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GnRH could mar Red I y suppress progesterone secretion of cultured GCs with or without FSH and LH co-treatments. E2 could invert the suppression of GnRH completely, also had the additive action on secreting progesterone with GnRH co-treatment. Mel partial ly released the suppression action of GnRH.

GnRH能强烈地抑制体外培养的颗粒细胞分泌孕酮,其抑制作用几乎不受FSH和LH影响;Mel仅表现部分地缓解了GnRH的抑制效应,但没有逆转。E_2不仅可以完全逆转GnRH的抑制作用,进而与GnRH叠加促进颗粒细胞分泌孕酮。

So worked resistance decrease of grafted cucumber.Grafted cucumber and squash root exudates have the inhibitory effect of germination of cucumber, elongation of root and hypocotyls, and have the same effect on squash.

南瓜和嫁接黄瓜根系分泌物对黄瓜发芽率,胚根胚轴的伸长均具有明显的抑制作用,这种抑制效果与浓度呈正相关;对南瓜发芽率及其胚根胚轴伸长的抑制也达到显著水平,这种抑制效果与浓度同样呈正相关。

In addition, the maximum velocity in larvae was significant higher than those in pupae and adults. In vitro inhibition studies of larvae AChE indicated that the I50 values of 20-d larvae were higher than those of 10-d larvae when treated with eserine, malaoxon and carbaryl, respectively, suggesting that AChE in 20-d larvae was less sensitive to the inhibitors.

通过对幼虫AChE离体抑制作用测定表明,毒扁豆碱、马拉氧磷和西维因对20d龄幼虫的抑制中浓度I50均高于10d龄幼虫,说明20d龄幼虫体内的AChE对3种抑制剂的抑制作用更不敏感。

Parthenolide is extract from feverfew, it's main component is sesquiterpene, it is commanly used in west country and is mainly used to therapy skin infection, rheumatic disorder, migraine. But recent research indicate that parthenolide can regulate many pathway of signal in the cell, inhibit the cyclooxygenase, TNF-α, interleukin-1 expression induced by lipopolysaccharide in macrophage, inhibit the iNOS expression in human monocyt, inhibit the activity of NF-κB in Hela cell, inhibit the growth of tumor cell and can relieve the myocardial ischemical reperfusion injury and so on. But the invention research about the effection of parthenolide on the VSMC is very rare in the world, so we do some research about the effection of inhibition of parthenpolide on the proliferation of VSMC and the signal transduction mechanism.

小白菊内酯(parthenolide,又名Sesquiterpene lactone)是艾叶菊属黑叶母菊的提取物,主要成分是倍半萜烯内酯,西方国家较为常用,主要用于治疗皮肤感染、风湿病和偏头痛,但近年来发现小白菊内酯能调控细胞内多种信号途径,如抑制巨噬细胞中脂多糖诱导的Cox,肿瘤坏死因子α和白细胞介素-1的表达,能抑制人单核细胞中iNOS的表达,能抑制Hela细胞中NF-κB的活性,抑制肿瘤细胞的生长,同时能减轻心肌缺血再灌注损伤等,但小白菊内酯在VSMC中的干预研究目前国内外非常罕见,为了确切评价小白菊内酯对血管平滑肌细胞增殖的抑制作用及相关的信号转导机制,我们进行了一些研究。

The degradating and redistributing of ECM were migration of VSMC and vascular remodeling through inhibiting the production of PDGF-BB and the activation of MMPs so to prevent the vascular stenosis.⑤Orthotopic hybridism in situ: The expression of MMP-3 increased after operation, the tendency and intensity were parallel to the expression of NF-κB. Tongxinluo could decrease the expression of MMP-3 and NF-κB. The study showed that the producting and activating of MMP-3 were modulated by NF-κB. The inhibition to the producting and activating of MMp-3 of Tongxinluo was mediated by inhibiting the activating of NF-κB. Conclusion ①The rabbit vascular stenosis model could be established successfully by plain balloon damage, the operation process was easy, economical and practical.

①单纯球囊损伤可成功建立典型家兔血管狭窄模型,操作方法简单,经济实用;②以VSMC增殖、迁移为主的内膜增厚以及以ECM降解、合成与再分布所致的血管重构是导致受损血管狭窄的根本原因;③通心络能明显抑制VSMC的增殖、迁移和ECM降解、合成,阻止血管内膜增生和血管重构,防止受损血管狭窄;该作用可能与其减少和阻止PDGF-BB的产生和活性,以及抑制MMPs的表达和恢复MMPs/TIMPs平衡有关;④通心络能显著抑制球囊损伤后血管内膜增生和血管重构,可能与其保护血管内皮,改善内皮功能,增加血清NO含量有关;⑤通心络抑制内膜增生和血管重构,减轻受损血管狭窄,还可能是通过抑制NF-κB的活化途径而起作用的。

However, inhibiting rates of Ly-CL by sodium benzoate and mannitol were higher than IR of PMN-CL and IR of Ly-CL by supcroxide dis mutase and catalase were lower than IR of PMN-CL.

氧自由基清除剂作用于PMN—CL和LY—CL反应的结果表明,L—组氨酸均明显抑制PMN—CL和LY—CL反应;苯甲酸钠和甘露醇抑制LY—CL反应的抑制率明显高于PMN—CL;而超氧化物歧化酶和过氧化氢酶抑制LY—CL的IR明显低于PMN—CL。

The result indicates thato-PD is converted to one trimer with ca.

羟基自由基抑制剂和氧合血红素物种抑制剂尿酸都不抑制该氧化反应,这些结果表明邻苯二胺的羟基化反应没有包括在其氧化过程中。

The EDTA inhibition dynamics of Ulva pertusa Kjellm alkaline phosphatase and calf intestine alkaline phosphatase were the complexing irreversible inhibition, but these two were different in the inhibition process.

EDTA对孔石莼碱性磷酸酶和小牛肠碱性磷酸酶的抑制动力学均为络合型不可逆抑制,但是二者在抑制过程中具体情况稍有不同。

The inhibition type and inhibition constant were determined based on the responses of apparent kinetic parameters to xanthine concentrations.

据上述参数随抑制剂浓度的变化确定抑制类型和抑制常数(inhibition constant, Ki)。

Results The UV-B treatment caused the declines of chlorophyll content, soluble protein content and water content of leaves, besides, dose-effect was existed. The decline of 30 μW/cm^2 treatment was bigger than that of 15 μW/cm^2 treatment. The influences of UV-B radiation on carotenoid content and anthocyanidin content were similar; the change trends were declined firstly then increased. The UV-B treatment with two doses restrained the electron transport of PSⅡ, particularly; the inhibitory effect was biggest after treated 2h, and then this effect was declined in 4, 6 and 8 h, so the dose-effect was existed. The UV-B radiation with two doses restricted photosynthetic rate and the inhibitory effect increased with the increase of treatment time. The high dose treatment caused huge damage to membrane system, while the result of low dose treatment was not obvious.

结果]UV-B处理导致叶绿素、可溶性蛋白含量以及含水量都降低,且存在剂量效应,30μW/平方公分处理的降幅大于15μW/平方公分;UV-B辐射处理对类胡萝卜素含量的影响与花青素相同,均表现为先下降后上升的趋势,2种剂量间差异不大;2种剂量的UV-B处理均抑制了PSⅡ的电子传递,尤其是处理2 h的抑制作用最大,4、6和8 h的抑制作用有所缓解,且存在剂量效应;2种剂量的UV-B辐射均抑制了叶片的光合速率,随着照射时间的延长抑制效应加大;高剂量UV-B处理对膜系统的损伤较大,低剂量UV-B处理结果不明显。

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According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm~150rpm时取得最大值,此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世,形体几无变化。

When I was in school, the rabbi explained everythingin the Bible two different ways.

当我上学的时候,老师解释《圣经》用两种不同的方法。