抑制的

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗(来源：A44B8787C论文网www.abclunwen.com)功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

Secondly, this paper describes the effect of presence of inorganic salts namely, sodium chloride, sodium sulphate, sodium nitrate, sodium dihydrogen phosphateand and sodium bicarbonate on decolouration of azoic dye effluents by the UV-Vis /Ferrioxalate/H2O2 process.

本课题可以得到以下结论：在偶氮染料光催化氧化脱色反应中，无机盐有抑制作用，并且依其种类不同，其抑制作用亦有差异；表面活性剂对于染料的脱色降解存在不同程度上的抑制作用。

4 Had the most intensive herbicidal activity. The inhibiting rate of No. 4 was 95.8%, 93.76% and 86.36% against the taproot ,caulis and the bourgeon of retroflexus L. respectively.

经HPLC分离后得到8个馏份，其中馏份4的除草活性最强，对反枝苋的种子萌发抑制率为86.36%，主根生长抑制率为95.84%，主茎生长抑制率为93.76%。

In T cells,TGF-beta1 can inhibit their proliferation,inhibit the differentiation of Th1 and Th2,inhibit the differentiation of CTL,induce the generation of regulatory T cellsTregin B cells,TGF-beta1 can inhibit their proliferation,induce IgA class switch,it also can induce the apoptosis of immature and resting B cells;in NK cells,TGF-beta1 can inhibit the secretion of IFN-γand the cytolytic function of NK cells.

对T细胞，TGF-beta1可以抑制其增殖，抑制Th1和Th2细胞的分化，抑制CTL的分化，诱导调节性T细胞的产生；对B细胞，TGF-beta1可以抑制B细胞的增殖，诱导IgA的类别转换，还可以诱导不成熟和静息B细胞的凋亡。

The resistance to oxidation of synthetical ferulaic acid glycolipide was investigated. The result was shown, apple was dipped in 0.62% ferulaic acid glycolipide, the most inhibitor effectiveness of glucose ferulaic esters and xylose ferulaic ester was shown respectively to be 36.92% after four days and 19.47% after eight days, the fastigium of release ethane was postponed respectively to be six days and four days.

本文测定了合成阿魏酸糖脂的抗氧化性，结果表明用0.62％的阿魏酸糖脂浸泡的苹果，阿魏酸葡糖酯抑制效应在处理后4天最明显，抑制率 36.92%，阿魏酸木糖酯抑制效应在处理后8天最明显，抑制率为 19.47%对于果实的内源乙烯释放，经阿魏酸葡糖酯和阿魏酸木糖酯处理的苹果分别推迟乙烯释放高峰期6天和4天。

The results showed that TNF-α effectively inhibited preadipocyte proliferation stimulated by insulin and decreased lipogenesis through inhibiting stimulation of insulin on transcriptional expressions of lipogenic genes such as acetyl-CoA carboxylase α(ACC1), fatty acid synthase, sterol regulatory element binding protein-1c in adipocytes, suggesting that TNF-α is a effective inhibitor of adipogenesis in adipose tissue.

结果表明，TNF-α可有效抑制胰岛素对原代培养大鼠前体脂肪细胞增殖的促进作用，并通过抑制胰岛素对转录因子SREBP-1c和脂肪酸合酶FAS及ACC1基因转录表达的促进作用，减少脂肪酸的生物合成，抑制成熟脂肪细胞的脂肪生成，证明TNF-α是动物脂肪形成的有效抑制因子。

The EC_(50) of QKL against the formation of syncytia of MT-2 induced by HIV-1_ was 1/198.02 with a SI of 5.36. By detecting the survival rate of co-culturing H9/HIV-1_ cells and MT-2 cells or MT-2 cell direct infected by HIV-1_ QKL was found to be protective to cells. The EC_(50) was 1/166.67 and 1/144.93 with SI of 4.51 and 3.92 respectively. The EC_(50) of QKL against P24 antigen production was 1/175.44 with SI of 4.75. The drug serum of QKL was also found to be effective to inhibit the cell fusion and protect cells infected by HIV-1_.

结果：QKL对H9／HIV-1_细胞和MT-2细胞的CC_(50)分别为1／50.76和1／36.97；抑制H9／HIV-1_细胞和MT-2细胞早期融合的EC_(50)=1／235.29，SI=6.36；抑制HIV-1_细胞诱导MT-2细胞形成合胞体的EC_(50)=1／198.02，SI=5.36；H9／HIV-1_细胞和MT-2细胞混合培养和HIV-1_感染MT-2细胞时，QKL保护病毒感染细胞免于死亡的EC_(50)分别为1／166.67和1／144.93，SI分别为4.51和3.92；抑制p24抗原产生的EC_(50)=1／175.44，SI=4.75；QKL药物血清也可抑制H9／HIV-1_细胞和MT-2细胞的早期融合，保护细胞免于死亡。

The results suggest that there is prominent short-term synaptic depression in the rat thalamocortical visual pathway. Presynaptic transmitter depletion and postsynaptic GABAergic inhibition are the main possible mechanisms of this synaptic depression. The short-term synaptic depression is helpful in neuronal correlated firing detection.

以上结果表明：丘脑皮层视觉通路具有显著的短时程突触抑制特性，突触前的递质耗竭和突触后的GABA能抑制系统很可能是产生视通路短时程突触抑制作用的主要机制，突触抑制作用有助于视觉系统对同步发放活动的检测。

Baicalin could inhibit the initial-period and mid-period activation of mouse T lymphocytes stimulated by Con A or PDB,which suggests that baicalin have the inhibitory effect on signaling pathway of T lymphocytes activation and be a potential effective immunoinhibitory agent.

结论黄芩苷能够明显抑制多克隆刺激剂Con A或PDB诱导的T细胞早期和中期活化，且呈明显的量效关系。提示黄芩苷在T细胞活化过程的信号转导中有抑制作用，从而可以通过抑制T淋巴细胞的活化，发挥免疫抑制作用，是一种潜在的免疫抑制剂。

According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm～150rpm时取得最大值，此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世，形体几无变化。