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Histamine deficiency markedly potentiated the acquisition of learning in cued and contextual fear conditioning in the HDCKO mice,but had no effect on cued and contextual fear extinction.However,histamine deficiency potentiated the inhibitory role of morphine withdrawal in cued fear extinction.Consistent with the behavioral results,morphine withdrawal decreased ERK phosphorylation in the amygdala and mPFC but not in the hippocampus of WT and HDCKO mice,and ERK might not be phosphorylad in the amygdale and mPFC of HDCKO mice after the 4th training of cued fear extinction.

但HDCKO小鼠增强了吗啡戒断对线索恐惧记忆消除的抑制作用,与行为学实验结果相一致是,,吗啡戒断能明显降低WT和HDCKO小鼠在线索恐惧记忆消除第4次训练后杏仁核和mPFC脑区的ERK磷酸化水平,但对海马脑区的ERK磷酸化没有作用;HDCKO小鼠在线索恐惧记忆消除训练的第4次训练后杏仁核、mPFC脑区的ERK蛋白没有明显磷酸化激活。

To identify the possible cytokines which may be invovled in this process,we used neutralizing antibodies of DKK-1 and TGF-βto treat AFMSC when cocultured with K562 cells and found that it was DKK-1 not TGF-βthat participated the process.

由于成熟的基质细胞不存在抑制肿瘤增殖的作用,我们推测可能是AFMSC的内在特性决定了这种作用的发挥。

This is a review of recent studies on the relationship between fire and invasive plant species.

在植物外来种与火生态因子的作用研究中发现,火与外来种的关系随物种生物学特性、火作用的时间、频度、强度不同而不同,火有时会有效地抑制外来种的生长和入侵,有时会促进一些外来种的生长和入侵。

The effects of spent culture supernatant on the adhesive ability of heat-killed Bifidobacterium were also studied. Results Bifidobacterium had good adhesive abilities to HT-29 cells.

双歧杆菌粘附于肠黏膜上皮细胞是其发挥作用的首要条件,粘附作用发生后形成的生物屏障阻止了致病菌的入侵和定植,使肠道菌群得到改善,从而抑制了多种疾病的发生。

In vivo, composition E markedly protected mice from lethal challenge by heat-killed E. coli and heat-killed S. aureus. Conclusions:(1) Targeting on PGN, CpG DNA and lipid A, we successfully established the platform to screen anti-inflammatory traditional Chinese medicine using biosensor technology which is highly effective, objective and feasible.

该组分经MTT法测定对小鼠RAW264.7细胞活力无影响(≤400μg/ml),经CCK-8法测定也对小鼠RAW264.7细胞活力无影响(≤800μg/ml);对PGN、CpG DNA及LPS刺激小鼠RAW264.7细胞分泌TNF-α有显著的抑制作用,并呈现良好的剂量-效应关系;对致死剂量的热灭活大肠杆菌和热灭活金黄色葡萄球菌攻击小鼠有显著的保护作用。

Methods Fe2+VitCinduced lipid peroxidation damage models were established by rat liver microsomes extraction. The expressions of malondialdehyde and superoxide dismutase were tested.

通过大鼠肝微粒体的提取,制备Fe2+VitC系统诱导的脂质过氧化损伤模型,检测车前子多糖对丙二醛的抑制作用以及对超氧化物歧化酶活性的影响,观察车前子多糖的抗脂质过氧化作用。

Result: The series of Muskone can improve myocardial ischemia and infarction in experimental canines, and relieve significantly the degree of myocardial ischemia determined by epicardial electrogram mapping,decrease the range of myocardial ischemia determined by epicardial electrogram mapping and decrease infarction zone determined by N-BT staining method. And it has a significant inhibition on activity of ET induced by myocardial ischemia and infarction, and increases 6-Keto-PGF1αand 6-Keto-PGF1α/TXB2 induced by myocardial ischemia.

结果:冠心苏合丸系列组方具有明显改善犬急性心肌缺血和心肌梗死的作用,明显减轻由心外膜电图标测的心肌缺血程度及范围;减小经N-BT染色所显示的梗死区;对心肌缺血及心肌梗死引起ET的活性有明显抑制作用,同时升高血浆6-Keto-PGF1α和6-Keto-PGF1α/TXB2的比值。

The simulated test of compound contamination with Cd and Pb showed that, at a certain concentration, Cd inhibited potherb mustards to absorb Pb, and Pb promoted them to absorb Cd.

Cd、Pb复合污染实验显示在一定的重金属浓度范围内,Cd对Pb的吸收有一定的抑制作用,Pb对镉Cd的吸收有一定的促进作用。

He results show that the virus regained infectivity, and the tannins did not direct viricidal effect. Tannins extracted from Polygonum perfoliatum or Archontophoenix alexandrae seeds showed strongly anti-TMV activities separately. TMV virions seems to be aggregated when TMV incubated with the tannins by electron microscope. It seems that TMV coat protein bind to the tannins based on PAGE. Tannins did not reduce infectivity when applied either before or after TMV inoculation. It is proposed that tannins extracted from the 11 species inhibited TMV by binding with TMV coat protein to interfere with recognition site essential for viral coat protein. Tannins extracted from Euphorbia hirta, P. perfoliatum, P. cuspidatum reduce infectivity when applied immediately in N.

MV分别与这11种植物单宁混合后,通过透析除去单宁后,可恢复大部分侵染力,表明单宁对病毒粒体并无直接毒害作用;TMV与杠板归和假槟榔种子中提取的单宁分别混合后,电镜下观察粒体呈现明显的聚集现象;TMV外壳蛋白分别与这两种植物单宁混合后,聚丙烯酰胺凝胶电泳中CP泳带滞后;单宁在病毒接种前施用未降低TMV对叶片的侵染能力;这些结果表明植物单宁对TMV抑制作用可能是单宁与TMV-CP结合影响病毒对叶片侵染位点的识别而降低TMV侵染性,而这种结合是可逆的。

It is found to relate to atherosclerosis, increasing tension of coronary artery, coronary vasospasm, coronary thromboses and vascular restenosis after percutaneous transluminal coronary angioplasty that endothelium reduce generation and re lesae of EDRF/NO.

随着内皮分泌功能的发现,人们逐渐认识到内皮不仅仅是具有单纯弥散屏障作用的细胞成份,它还有:1、调节血管舒缩;2、防止血栓形成;3、大范围的激素调节;4、促使或抑制内皮本身和血管平滑肌细胞的增生;5、调节儿茶酚胺、血小板产物的代谢和失活等作用。

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According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm~150rpm时取得最大值,此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世,形体几无变化。

When I was in school, the rabbi explained everythingin the Bible two different ways.

当我上学的时候,老师解释《圣经》用两种不同的方法。