抑制作用的

Caesalpinia Sappan L. that had immunosuppressive function was investigated in this paper. On the basis of establishing the method of determining content of hydroxybenzene in Caesalpinia Sappan L., extractive technology was investigated by orthogonal design. Permeation, soxhlet and ultrasonic extraction were surveyed with water, thirty-five, sixty-five and ninety-five percent of ethanol as solvents.

本文以具有免疫抑制作用的中药苏木为研究对象，在建立苏木中总酚含量分光光度测定方法的基础上，以水、35%、65%、95%乙醇为溶剂，通过渗漉法、煎煮法、索氏法、超声波法对苏木的提取工艺进行了优选。

Results: Tyroserleutide can significantly increase the life span of H22 tumor-bearing mice by 50-70% in dosages of 20ug/kg/d-80ug/kg/d,specially the high dosage of 80ug/ml can significantly increase the life span by 69.24%; Tyroserleutide can inhibit the growth of transplanted hepatocellular tumor BEL-7402 in nude mice,the rate of tumor inhibition was25-50% in dosages of 40-320ug/ml ,the inhibition rate of 160ng/ml was 44.03%; Tyroserleutide could inhibit the growth of H22 and BEL-7402 tumor in a dose-dependent manner. Simultaneously, tumoricidal activity of tyroserleutide against BEL-7402 cell line in vitro was observed hinger when compared with the control group(P.05).The inhibition effect of 72hrs was higher than 24hrs,48hrs,96hrs.And specially the high dosage of 160ug/ml can significantly inhibit growth of tumor cell by 19.36%. Tyroserleutide can activated PEM and marked enhance cytotoxicity andphagocytosis functions in vitro and in vivo. The OD values of cytotoxicity were observed hinger when compared with the control group(P.05).The cytotoxicity of macrophages activated by tyroserleutide against BEL-7402 and B16-F10 was 35.58%,61.2% in vitro and21.39%,47.63% in vivo. The cytotoxicity rate of nude mice PEM was 32.86%,73.07% in vivo. Furthermore, tyroserleutide alone could stimulated the production of IL-1B TNF- a and NO by M . Tyroserleutide and LPS could synergistically activated M producing more cytotoxicity effectors. Conclusion: Tyroserleutide had inhibition functions against hepatoma carcinoma .Its possible mechanisms were related to the affect that Tyroserleutide could inhibit tumor cell directively and induce tumor cells apoptosis or death effectively.

结果：酪丝亮肽能显著延长腹水型肝癌H_(22)小鼠的生存时间，给药剂量为80μg／kg／d时疗效最显著，达到69.24％，在20μg／kg／d-80μg／kg／d剂量范围内生命延长率为50-70％，给药剂量与荷瘤鼠生存时间呈现一定量效关系；酪丝亮肽能显著抑制人肝癌BEL-7402移植瘤裸鼠的肿瘤生长，给药剂量为160μg／kg／d时疗效最显著，抑制率为44.03％，并且在40-320μg／kg／d剂量范围内抑制率为25-50％，给药剂量与肿瘤抑制率呈现一定量效关系；酪丝亮肽体外对人肝癌BEL-7402细胞生长有一定的抑制作用，在作用72hrs时各浓度酪丝亮肽对肿瘤细胞的抑制作用较24hrs、48hrs、96hrs明显，其中浓度为100μg／ml时抑制率达19.36％；酪丝亮肽体内外均能增强小鼠腹腔巨噬细胞对肿瘤细胞的杀伤：体外作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强，与效应细胞对照组相比有显著性差异(P＜0.05)杀伤率分别达到35.58％、61.2％；体内作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强，与生理盐水对照组相比有显著性差异(P 。05)，杀伤率分别达到21.39%、47.63%；裸鼠腹腔巨噬细胞经酪丝亮肤作用后对BEL一7402、B 16一F10杀伤功能明显增强，与生理盐水对照组相比有显著性差异(P.05)，最高杀伤率分别达到32.86%、73.07%；酪丝亮肤能增强单核巨噬细胞系统的吞噬功能，吞噬指数与生理盐水组比较有显著性差异(P.05)；酪丝亮肤体外作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO，与效应细胞对照组相比有显著性差异(P.05)；酪丝亮肤体内作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO，与生理盐水对照组相比有显著性差异(P.05)；酪丝亮肤能促进鼠巨噬细胞株R戌W264.7分泌合成IL一1p和NO，IL一1日、NO水平分别在酪丝亮肤作用24hrs、12hrs时达到高峰，酪丝亮肤单独应用能提高巨噬细胞的分泌合成功能，而且酪丝亮肤能与LPS协同作用刺激巨噬细胞的细胞毒效应分子分泌合成。

The release of CRH in stress response during menopause inhibited the secretion of GnRH, gonadotropic hormone and estrogen and induced the expression of intracellular HSP. As the growing of month, the expression of HSP70 and HSP70mRNA in uterus went up at the beginning and came down in the end. The result might be caused by the following:The increase of CRH and the decrease of estrogen during early menopause weakened the inhibitory effects on HSP.

本实验观察到随着大鼠月龄的增长子宫HSP70及mRNA的表达呈先增后降的变化，早期热休克蛋白的增加可能与CRH的增加及局部雌激素水平下降对HSP抑制作用的降低有关，但随着组织器官的衰退，其蛋白合成能力下降，因而表现出晚期热休克蛋白及基因表达下调。

These inhibiting social conventions tell us to choose an area of study in college that will produce the most financially rewarding career; they push us to climb the corporate ladder, to earn more money, to buy a bigger house, and to show our love and affection by giving "things;" and these social conventions have us misguiding our children down the same path.

这些起抑制作用的社会惯例总是要求我们去把自己的职业选定在学校里所学过的某个领域，认为这才能够使我们取得最大经济报酬；它们驱使我们去攀登企业和公司的楼体以赚取更多的钱；购买较大的住房，并拿出这些东西来表达我们对配偶的爱情和对子女的慈爱。

However, this approach conferred the resistance to not only myelopoietic cells but also tumor cells that have invaded or metastasized into bone marrow or circulating blood for nonspecific expression of the exogenous genes.

详细骨髓造血细胞中导入耐药耐辐射基因是克服放化疗对造血系统抑制作用的有效手段，但外源基因的非特异性表达也增加了残存在血液或者侵犯至骨髓中的肿瘤细胞耐受性。

GA, a inhibitor of HSP90, induces the expression of three hsp in nonstress condition.

对HSP90的结合蛋白质功能具有抑制作用的GA可增加三种hsp在正常生长条件下的基础表达水平。

The mRNA expression of PIBF in deciduas of early unexplained spontaneous abortion is lower than that of normal pregnancy, which shows the immunosuppressing effect of progesterone may be mediated by PIBF in pregnancy.

提示，在不明原因自然流产时，孕酮的免疫抑制作用的降低，可能是通过PIBF介导的。

The intestinal everted sacs study will be conducted to assess the relationship between the hydrophobicity of linear peptides and their Pgp inhibitory effect. Subsequently, drug interaction in pharmacokinetics will be evaluated using in vivo study in rats.

以小肠翻肠实验来探讨Linear peptide的脂溶性与P醣蛋白抑制作用的关系，进一步以老鼠体内试验来评估药动学上的变化。

We provide the architecture and learning algorithm of the quantizing net.

由于将信道传输特性直接引入到神经网络的构造中，因此，对网络进行训练后，最终得到对噪声信道影响具有一定程度的抑制作用的矢量量化器。

This preliminary case control study reconfirms that TWHf is a very potent herbal remedy to suppress mononuclear expressions of many inflammatory cytokines and pro-inflammatory molecules.

尽管只有少数的研究对象，本篇研究提供了在免疫致病机转上的可能证据来支持雷公藤对於僵直性脊椎炎患者周边血液单核球细胞内的许多发炎性细胞激素及其它和发炎反应有关的分子的基因表现具有强烈的抑制作用的说法。

I didn't watch TV last night, because it .

昨晚我没有看电视，因为电视机坏了。

Since this year, in a lot of villages of Beijing, TV of elevator liquid crystal was removed.

今年以来，在北京的很多小区里，电梯液晶电视被撤了下来。