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The hydroxamic acid compounds can also inhibit histone deacetylase and are suitable for use in selectively inducing terminal differentiation, and arresting cell growth and/or apoptosis of neoplastic cells, thereby inhibiting proliferation of such cells.

所述的异羟肟酸化合物还可以抑制组蛋白脱乙酰基酶并且适合于选择性地诱导终末分化,以及阻止赘生性细胞的细胞生长和/或细胞程序死亡,由此抑制这些细胞的增殖。

That result confirm that the activate spleen-energy method can reduce the concentration of CCK-8S to inhibit the inactivation of IA current to selectively suppress the whole excitability of VMH neurons by the CCK-8S acceptor. This process can suppress excitability of satiety center and promote ingestive behavior.

运脾复方可能是降低了CCK-8S的浓度,通过CCK-B受体的作用减少了CCK-8S对VMH神经元的IA电流的抑制作用,进而选择性地抑制了VMH神经元的整体兴奋性使饱中枢兴奋性降低,从而达到促进摄食的目的。

A coronary microthromhoembolism model was successfully established by injecting sodium laurate into the coronary arteries. Coronary micro-thrombogenesis may promote the apoptosis of cardiomyocytes, and is one of the reason for heart function decrease. Telmisartan can efficiently suppress ventricles reconstruction, improve heart function, and inhibit the apoptosis of myocardial cells after microthrombogenesis in coronary artery.

冠状动脉内注射月桂酸钠能够成功建立冠状动脉微血栓的模型;冠脉内微血栓增加心肌细胞的凋亡,是导致心功能下降的原因之一;替米沙坦能有效地抑制心脏重塑,改善心功能,并能抑制冠脉微血栓后心肌细胞的凋亡。

That have been scientifically proven; Second, is the inhibition of tumor growth, which is a lot of traditional Chinese medicine has a role, such as goldenrod, Mahonia leaves, nine tea, into the earth Taurus, Aug bar, octagonal lotus, the brother Wang and so can inhibit cancer cell growth; again, is to enhance macrophage function, and many herbs are to promote the role of phagocyte cells, such as cinnabar lotus, grass, etc. Ganoderma lucidum.

这都得到了科学证明;其次,就是抑制肿瘤生长,这是很多中药都有的作用,如一枝黄花、十大功劳叶、九节茶、入地金牛、八月扎、八角莲、了哥王等都能抑制癌细胞生长;再次,就是增强吞噬细胞功能,很多中草药都有促进吞噬细胞吞噬癌细胞的作用,比如朱砂莲,灵芝草等等。

The results showed that most of the microbes could be inactivated for the ultra high pressure treatment, the accumulation of total volatile basic nitrogen was restrained, and the change of pH value was delayed. The shelf life of white shrimp was prolonged with the enhancement of high pressure. High pressure treatment could make fresh shrimp with boiled flavor in some degree. Trements of 400 Mpa and 600 MPa aggravated blackening. However, melanotic reaction was not observed during the whole storage of shrimp treated by 700 MPa. High pressure could change the metabolizing of ATP and its metabolites, but did not impact the metabolic pathway of AMP decomposition.

结果表明:超高压处理可以有效地杀灭南美白对虾中绝大多数微生物,抑制贮藏过程中挥发性盐基氮的积累,延缓pH值的变化,从而延长南美白对虾的货架期,且处理压力越高延长效果越显著;超高压处理会给鲜虾带来不同程度上的煮熟虾的风味;400 MPa和600 MPa处理使虾在冷藏过程的黑变提前,而700 MPa处理可以完全抑制南美白对虾黑变现象的发生;超高压能够改变腺苷三磷酸及其代谢产物的代谢情况,但不影响腺苷酸的代谢途径。

Results Both of them can effectively inhibit the aggregation of neutrophilic granulocytes and had some inhibiting effect on free-radical of oxygen,especially cimetidini.

结果:两者均能有效地抑制嗜中性粒细胞在肺内的聚集,对氧自由基的产生有一定抑制作用,西米替丁的作用更为明显。

We also demonstrate that BH3-only protein Noxa is upregulated during Camptothecin-induced apoptosis, which is independent of p53. In addition, we show that PI3k/Akt signaling pathway is responsible for Noxa\'s induction.

更重要的是,用RNAi的方法将Noxa的蛋白水平抑制之后可以显著地抑制CPT诱导的细胞凋亡,暗示Noxa在CPT诱导细胞凋亡的过程中起着非常重要的作用。

Results:Peroral A_3 (0.001 g/kg、0.005 g/kg and 0.01 g/kg) could dose-dependently inhibit dimethylbenzene-induced mice ear edema.

结果:A_3 0.001 g/kg、0.005 g/kg和0.01 g/kg可剂量依赖性地抑制小鼠耳廓肿胀,抑制率分别为10.6%、21.1%和53%( n=10)。

Currently, the role and mechanism of action for most of these inhibitiors are being studied in detail. This article describes the structure of PIs genes, their regulation and expression, and discusses the strategy to develop transgenic plants against phytophagous insects.

目前,大多数抑制剂的作用和机理正在详尽地研究中,该文综述了植物蛋白酶抑制剂的基因结构、调控与表达并讨论了培育转基因作物控制害虫的策略。

Currently,the role and mechanism of action for most of these inhibitors are being studied in detail.This article describes the structure of PIs genes,their regulation and expression,and discusses the strategy to develop transgenic plants against phytophagous insects.

目前,大多数抑制剂的作用和机理正在详尽地研究中,该文综述了植物蛋白酶抑制剂的基因结构、调控与表达并讨论了培育转基因作物控制害虫的策略。

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