抑制因素

Objective To explore livin, MTA1 and the caspase3 protein expression, their correlation and clinical pathology in colon cancer Methods The expressions of livin, MTA1 and caspase3 protein in 88 cases of colon cancer were detected by immunohistochemistry stainingResults Livin, caspase3 protein and MTA1 positive expression rates in colon cancer tissues were more than those in tissues beside the cancer Furthermore there were obvious relevance between livin protein, MTA1 positive expression rate and degree of histodifferentiation and lymph node metabasis and between caspase3 protein positive expression rate and degree of histodifferentiation of colon cancer Caspase3 protein expression had prominent inverse correlation with the livin expressionConclusions ①Over expression of livin having inhibtion on colon cancer is one of important factors of colon carcinogenesis ②Caspase3 protein expression in colon cancer tissues is inhibited to less and has prominent inverse correlation with livin expression Accordingly, suppressing caspase3 protein activity is one of channels, by which livin promotes colon carcinogenesis ③MTA1 plays the important role in histodifferentiation degree and lymph node metastasis of colon cancer

采用免疫组织化学染色方法检测88例结肠癌组织中Livin，Caspase3 及MTA1的表达情况。结果（1）结肠癌组织中Livin的阳性表达率显著高于癌旁组织，且Livin的表达与结肠癌的组织分化程度及淋巴结转移程度显著相关。（2）结肠癌组织中Caspase3蛋白的阳性表达率显著高于癌旁组织，且Caspase3蛋白的表达与结肠癌的组织分化程度显著相关。（3）结肠癌组织中MTA1的阳性表达率显著高于癌旁组织，且MTA1的表达与结肠癌的组织分化程度及淋巴结转移程度显著相关。（4）Caspase3蛋白的表达又与Livin的表达呈显著负相关。结论（1）Livin在结肠癌组织中过表达，它可能是促进结肠癌发生的重要因素之一。（2）Caspase3蛋白在结肠癌组织中表达被抑制而降低，且与Livin的表达呈负相关。因此，抑制Caspase3蛋白的活性是Livin促进结肠癌发生的途径之一。（3）MTA1对结肠癌的组织分化及淋巴转移发挥重要作用。

Preliminary study revealed the devascular effect of PYM correlated with the inhibitory of vascular endothelial cells.

一、PYM抑制人脐静脉内皮细胞生长的体外研究目的通过体外实验观察PYM对人脐静脉内皮细胞株一一一石CV304细胞生长、增殖和凋亡的影响，以证实PYM对血管内皮细胞的抑制作用及了解相关的影响因素。

SLE is involved in immediate allergic II~IV types reactions. The overexpression of immediate allergic reactions can be the potential factor to induce cell apoptosis. In the past researches, cystamine which is the inhibitor of TG2 and caspase can slow down the expression of SLE through suppressing cell apoptosis and also can prolong the ratio of surviving in NZB/W F1 mice model in serological and protein test.

其广泛的牵涉了II~IV型的过敏反应，过敏反应的过分激活为自体抗体大量产生引发细胞apoptosis的潜在因素，在本实验室过去曾发现在NZB/W F1 mice作为实验动物模式之下，以cystamine此TG2及caspase的抑制剂具有在血清学及蛋白检测中均可透过抑制细胞的凋亡，进而减缓SLE达到保护的作用，改善狼疮病症，且延长其存活率。

But in practical operating, overvoltage caused by reignition of the vacuum switching device frequently appears, and it result in damage of the capacitor bank or the switchgear itself. Ensuring the switchgear against reignition and installing a protective device are two main approaches to avoid the phenomenon. In this paper, a study on overvoltage caused by reignition due to capacitor bank switching with the vacuum switching device and its preventive measures are carried out. The main work which has been done and researches are as follows: 1. The producing mechanism of overvoltage and its influence factor are analyzed. It is pointed out that single-phase reignition is the main reason for damage of the switchgear and two-phase reignition is the main reason for damage of the capacitor bank,so overvoltage of single-phase reignition and two-phase reignition are the emphases of prevention. 2. Analysis of the special working condition of the operating switch for capacitor bank is carried out. It indicates that the vacuum switching device is difficult to realize no-reignition under this operation condition, so it is more practical to adopt protection devices. 3. Analyses of protection effect of RC and MOA and their shortages are carried out. It shows that the two methods can only restrain effectively overvoltage caused by single-phase reignition, and they cannot protect the capacitor bank when reignition of two-phase occurs. 4. The operation principle of G-R damping device is analyzed and discussed emphatically.

本文针对真空开关投切电容器组时因重燃而产生的过电压及其防治措施进行了研究，所开展的主要工作和研究结果如下： 1、对过电压的产生机理及其影响因素进行了分析，指出单相重燃是导致开关设备损坏的主要原因，而两相重燃则是导致电容器组损坏的主要原因，因此单相重燃和两相重燃过电压是防护的重点； 2、对电容器组操作开关的特殊运行条件进行了分析，指出在这种运行条件真空开关难于实现不重燃，因此采用保护装置更具有现实意义； 3、对RC与MOA的保护效果和存在的不足进行了分析，指出这两种方法均只能有效抑制单相重燃过电压，而不能在发生两相重燃时保护电容器组； 4、重点对G-R阻尼装置的工作原理进行了分析和讨论，指出该装置接入后线路中将会出现两种频率的高频振荡，而电容器组上的过电压是由这两种振荡共同决定的； 5、根据对上述两种振荡的分析指出存在一个最佳电阻值使得过电压最低，并提出了电容器组电压和最佳电阻值的近似求解方法； 6、使用电气暂态分析软件MATLAB对G-R装置的保护效果进行了仿真计算，证实该装置确实可以有效抑制重燃时的电容器组过电压； 7、根据仿真与近似计算结果的偏差提出了近似计算的修正方法，经过修正后的过电压计算结果与仿真结果吻合较好； 8、对G-R装置中放电装置G与阻尼电阻R的要求进行了分析，指出采用编织电阻和真空间隙可能是最佳选择。

The change of GR plays an impor trant role in low suppressive effect of PLA2.There was a negative correlation between PLA2 and GR from early stage to 72 hours after injury. The suppressive effect of glucocorticoid to PLA2 is relative to GR.

2GR减少是PLA2抑制作用低下的重要因素，早期至72hPLA2与GR改变呈负相关，糖皮质激素对PLA2 的抑制作用与GR水平密切相关。

During the stationary phase of fermentation, cell productivity was slightly reduced. MgSO_4 and tryptone have the positive effect on the product synthesis and cell growth respectively. Based on these conclusions, MgSO_4 and tryptone were added to the feed medium to enhance the production of polysialic acid. Variable feed rate policies were applied to the fed-batch fermentation process and the final biomass and polysialic acid production were both increased by 40 percent.

通过摇瓶实验研究了大肠杆菌发酵过程中菌体生长和产物合成的影响因素，结果表明：产物合成与菌体生长是相耦联的过程，菌体生长受到菌体代谢产物的抑制作用，聚唾液酸的合成不受代谢产物的抑制作用；发酵进入稳定期后菌体的生长和生产能力有所降低；硫酸镁和胰蛋白胨分别对产物合成和菌体生长有一定的促进作用。

The key problem for limb , skin or other composite tissues transplantation is to control posttransplantation rejection , which encumbers long term functional survival of transplanted organ and tissues .

作为皮肤复合组织移植的受者，术后出现排斥反应的几率很高，排斥反应发生的程度和频率将直接影响移植组织能否长期存活及功能能否及时恢复，而免疫抑制剂的个体化用药是否合理又直接影响术后免疫排斥反应发生的频率和程度，因此为受者&量体裁衣&制定免疫抑制剂术后个体化给药方案，是保证移植组织或器官有功能性的长期存活的关键因素之一。

JJYNJ granules could significantly improve the symptoms of experimental hyperthyroidism graves. Its mechanisms may be different from that of thiamazole, which is related to inhibiting the synthesis of thyroxin in thyroid.

加减玉女煎具有抑制实验性甲状腺功能亢进症的作用，其作用机制可能主要不是抑制甲状腺素合成而与拮抗甲状腺激素的作用或其他因素有关。

JJYNJ granules could significantly improve the symptoms of experimental hyperthyroidism graves. Its mechanisms may be different from that of thiamazole, which is related to inhibiting the synthesis of thyroxin in thyroid.

加减玉女煎具有抑制实验性甲状腺功能亢进症的作用，其作用机制可能主要不是抑制甲状腺素合成而另与拮抗甲状腺激素的作用或其他因素有关。

The effect factors analysis based on FEM shows that: Raising the strength of concrete and the thickness of cover concrete would delay the cracking of concrete; Stress superposition would appear due to the influence of adjacent rebar, and increasing the rebar space would postpone the time of cover cracking; Stirrup could suppress the cracking of cover concrete, however, the effect is limited and the corrosion-degree-ratio and corrosion expansive force would not increase until the cover concrete cracking happens completely.

结合有限元分析结果，对影响锈胀开裂的各因素进行了分析，结果表明：提高混凝土强度、增加保护层厚度有助于延缓保护层的开裂；相邻钢筋的存在会使钢筋之间的混凝土出现应力叠加现象，箍筋对混凝土保护层内由锈胀产生的应力具有抑制作用，但是在保护层完全开裂之前，箍筋的抑制作用有限。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。