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In this experiment,Xiaochaihu Oral Liquid was found to possess marked functions of inhibition on hydrops of rat articulatio talocruralis(p.05)induced by Carrageenin,of protection on acute liv- er function damage of rat,of depression of SGPT and LDH(p.01) and inhibition of the fever reaction of rabbit.

观察了小柴胡汤口服液的主要药理作用。研究表明,小柴胡汤口服液有显著抑制角叉菜胶诱发的大鼠踝关节水肿(p.05),保护四氯化碳所致的大鼠急性肝功能损害,有极显著降低血清SGPT及LDH的作用(P.01)。对家兔发热反应也有较好的抑制作用。

Results The ethanol extracts 0.48 gkg^(-1, macroporous resin eluate of aqua 0.3 gkg^(-1 and the further purification 0.1, 0.3 gkg^(-1 could hasten gastric emptying in mice. Furthermore, they restrained the inhibition of dopamine on gastric emptying in mice. They had no effect on the inhibition of atropine.

结果 醇提物0.48gkg^(-1、大孔树脂水洗脱物0.3gkg^(-1及继续纯化物01、0.3gkg^(-1对正常小鼠的胃排空有促进作用,并可拮抗多巴胺引起的小鼠胃排空的抑制作用,而对阿托品引起的小鼠胃排空抑制作用无影响。

To observe the antiviral activity of Algefacient and anti-inflammatory against influenza virus, cell culture technique was used in MDCK cells to get virus inhibitory rate and virus titer by MTT assay and hemagglitination test. Influenza virus infection model was established in mice, to observe the protection effect to mice death, the inhibitory effect to pulmonary index and pulmonary virus titer.

为评价清热消炎复方制剂的抗流感病毒活性,我们以病毒唑为对照,通过在体外观察病毒致细胞病变效应、MTT细胞染色检查病毒抑制率和检测病毒血凝滴度;在体内观察其对染毒小鼠的死亡保护作用,对小鼠流感病毒性肺炎的抑制作用,以及对小鼠肺内病毒增殖的影响,从而判定其抗流感病毒作用。

Nepalensis wall polysaccharide was prepared with hot water extraction,ethanol precipitation,dialyzation,and lyophilization.the crude polysaccharide was separated by deae-cellulose chromatography and purified by sephadex g-200 chromatography.the inhibit effect of the polysaccharide on lipid peroxidation of mice liver was conducted by tba method.the model of liver-injury induced by carbon tetrachloride(ccl4was used to validate the variety of the realated ast.results onefold ingredient polysaccharide was obtained after isolated and purified.conclusion the ingredient can remarkably inhibit lipid peroxidation of rat liver and significantly reduce activity of ast.

用热水提取,乙醇沉淀提取粗多糖,再经sevag法去除蛋白,透析去除小分子物质,冷冻干燥得楮头红多糖粗品;采用deae-52纤维素柱层析和sephadex g-200凝胶柱层析进行分离纯化;用tba法考察多糖的抗脂质过氧化作用;采用ccl4急性肝损伤模型,测定其血清中ast变化。结论获得一个楮头红多糖组分。tba法表明该组分对小鼠自发性脂质过氧化具有显著的抑制作用;在保肝试验中,给药组能明显抑制ast的升高,对肝损伤有一定的保护作用。

Metformin can inhibit the growth of lung adenocarcinoma cell lines significantly and potentiate cisplatin in a dose- and time-dependent manner in vitro. Cell-cycle progression is arrested in G1 stage and apoptosis is indued after metformin treatment.

二甲双胍可以使细胞周期循环阻滞于G1期,并诱导细胞的早期凋亡增加,从而有效抑制肺腺癌细胞株的体外增殖,其作用呈浓度及时间依赖性增强;二甲双胍与顺铂共同作用可以增强对肺腺癌细胞生长的抑制作用。

Antioxidative activity of flavonoids from Lespedeza bicolor were investigated by examining the scavenging effects on hydroxyl radicals and superoxide anion O2(superscript - and the inhibitions on auto-oxidation of lard, rape seed oil, and linoleic acid, The results showed that LBF had significant scavenging functions to free radical and superoxide anion, and the scavenging effect increased with the increase of the content of LBF; LEF can remarkably inhibit auto-oxidation of lard, rape seed oil, and linoleic acid, indicating its potential as a natural antioxidant.

通过二色胡枝子黄酮(Lespedeza bicolor flavonoids, LBF)清除羟自由基、超氧阴离子的效果及抑制猪油、菜油、和亚油酸的自氧化来研究二色胡枝子黄酮的抗氧化活性。其研究结果表明,二色胡枝子黄酮对清除自由基有显著性作用,且清除率随黄酮浓度的增加而增大;能够极显著地抑制猪油、菜油、亚油酸的自氧化(P.01),抑制作用随浓度的增大而增强。作为天然的抗氧化剂,二色胡枝子黄酮具有一定的开发利用价值。

The results showed that the three disparate treated substances have no visible antibacterial effect to E. coli , but a obvious effect to Staphylococcus aureus with inhibition of about 10 bacteriostasis units; have dissimilar effects to 10 kinds of fungi among the total kinds, and have a good inhibitory effect to Cytospora.coccodesHughes with fungistasis rate above 65%. After the gel filtration and activity detection, 50mM ammonium acetate was screened out as the more suitable eluents, the crudes were separated into strikingly unlike parts with obviously different antimicrobial activity.

结果表明,大蜡螟抗菌物质对大肠杆菌没有明显的抑制作用,而对金黄葡萄球菌抑制作用明显,抑菌活性单位在10左右;对10种植物病原真菌均有不同的抑菌活性,其中对苹果树皮腐烂病菌的抑制率达到65%以上;经过凝胶过滤分离,及对分离组分的抑菌活性测定,筛选出较合适的洗脱液为50mM乙酸铵,各分离组分抑菌活性差异明显,粗提物被分成了两个差异显著的部分。

In BP exposure experiment, except that the neutral red assay showed that BP significantly inhibited the haemocyte viability, the other methods did not detect the inhibition effect, besides, the results of the neutral red assay showed that the inhibition degree had a positive correlation with the concentration and exposure time of BP.

采用中性红比色法检测BP对栉孔扇贝血细胞活性具有显著抑制作用,且抑制程度与BP作用浓度、时间呈正相关,其余方法均未检测出BP对血细胞活性的影响。

Results showed that soil catalase activity was stimulated by the copper products and the inhibition of urease and sucrase activities by copper products were also observed,especially declined significantly in the treatment of BDM,the two enzymes activities in high ...

研究表明:铜制剂对土壤过氧化氢酶活性有刺激作用,而对脲酶、蔗糖酶活性均有显著抑制作用,尤以BDM对土壤酶活性的抑制率最强,高浓度处理下则未能检测出2种酶活性。

Result: With a high cancer-inhibiting rate on the animal model having been transplanted the cancer, this medicine can remarkably restrain the growth of cancer cells cultivated in vitro and improve the life quality of mouse model, and also shows obvious promotion and enhancement function on the DTH ear-swelling of mouse with cancer, the proliferation of mouse spleen lymphocyte induced by ConA and the cytokine (TNF-α、IFN-γ) of mouse with cancer respectively. It can obviously decrease the adverse effects like weight reduction, damage of viscera and degradation of life quality caused by the chemotherapeutic medicines, and has a remarkable stimulation on the lymphocyte proliferation induced by ConA. It is also able to improve the ratio of SMMC-7721 cells in G0-G1 period and reduce the cell amount in G2/M period to cut down the possibility of stepping into the division period; additionally, it can obviously inhibit some cancer genes of the cancer cells and meanwhile up regulate the cancer-inhibiting gene.

结果:本品能明显抑制体外培养肿瘤细胞的生长,对在体肿瘤移植模型动物具有较高的抑瘤率,能明显提高模型小鼠的生存质量;对荷瘤小鼠DTH耳肿胀、ConA诱导的小鼠脾淋巴细胞增殖、荷瘤小鼠细胞因子(TNF-α、IFN-γ)呈现明显的促进或提高作用;能显著减少化疗药所引起的小鼠体重降低、脏器损害以及生存质量下降等不良作用;本品含药血清对ConA诱导的淋巴细胞增殖具有明显的促进作用;能提高SMMC-7721细胞G0-G1期比例,降低G2/M期细胞数目,而减少其进入分裂期;对肿瘤细胞的多个癌基因具有明显的抑制作用,同时上调抑癌基因等。

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Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书,王祥生,李德昌。安徽省首次发现嗜群血蜱。

Chapter Three: Type classification of DE structure in Sino-Tibetan languages.

第三章汉藏语&的&字结构的类型划分。