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More importantly, in severe combined immunodeficient mice, ZAK, but not the control vector, significantly suppressed tumor growth by H460 cells.

另外我们又使用了siRNA-Elk-1干扰Elk-1表现也可发现在ZAK表现的细胞株其细胞生长速度有回升的情形,而SEAP-AP-1活性同样也被抑制的现象。

At the same time, intracellular DNA was extracted and subjected to Southern blot, hybridized with a ~(32)P-labeled HBV probe and autoradiographed. The intensity of the autoradiographic bands was quantitated by densitometric scans of computer and ED_(50) was calculated.

然后以2.2.15细胞培养为基础,用不同浓度的β-L-D4A进行干预后,经ELISA检测上清液中HBsAg及HBeAg的含量,提取病毒DNA后进行Southern印迹、~(32)P标记HBV探针杂交、放射自显影,经计算机图像处理进行定量分析,求出50%抑制的药物浓度,即EC_(50)。

In the NPC cell lines,loss of BLU expression correlated with hypermethylation of the 20 CpG sites in the 5′ region of BLU(approximately -292bp to -23bp upstream the translation start site)as revealed by bisulphite sequencing. Expression of the gene was restored aftertreatment with 5-aza-2-deoxycytidine in CNE2, suggesting that repression of BLUtranscription might at least be partially mediated by promoter methylation.

结果显示,BLU基因翻译起点ATG上游-292--23bp区间内的20个CpG位点在5例细胞系中均被完全或者部分甲基化,与基因的表达缺失呈负相关关系;去甲基化试剂5-Aza-CdR处理CNE2后基因表达部分恢复,说明甲基化至少是引起BLU基因转录抑制的部分原因。

Poor appetite and bone marrow suppression were observed one week after the craniospinal radiation, and the radiation therapy was ceased. Spinal magnetic resonance imaging showed no spinal matastasis. White blood and platelet counts gradually increased. Subsequently, brain radiation was initiated. The patient currently can walk with good endurance and without device.

中断脑部脊髓放射治疗期间脊髓之核磁共振检查结果无脊髓之转移,白血球及血小板数目已有回升,所以重新开始脑部放射治疗而不再照射脊髓的部分,减少骨髓抑制的并发症;个案食欲不振的现象改善,且口语表达、步行及耐力亦进步中,并於脑部放射治疗结束后出院,改为门诊追踪。

Practice Guidelines for the Prevention, Detection, and Management of Respiratory Depression Associated with Neuraxial Opioid Administration.

与轴索阿片类药物相关的呼吸抑制的预防、监测及处理的实用指南。

Methods Adopting electrophysiological methods,the extracellular discharge signals of neuronic action in NTS were recorded with glass microelectrodes. The effects of acupuncture at "Zusanli"(ST 36),"Neiguan"(PC 6),"Zhongwan"(CV 12),"Qihai"(CV 6) on discharges of NTS neurons and intra-gastric pressure were observed in the rat at normal physiological state,and increase or reduction of gastric motility.

采用神经电生理学方法,用微电极细胞外记录大鼠孤束核单个神经元的活动,观察在正常生理状态及胃运动增强和胃运动抑制的病理状态下,分别针刺&足三里&&内关&&中脘&&气海&对孤束核神经元放电及胃内压的影响。

This research provided some laboratory evidences for elucidating molecular mechanism of the effects of high partial pressure of oxygen on immunity in signal transduction passway and the treatment and prevention of immunosuppression in air diving.

本课题为空气潜水引起免疫抑制的主要原因、防治以及为从信号转导途径揭示高分压氧影响免疫机能的分子机制奠定了一定的实验基础。

Our reults suggested that the ability of rice leaf to resist photoinhibition is related to the level of carotenoids and the ability of carotenoids biosynthesis.

这些表明,水稻叶片抵御光抑制的能力与胡萝卜素水平和胡萝卜素的生物合成能力以及叶片所处的生长时期相关。

Objective To investigate the change of SSeCKS in sciatic nerve after the transection of rat sciatic nerve and its significance.

目的 探讨大鼠坐骨神经切断后,Src抑制的蛋白激酶C的底物在神经中的表达变化及其意义。

The effective concentration of added Ni causing 50% inhibition(EC50)ranged from 11 to 932mg·kg-1 in leached soils which were leached using artificial rain water, and from 7 to 2055mg·kg-1 in unleached soils for the tomato test, respectively, and the ratios of maximum to minimum of EC50 for leached soils and unleached soils were 85 and 294. Soil pH was the main factor controlling the toxicity of Ni in these soils.

在供试淋洗(使用模拟的人工雨水滤洗定量的土壤样品)和非淋洗土壤中,Ni对西红柿生物量50%抑制的毒性阈值(EC50)范围分别从11mg·kg-1到932mg·kg-1和从7mg·kg-1到2055mg·kg-1,其最大值和最小值比例分别达到了85和294倍。

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According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm~150rpm时取得最大值,此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世,形体几无变化。

When I was in school, the rabbi explained everythingin the Bible two different ways.

当我上学的时候,老师解释《圣经》用两种不同的方法。