抑制...

It is reported that alkannin and shikonin isolated from the roots of Lithospermum erthyrorhizon or Alkanna tinctoria and their acylshikonin derivatives are potent selective inhibitors of DNA Topoisomerase Ⅰ.

文献报导紫草素和酰基紫草素等具有DNA拓扑异构酶Ⅰ的选择性抑制活性。本组曾合成得到少量环异紫草素（8），它对小鼠白血病P-388肿瘤细胞具有强烈的抑制作用。

The cytotoxicity of these compounds were valuated by MTT and SRB methods using three cancer cell lines: HL-60, A-549, P-388. Cyclo-shikonin, and cyclo-alkannin have high cytotoxicity against HL-60.The chiral center of side chain has no effect on their activity. 2- 1-(Acetyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (105) has strong inhibition effect on P-388 cells. 2- 1-(isooctyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (108) and 2- 1-(2-furoyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (112) have high inhibition on A-549.Shikonin (1), alkannin (2), and their derivatives have the structural features of a planar chromophores and short side chain. We examined the ability to inhibit the telomerase.

抗肿瘤活性初步筛选测试采用小鼠白血病P-388肿瘤细胞和人肺癌A-549肿瘤细胞进行，结果表明侧链羟基的手性对抗肿瘤活性无明显影响；有数个化合物具有很好的体外抑制活性，特别是化合物2-（1-异辛酰氧基-4-甲基-3-戊烯基）-5，8-二羟基-1，4-萘醌（108）和2-[1-（2-呋喃甲酰氧基）-4-甲基-3-戊烯基]-5，8-二羟基-1，4-萘醌（112）体外显示对人肺癌A-549肿瘤细胞有强效；2-（1-乙酰氧基-4-甲基-3-戊烯基）-5，8-二羟基-1，4-萘醌（105）对小鼠白血病P-388肿瘤细胞有强效；环紫草素和环异紫草素对人白血病HL-60细胞有强烈抑制作用。

This may be through decreasing ALP activity, stimulating proliferation and inhibiting apoptosis of HVSMCs.

其作用可能与抑制ALP活性和促进细胞增殖、抑制凋亡有关。

On the other hand, the hepatic microsomal aminopyrine demethylase activity was obviously inhibited 2 hours after administration of the same dose of SY-801 and SY-640, while the content of hepatic cytochrome P-450 was not affected.

体外实验表明，SY-801和SY-640对正常小鼠、3-甲基胆蒽（3-MC）处理小鼠及苯巴比妥处理小鼠小鼠肝微粒体氨基比林脱甲基酶活性都具有明显的抑制作用，其中对3-MC处理小鼠肝微粒体氨基比林脱甲基酶活性抑制作用最显著。

It increased the content of chlorophyll, soluble protein, ammoniac nitrogen and soluble sugar in functional leaves, but declined the content of starch and nitrate nitrogen in functional leaves during the whole growth period of cotton.

研究表明，增加硝化抑制剂有利于棉花在生长发育的各个时期，功能叶片叶绿素、可溶蛋白、氨基态氮、可溶糖含量的积累，但抑制淀粉和硝态氮含量的积累。

A cultured experiment is conducted in laboratory to study the effect of weathered coal and boron on the ammonification and nitrification of urea and on phosphourus availability.

氮肥中脲酶抑制剂和硝化抑制剂的应用，是提高氮肥利用率比较成功的例子。

In this paper, the effects of enrofloxacin residues on soil ecological processes (soil respiration, soil cellulosic decomposition, soil ammonification , and soil nitrification) were studied.

1μg/ g土对土壤氨化作用有刺激作用，而较高浓度恩诺沙星残留(1μg/ g土，10μg/ g土)则会对其起抑制作用，药物作用活性期为 9d；不同浓度恩诺沙星对土壤硝化作用影响极其显著，当恩诺沙星浓度达到 1μg/ ml时，在 3～ 9d内，对土壤硝化作用有一定抑制作用。

The pH value in soil was significantly increased in litter aqueous extract of four decomposition stages. The NH+4-N concentration was significantly decreased in soil amended with litter aqueous extract of 10-day decomposition which promoted the growth of Aerobic azotobacter and Ammonifier but inhibited the growth of Aerobic cellulose-decomposer. Available phosphorus concentration was significantly increased and phenolic acid content was significantly decreased in soil amended with litter aqueous extract of 60-day decomposition which inhibited the growth of Aerobic azotobacter but promoted the growth of Aerobic cellulose-decomposer.

不同分解时间的凋落物浸提液均造成了土壤pH值的显著升高；分解10d的凋落物浸提液对土壤铵态氮的含量具有显著的降低作用，对土壤好气性自生固氮菌和氨化细菌的生长均具有显著的促进作用，而对好气性纤维素分解菌的生长具有抑制作用；分解60d的凋落物浸提液显著地降低了土壤酚酸含量，对土壤有效磷含量具有显著的升高作用，对好气性自生固氮菌的生长具有抑制作用，而对好气性纤维素分解菌的生长具有促进作用。

The inhibition effect of phytic acid as the inhibitor of α-amylase is also studied.

并对植酸作为α-淀粉酶抑制剂的抑制效果进行了研究。

Objective To investigate the inhibition of rapamycin in angiotensin Ⅱ-induced vascular endothelial cell proliferation.

目的 免疫抑制剂雷帕霉素对血管紧张素Ⅱ诱导的脐静脉内皮细胞抑制作用机制。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。