主要作用，20d后软化以内切PG为主。1-MCP主要通过抑制红星果实中PG酶活性来抑制果实硬度的下降；在肥城桃果实中，1-MCP通过抑制前期纤维素酶和后期内切PG活性，延缓了果实硬度的下降。

HASMCs of control (with old HS stored at 4℃ for 2 years) shrank and showed poor-growth pattern while those in groups of different concentrations of LMWH or heparin became well-spread and well-growth pattern.

结果发现，肝素及小肝素分子对生长良好的平滑肌细胞有抑制作用，不同浓度肝素的抑制率分别为66％、69％和69％，而不同浓度小肝素分子抑制率分别为60％、68％和67％。

When heavy load is transmitted along a 750 kV transmission line, the connected shunt reactors can lead to big voltage decreasing, so transmitting capacity of line is limited greatly.

为解决线路传输能力与抑制过电压的矛盾，分析研究了并联电抗器在抑制750kV线路跳闸过电压、加速潜供电弧熄灭以及抑制合闸过电压等方面的作用，并由此提出了750kV线路保护与并联电抗器之间动作配合关系。

Results: 1st, through the method of the mouse ear swelling as well as chemical stimulations analgesia experimental method and hot plates analgesia experimental technique the hotplate method experiment, had proven the treatment law of removing blood stasis and dredging collateral of the acupuncture and moxibustion to have the obvious effect of anti-inflammation and analgesic p

1、针灸化瘀通络法抗炎镇痛效果明显，抗炎作用可能主要与抑制细胞因子释放有关，而镇痛作用可能主要与抑制外周K~+、NE、DA和5-HT释放有关。2、针灸化瘀通络法有抑制XOD的活性，减少尿酸生成和促进尿酸排泄的作用。

This article focused on the mechanisms, characteristics, and associated assays used to identify these proteins, and the prospects of those suppressors were also discussed.

论述了主要沉默抑制因子的机制、特点和相关确认沉默抑制因子实验，并对沉默抑制因子的研究前景进行了展望。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。