抑制因素

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗(来源：A44B8787C论文网www.abclunwen.com)功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

They will also highlight whether the AML will increase the cost of doing business in China and therefore create a disincentive for foreign investment.

这些实施细则的出台，同时也将突出这样的问题：反垄断法是否会提高在中国经营的成本，并因此是否将成为外商在华投资的抑制因素。

This would create an economic disincentive to kill—shooting a rival would badly disrupt gang business.

这就产生了对杀人的抑制因素-击杀竞争对手会严重的扰乱帮派生意。

Under appropriate conditions embryonic stem cells have been shown to differentiate in vitro to multiple cell types of endoderm, mesoderm and ectoderm.

一旦撤除分化抑制因素，或添加适当的诱导剂，ES细胞可分化为内胚层、中胚层和外胚层的多种类型的特化细胞。

In this paper, we discuss and analyze some potential inhibition factors concerning PCR.

本文就核酸扩增过程中可能的抑制因素进行分析和讨论。

Inhibitors of the enzyme monoamine oxidase were also discovered to have antidepressant properties.

单胺氧化酶的抑制因素有看抑郁的性质也被发现。

These pads are soft, dampening elements that reduce sound and vibration as the energy chain is moved.

这些垫子是软，抑制因素，减少声音与振动的能源链是感动。

"Being overweight should not be a disqualifying and discriminating factor against these patients," lead author Dorry L.

December 19， 2007 —根据一项发表於12月19日美国肾脏医学会期刊的研究结果，在治疗肥胖病患方面，较差的预后与金融上的抑制因素，可能造成他们受到忽略，有时许多情况是发生在肾脏移植上；相较於正常体重病患，肥胖病患接受肾脏移植的机会可能较低。

However, development of cement industry will also face disadvantageous factors: 1 along with the coming of high cost epoch, continued rising in costs of coal, power, mineral resources, environment, human resource and capitals and the increase in social responsibilities that enterprises should take on will bring restricting factors to the investment and development of cement industry; 2 on the basis of the gradual increase of industrial concentration, market competition will change from the current competition between large enterprises and small enterprises and between new dry process and backward shaft kiln technology to the competition among large enterprises and among new dry processes, so the extent of market competition may further extend; 3 along with RMB increasing in value, demand decreasing in north America, new production lines in Middle east being put into operation and the persistent high price of international shipping, national cement export will face huge menace; backward flow of export products will certainly aggravate market competition in some areas.

但水泥行业的发展也将面临不利因素。一是随着高成本时代的到来，煤炭、电力、矿产资源、环境、人力、资金等成本的不断提高及企业所承担的社会责任的增加，将对水泥工业的投资和发展平添抑制因素；二是在产业集中度逐步提高的基础上，市场的竞争将由目前大企业与小企业、新型干法与落后立窑工艺之间的竞争转为大企业与大企业、新型干法与新型干法之间的竞争，市场竞争的程度有进一步加大的可能；三是随着人民币的升值、北美市场需求的下降、中东新生产线的投产及国际航运价格的居高不下，我国水泥出口将面临巨大的威胁，出口产品的回流，势必将加剧局部地区的市场竞争。

As she looked at Warrington's manly face, and dark, melancholy eyes, she had settled in her mind that he must have been the victim of an unhappy attachment.

每逢看到沃林顿那刚毅的脸，那乌黑、忧郁的眼睛，她便会相信，他一定作过不幸的爱情的受害者。

Maybe they'll disappear into a pothole.

也许他们将在壶穴里消失