抑制作用的
- 与 抑制作用的 相关的网络例句 [注:此内容来源于网络,仅供参考]
-
The results show that: This tablet can decrease the rat"s footpad swell induced by Freud"s, inhibit the permeability of the blood capillary in inflammatory joint and decrease the 11-2 level in serum while increasing the rat"s body weight,(2) It can lower the rat"s temperature and the permeability of the blood capillary in inflammatory joint induced by collagen and inhibit the delayed type hypersensitivity,It can lower the stickiness of full blood and the accumulation of erythrocyte obviously inblood stasis model rats,lt can inhibit the formation of hemolysin and decrease the index of carbon granule clearance in mice, It can lower the permeability of celiac blood capillary and inhibit the granulomatous hyperplasia by sc cotton ,It can inhibit the pain induced by acetic acid and raise the pain threshold value of heat stimulation.
结果表明:关络通片能明显降低佐剂性关节炎大鼠左右足趾肿胀度,降低大鼠炎症关节的通透性,抑制其IL-2含量,对大鼠体重增长缓慢有一定的改善作用;能改善Ⅱ型胶原诱导性关节炎大鼠的表征指标及炎症关节的通透性,对其迟发型超敏反应有一定的抑制作用;对血瘀模型大鼠,能显著性降低其全血粘度、血浆粘度、红细胞压积;能抑制小鼠的溶血素抗体生成,抑制小鼠网状内皮系统的吞噬能力,具有一定的抑制机体免疫功能的作用,能抑制小鼠腹腔毛细血管通透性增高,抑制大鼠棉球肉芽组织增生,具有一定的抗炎作用;能抑制小鼠醋酸扭体反应、提高小鼠热板痛阈值,具有一定的镇痛作用。
-
objective to observe the antitumor activities of different solution extracts of plumbago zeylanica l.in vitro.method mtt method was used to detect the inhibitory effects on four kinds of cancer cells.results chloroform extracts had significant inhibitory effects on the breast cancer cell(bre-04),the nerve cancer cell(n-04) and the lung cancer cell(lu-04),ic50 were 0.2699mg/ml and 0.2634mg/ml,0.4961mg/ml respectively.ic50 of chloroform extract on the hepg2 was 0.9379mg/ml.ic50 of petroleum ether extracts on bre-04,n-04,lu-04 and hepg2 was 0.5902mg/ml,0.5725mg/ml,0.7938mg/ml,0.6374mg/ml;ethyl acetate extracts had fairly inhibitory effects on the lu-04,ic50 was 0.7343mg/ml;n-butanol extracts and water-solubility extracts had notsignificant inhibitory effects on the four kinds of cancer cells.conclusion the antineoplastic effective parts of plumbago zeylanica l.were chloroform and petroleum ether extracts.
目的 探讨白花丹体外抗肿瘤作用的活性部位。方法 mtt染色法对白花丹五种溶剂提取物体外抗肿瘤活性进行了初步的研究。结果氯仿提取物对乳腺癌细胞(bre-04)、神经癌细胞(n-04)、肺癌细胞(lu-04)有较好的抑制生长作用,ic50分别为0.269 9 mg/ml、0.263 4 mg/ml、0.496 1 mg/ml,对肝癌细胞hepg2抑制作用差, ic50为0.937 9 mg/ml;白花丹石油醚提取部位对乳腺癌细胞(bre-04)、神经癌细胞(n-04)、肺癌细胞(lu-04)、肝癌细胞hepg2的ic50分别为0.590 2 mg/ml、0.572 5 mg/ml、0.793 8 mg/ml、0.637 4 mg/ml;乙酸乙酯提取物对肺癌细胞(lu-04)有一定的抑制作用,ic50为0.734 3 mg/ml;水溶性提取物以及正丁醇提取物无明显抑制肿瘤作用。结论白花丹氯仿提取部位、石油醚提取部位体外抗肿瘤作用较好,值得对其提取部位进一步分离纯化并研究其抗肿瘤作用机制。
-
AIM: To isolate bioactive secondary metabolites from the fruits of Schisandra rebriflora Rehd. et. Wils and study their effects on HIV-1 infectivity. METHODS: Inhibition of syncytia formation, HIV-1 reverse transcriptase and protease, protection of HIV-1 infected cells, level of HIV-1 p24 antigen,blockage of fusion were detected. RESULTS: A lignan compound, named rubrifloralignan A, was first isolated as a natural product with modest inhibition effects on syncytium formation and HIV- 1 replication and could protect HIV-1 infected cells with weak inhibition effects on fusion and RT, but it showed no effects on the replication of HIV-1 chronic H9 and PR. CONCLUSION: Rubrifloralignan A is an efficient anti-HIV-1 product with effect on early stage of HIV-1 replication.
目的:从红花五味子果实中寻找活性代谢产物,研究其抗HIV—1活性和作用机制方法:通过合胞体抑制、HIV-1感染细胞保护、HIV—1p24抗原测定、融合阻断、逆转录酶和蛋白酶活性分析等实验,检测分离化合物的抗HIV—1活性并探讨其作用机制一结果:红花五味子甲素能够抑制病毒诱导的合胞体形成,保护病毒感染细胞,抑制病毒在细胞内的复制对HIV-1感染细胞与正常CD4^+细胞间的融合,逆转录酶活性有一定的抑制作用但是红花五味子甲素不抑制病毒在慢性感染细胞中的复制,也不抑制蛋白酶的活性、结论:首次从天然产物中分离得到红花五味子甲素,它对HIV—1病毒复制早期具有抑制作用
-
DCs acquired by our reformed methods express both CD83 and CD 14 molecules highly, and have a higher density than other domestic reports. The higher TNF in DCs culture medium of HC patient suggests DCs in patient still have antigen presenting ability and by optimization the culture medium would improve its presenting ability and have a potential value in design and application individual vaccine. Although antigens pulsed DCs have a decrescent antigen presenting ability but BCG HSP70 could induce its mature and improve its presenting ability. Suggests BCG HSP70 would be a useful mature inducer. Lymphocytes primed by DCs based HC vaccine have the specific cytotoxicity against HCC lines. The CTL after freezing and anabiotic could prophylaxis and therapy HC xenograft on nude mouse. The results also suggests that CD4〓 lymphocytes play a important role in HC with a good differentiation and would be useful in treatment this kind of HC. After being activated by Peptide LLNQHACAV of hAFP and apoptotic HCCs pulsed DCs respectively, the culture medium of activated lymphocytes both contains a high level Th1 cytokines IL-12 and TNF. Primed lymphocytes appeared a characteristic of NK cells. DCs not only inhibited the growth of human HCC and other cancer cells in vitro but also prevented the growth of HC xenograft on nude mouse in vivo. There are at least three kinds of mechanism playing important role in DC based vaccine ,there are inhibition of DCs, HC specific CTL and cytokines pathway.
诱导出的DC共同表达CD83和CD14分子,CD83分子表达明显高于国内报道;肝癌患者DC培养上清中TNF水平高于健康人,提示肝癌患者DC仍具一定的抗原呈递能力,适当调控可使其行使APC功能,以期在肝癌个体化疫苗中发挥作用;DC负载肝癌可溶性抗原后,抗原呈递能力降低,BCG HSP70可促进DC成熟,增加其抗原呈递能力,预示BCG HSP70有可能成为促进DC活化和成熟的另一重要分子;肝癌DC疫苗在体外诱导肝癌特异性淋巴细胞,活化的淋巴细胞在体外对肝癌细胞的杀伤以特异性CTL为主,同时分泌较高水平Th1型细胞因子IL-12和TNF,并抑制4种肝癌细胞生长;冷冻复苏后的肝癌特异性淋巴细胞可以预防和抑制人肝癌裸鼠皮下移植瘤,提示DC负载肝癌可溶性抗原后诱发的MHC-Ⅱ类限制性CD4〓T细胞有可能在分化程度高的肝癌治疗中发挥作用;用DC和HLA-A2〓DC分别负载凋亡肝癌细胞和hAFP218-226位LLNQHACAV HLA-A2限制性九肽,在体外诱导肝癌特异性淋巴细胞,活化后的CTL细胞分泌较高水平的Th1型细胞因子IL-12和TNF,并具较强杀伤活性,此CTL同时具备NK细胞特征;DC对肿瘤细胞的抑制作用可能是通过吞噬实现的,Fas-L在DC抑制中也起一定作用;DC对人肝癌裸鼠皮下移植瘤的抑制率为97%;在肝癌DC疫苗的作用中,至少联合3种以上机制,即通过DC的直接作用、肝癌特异性CTL和细胞因子途径直接或间接地杀伤和抑制肝癌细胞。
-
Wenxin capsule can promote endolethial cells releasing CO and synthesing 〓, enhance activity of HO, induce angiectasis through activating guanylic cyclase and adenglate cyclate of intracellar of vessel smooth muscle cell to enhance content of intracellar cGMP and AMP. 3. Wenxin capsule can inhibit releasing of platelet activiting factor 〓 which inhibit platelet aggregation and have antithrombosis function. 4. Wenxin capsule can promote activity of t-PA, reduce activity of PAI-1, strengthen fibrinolytic function, therefore inhibit fibrin disposition. 5. Wenxin capsule can inhibit synthesis of smooth muscle cellular DNA. Its function don't kill it directly but prevent transformation from period Go to peried S. 6. Wenxin capsule is an effective prescription of anti-coronary atherosclerosis atherosis. The results of image pattern analysis tastifies that area of lipid plaque in treating group reduce 54% and 58% in contrast with that in control group. The results of light, electro- microscopy show that structure of endolethial cell and smooth muscle cell in treating group is more integral than that in control group.
其作用机制之一是由于该药具有良好的调脂降脂作用,其不仅能明显降低血清LDL-c及升高HDL-c含量,且能有效阻止TC沉积于血管壁,从而保护内皮细胞结构完整;此外,温心胶囊尚具有明显的抗氧化作用,该药不仅能明显降低血浆LPO含量,且能提高SOD活性,同时其对血红素在细胞内代谢的调节作用也参与了抗氧化过程。2 温心胶囊能明显促进内皮细胞释放CO及合成〓,提高HO活性,通过激活血管平滑肌细胞内鸟苷酸环化酶及腺苷酸环化酶引起细胞内cGMP、AMP浓度增加而引起血管舒张。3 温心胶囊能明显抑制血小板激活因子〓的释放,从而抑制血小板聚集,抗血栓形成。4 温心胶囊能明显提高t-PA活性,降低PAI-1活性,增强纤溶功能,从而抑制纤维蛋白沉积。5 温心胶囊能明显抑制平滑肌细胞DNA合成,其抑制作用不是直接杀伤抑制,而是阻止细胞由Go期向S期转化。6 温心胶囊是抗冠状动脉粥样硬化的有效制剂,图象分析结果证实,该药治疗组脂斑面积比对照组缩小了54%和58%,光电镜结果显示内皮细胞及平滑肌细胞结构较为完整。
-
The fungicidal activity of methanol extract was higher than that of ethylacetate extract. The bioassay showed that the methanol extracts of strain As fermentation products had certain degree fungicidical activity against Botrytis cinerea, Alternaria longipes, Glomerella cingulata, Curvulavia lunata, Gibberella zeae, Valsa malt under the concentration of 4000μg/mL, the inhibiting ratio against pathogen growth was ranging from 62.9%~85.1%; The results of the inhibition of spore germination indicated that the fermentation products exhibited obvious inhibition rate against Alternaria longipes, the EC50 values was 62.5328μg/mL; The bioassay showed that the methanol extracts of strain As fermentation products had certain degree fungicidical activity against Bacillus cereus , Bacillus subtilis.
其中甲醇提取物的抑菌活性较乙酸乙酯好,在4000μg/mL浓度下对番茄灰霉病菌、烟草赤星病菌、苹果炭疽病菌、玉米弯孢叫斑病菌、小麦赤霉病菌、苹果腐烂病菌6种植物病原真菌均有抑制作用,抑制率在62.9%~85.1%;抑制孢子萌发试验表明:菌丝体甲醇提取物对烟草赤星病菌的毒力较好,其EC50仅为62.5328μg/mL;抑制细菌活性表明菌丝体甲醇提取物对蜡状芽孢杆菌和枯草芽孢杆菌有一定的抑制作用,而对大肠杆菌无明显的抑制作用。
-
The inhibition substances in Sorbus pohuashanensisHedl fruit not only restrained the seeds of wheat, cabbage from germinating but also restrained height and root growth. After the seeds of wheat, chinese cabbage had been soaked in the water extraction of pulp, seed and decoated seed for 8h, the seed germination rates were 92% and 84%, 89% and 65%, 94% and 78%, lower than the control, especially the water extract of decoated seed; and the root length and seedlings height were lower than the control, especially the water extract of pulp, and decreased in sequence of soaking time from short to long. So the simplest and effective method to eliminate pulp soluble inhibiting substances is to wash fruits by flowing tap water soon after collection.
在几种浸泡时间中,浸泡8小时的去皮种子浸泡液对白菜、小麦种子发芽率的抑制作用最为明显,其发芽率分别为65%、89%,但随着浸泡时间的延长而降低;浸泡8h的果肉浸泡液对白菜和小麦幼苗高生长和根伸长的抑制作用最为明显,种子和去皮种子浸泡液(8h)的抑制作用对小麦和白菜的抑制作用次之,随着浸泡时间的延长,果肉浸泡液的抑制作用逐渐减弱,因而采收下来的果实及时净种是清除果肉水溶性抑制物质简单有效的方法。
-
On the inhibition to mycelial growth, the 95% ethanol extract had significantly inhibition to P. ultimum, F. oxysporum f. sp cucumber, R. solani and B. cinerea, and at the top treatment concentration of 0.002 g/mL, the inhibition rate reached to 60.32% 58.50%, 55.89% and 55.17%, respectively; But the 95% ethanol extract almost had no inhibition to S. rolfsii, its rate was just 17.19% at 0.002 g/mL.③On the inhibition to sprouting, the 95% ethanol extract had significantly inhibition to B. cinerea, R. solani, F. oxysporum f. sp cucumber and P. ultimum, and at the top treatment concentration of 0.002 g/mL, the inhibition rate reached to 95.24%, 90.48%, 89.47% and 85.71%, respectively; and the rate would exceed 40% to four fungi mentioned above when their concentration was not lower to 0.005g/mL. The 95% ethanol extracthad infirm inhibition to S. rolfsii, its rate was just 43.48% at 0.002 g/mL.
在抑制菌丝生长方面,鱼腥草95%醇提物对豌豆根腐病菌、黄瓜枯萎病菌、马铃薯立枯丝核病菌和大白菜灰霉病菌均有良好的抑制作用,在最高处理浓度为0.002 g/mL时抑制率分别达到60.32%、58.50%、55.89%和55.17%;对辣椒白绢病菌几乎没有抑制作用,在最高处理浓度为0.002 g/mL时抑制率仅为17.19%;③在抑制孢子萌发方面,鱼腥草95%醇提物对大白菜灰霉病菌、马铃薯立枯丝核病菌、黄瓜枯萎病菌和豌豆根腐病菌抑制效果明显,在最高处理浓度为0.002 g/mL时的抑制率分别达到95.24%、90.48%、89.47%和85.71%,且在处理浓度不低于0.000 5 g/mL时对以上4种真菌孢子的抑制率超过40%;对辣椒白绢病菌抑制作用较弱,在最高处理浓度为0.002 g/mL时仅为43.48%。
-
Red cell membrane damnified by oxidation can be recovered with LSPC at 5.0 g/mL, the fluorescence polarization degree of the membrane was similar to normal level, indicate that increased anisotropic by membrane oxidation decreased with LSPC.2 Antioxidation Effect of LSPC on skinLSPC can improve body antioxidation ability by increasing the antioxidase synthesis and its activity in skin and serum.
半体内法测得LSPC能显著激活NK细胞活性。表明,LSPC对免疫功能有较强的调节作用。4莲房原花青素对酪氨酸酶及黑色素生物合成抑制作用初步研究 LsPC对黑色素的生物合成有显著的抑制作用。7.8 X10一49/L一5.09几LsPc对酪氨酸酶活力有抑制作用,其中,7.8 X1049/L一0.19/L时,随LsPC浓度增大抑制率下降;0.lg/L~4.og/L时,随着LSPC浓度增大抑制率逐渐增高,最大抑制率高达99.9%,且该抑制作用属于可逆的竞争性抑制。
-
The results showed that the activities of extracellular pectin methyltrans-eliminase, pectinase, extracellular C1 and proteinase were activated by asarum essential oils; the activities of pectin methylgalactuionase and intracellular C1 were activated at first, then inhibited and activated again; the activities of intracellular pectin methyltrans-eliminase were mostly inhibited; the activities of Cx were entirely inhibited by asarum essential oils, the percentage of inhibition was in proportion to the asarum essential oil concentration.
结果表明:辽细辛精油对胞外PMTE酶、果胶总酶、胞外C1酶和蛋白酶表现为激活作用,对PMG酶和胞内C1酶则表现为先激活后抑制再激活作用,对胞内PMTE酶主要表现为抑制作用;对Cx酶表现为完全的抑制作用,且酶活抑制率与精油浓度成正比。
- 推荐网络例句
-
I didn't watch TV last night, because it .
昨晚我没有看电视,因为电视机坏了。
-
Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.
今年以来,在北京的很多小区里,电梯液晶电视被撤了下来。
-
I'm running my simile to an extreme.
我比喻得过头了。